Dave Fernig @DaveFernig@qoto.org

Markus Sommer #biodata22 closing us out with "Structure‐guided isoform analysis for the human transcriptome".

Problem: We have many more transcript annotations than genes. Which isoforms actually represent functional proteins?

Leveraging folding algorithms (e.g. AlphaFold2) to score each isoform, high score = more likely to be functional. Showed some examples where this scoring approach matches experimental data. Says not perfect, but helpful data point.

Website: https://www.isoform.io/

Trippa alla Romana Fritta (Fried Roman Tripe) Recipe https://www.vice.com/en_us/article/5dgkak/trippa-alla-romana-fritta-fried-roman-tripe-recipe #Vice #RSS #News #Bot #tomatosauce #semolina #Pecorino #Italian #dinner #Recipe #offal #Tripe #fried #lunch #organ

It's just not cricket.
#Tripe

OTD in 1940 Soviet Foreign Minister Molotov arrived in Berlin, received Guard of Honor and had friendly meet with Hitler.

Totally not allies

We do not need a strong economy to pay for the NHS. We need a strong NHS as a pre-condition of a strong economy. Government spending always comes before tax revenues can flow in. Never more true than the moment we are in now.

So I'll start as I'd like to think I'll go on - with a photo! And I'll start with a good one! It's not new, but hey, you've probably not seen it before 😂

#Peebles in the Scottish Borders at sunset, a January a few years ago

It was spectacular! And pure luck that the photo wasn't ruined by camera shake as I was shooting over a 6 foot wall!

@StephenSenn The defender of GenStat and the destroyer of the Number Needed to Vaccinate numpties is here.
@lakens @Andi @AndrewPGrieve @mike_johansen

First tentative foray into Mastodon. Hello hello is anyone there?

The sky here is always up to wonderful things...

The year is 2050. Food production has collapsed. Soylent is now the only food available.

In an attempt to increase sales, the major Australian supermarkets bring a new product to market.

Introducing "Vegemite Soylent"

Loch Lomond, still as glass on a gentle October morning

#Mastodon #Fediverse #choice

Which One

Any way we can persuade Elon Musk to buy The Sun, The Daily Mail and the Daily Express?

Mastodonians, join me here and make me the most followed politician on the planet!

https://t.me/liveukraine_eng/804 ⚡️🇺🇦 President Zelensky: Today is a historic day. We are regaining Kherson. As of now, our defenders are approaching the city. But special units are already in the city. The people of Kherson were waiting. They never gave up on Ukraine. Hope for Ukraine is always justified – and Ukraine always regains its own. And even when the city is not yet completely (VIDEO and more) #Ukraine #News #War #Russia

The spike from the recent innflux of twitter users is so enourmous it has completely distorted the users graph. You cant evenn read the numbers any more and the daily user graph spiked past the total user graph.

Wow.. ok then.

It really is time that the government got serious about fraud https://www.taxresearch.org.uk/Blog/2022/11/11/it-really-is-time-that-the-government-got-serious-about-fraud/ The government only detects 1% of fraud committed against it. The loss might exceed £50bn a year, with the tax gap on top of that. If they want to find savings this is where to look.

Freddy demonstrates being a “Good Boy” holding perfectly still for a long exposure nighttime photo…. For such a tear away I was pretty impressed!