Fly_arama @Fly_arama@qoto.org

📢New on the Node: Uncovering non-canonical functions of the Hippo pathway

Check out the #behindthepaper story by Heya Zhao revealing the role of Hippo pathway in cell fate decisions of the #drosophila eye:

https://thenode.biologists.com/behind-the-paper-story-uncovering-non-canonical-functions-of-the-hippo-pathway-%ef%bf%bc/research/

#devbio

Brilliant new paper by Naomi #Oreskes, concluding that "our overall situation suggests that it does not suffice for scientists simply to supply #factual #information, and leave it at that. Scientists need as well to engage actively with the recipients of that information." https://link.springer.com/article/10.1007/s43538-022-00121-1

We're excited to announce a new scheme aimed at supporting postdocs as they go on the job market. Our 'Pathway to Independence' programme will provide mentorship, support and networking opportunities to a group of researchers transitioning to independence.

https://journals.biologists.com/dev/article/149/23/dev201456/285866/

#devbio #devbiol

PSA: #FlyBase just came out with an update where nomenclature for genes with ambiguous names (e.g. dl vs. Dl) was changed to avoid confusion. So Dl is now "Delta", while dorsal remains "dl". I suspect it may take some time for the field to absorb these changes.
See more examples in the news release:
https://tinyletter.com/FlyBase/letters/flybase-fb2022-06-released
#Drosophila

Neuro-evo conference at HHMI Janelia on May 15-18, 2023. Join us for the 3rd edition!

Application deadline: Jan 27 (11:59 p.m. EST) 2023.

Apply here: https://www.janelia.org/you-janelia/conferences/neuro-evo-a-comparative-approach-to-cracking-circuit-function-iii

"The third instalment of this meeting will once again bring together neuroscientists working on a broad diversity of animal models in an effort to compare circuits across phyla as a means to crack their function."

#NeuroEvo #Janelia #HHMI #conference #science #academia #neuroscience #DevBio #connectomics #connectome

Do you want to go to the Evolution meeting in 2023? Do you live outside of a high GDP country? Check out @eseb 's conference travel award! https://eseb.org/prizes-funding/conference-travel-award/

#PhDposition studying #adaptation in European #Drosophila melanogaster populations. You will integrate #population #genomics data with genome wide expression & #chromatin accessibility data to unravel mechanisms underlying #natural #variation in quantitative phenotypic traits.

Referenced link: https://www.nature.com/articles/d41586-022-04147-9
Discuss on https://discu.eu/q/https://www.nature.com/articles/d41586-022-04147-9

Originally posted by Nature Portfolio / @NaturePortfolio@twitter.com: https://twitter.com/NaturePortfolio/status/1599127581038714888#m

“Be respectful, and take your roles in organizing these sessions seriously,” writes @gwendoesscience in @Nature. “Publicly reliving our trauma to satisfy your (equity, diversity and inclusion) obligations is not our job.” https://www.nature.com/articles/d41586-022-04147-9

To obtain enough live cells from #Drosophila melanogaster eye-antennal imaginal discs for 10X #scRNAseq, we combined mechanical and chemical dissociation. scRNAseq showed that the protocol captured most relevant cell types. 2/8

📰 "Genetic architecture of natural variation of cardiac performance from flies to humans"
by 🔬 Saswati Saha, Lionel Spinelli, Jaime A Castro Mondragon, Anaïs Kervadec, Michaela Lynott, Laurent Kremmer, Laurence Roder, Sallouha Krifa, Magali Torres, Christine Brun, Georg Vogler, Rolf Bodmer, Alexandre R Colas, Karen Ocorr, Laurent Perrin
https://pubmed.ncbi.nlm.nih.gov/36383075/ #Drosophila

A great new resource from #FlyBase - a wiki page for newcomers into the #Drosophila field:
https://wiki.flybase.org/wiki/FlyBase:New_to_Flies

Do animals have consciousness? Documentary in French or German on how animals may have evolved a sense of self, with some fruit fly #drosophila experiments as well:

https://buff.ly/3HbHaT1

3,013 neurons, half a million synapses: the complete #connectome of the whole #Drosophila larval brain!

Winding, Pedigo et al. 2022. "The connectome of an insect brain" https://www.biorxiv.org/content/10.1101/2022.11.28.516756v1

We’ve mapped and analysed its circuit architecture, from sensory neurons to brain output neurons, as reconstructed from volume electron microscopy, and here is what we found. 1/

#neuroscience #connectomics #vEM #volumeEM

🗓️ Save the date! Next Friday 2nd December at 11am UTC, we'll be hosting a free online panel discussion examining the outcomes of #COP27. We have an exciting line-up of speakers! Registration link to follow soon.

We have an exceptional opportunity at our center for a new group leader at VIB in Leuven. We are looking for a new colleague who wants to use computational methods to investigate molecular and/or cellular aspects of neurobiology. This position not only comes with substantial and renewable core funding and start-up package, but it is also linked to a tenure track position at KU Leuven.

More information on our center can be found on our website https://cbd.sites.vib.be/en.

“The disproportionate scientific productivity of elite researchers can be largely explained by their substantial labor advantage rather than inherent differences in talent.” #AcademicMastodon #ScienceMastodon https://www.science.org/doi/10.1126/sciadv.abq7056

#drosophila genome, 1921 (From Bridges DOI:10.1073/PNAS.7.4.127)

#CRISPRpapers #CRISPR

New cytosine base editors!

https://www.nature.com/articles/s41587-022-01532-7
https://www.nature.com/articles/s41587-022-01533-6
(Another by Nicole Gaudelli's team apparently coming soon.)

Why care:
Base editors can install predictable gene edits without DNA breaks. The described C-to-T editors are as efficient at current tools, but create less off-target damage in the genome and are smaller, which helps with delivery in vivo.