Antigen-presenting #Pericyte #MultipleSclerosis
PDGFRβ+ Pericyte MHCII KO->
In vitro
⏬CD4+ T cell proliferation & activation
In🐭adoptive transfer EAE
⏫CD3+ T cell entry
No change in BBB, CD4+ T cell, Mɸ, cytokine
Dr. Luisa Klotz lab @IJMS_MDPI 2022
https://www.mdpi.com/1422-0067/23/21/13081/htm
#introduction Hi everyone, I am a developmental biologist, working at the IBDM (Developmental Biology Institute of Marseille) (CNRS and Aix Marseille University). I study muscle development and regeneration, trying to decipher the dysfunctional mechanisms underlying muscle pathologies. I would post with any new equivalent of the very useful #MyoTwitter
Landmark re-read😋
#EndothelialCell #ClonalExpansion in the development of #CerebralCavernousMalformations
"Cavernomas are composed of clones of Ccm3−/− cells that attract Ccm3+/+ cells"
Dr. Matteo Malinverno & Elisabetta Dejana lab Nature Comms 2019
https://www.nature.com/articles/s41467-019-10707-x
Let’s start a thread with all our: #DevBio #DevBiol #science peeps. Please add more below to help us find everybody! Who are your DevBio friends? We need to post to make this place more vibrant:
@DenisDuboule
@opourquie
@mads100tist
@RogersLabUCD
@HaoYin
@scottbarolo
@kkroll
@SpagnoliLab
@Mill_lab
@jamesbriscoe
@MokalledLab
@AaronJohnson
@ebardot
@ondinecleaver2022 @DenisDuboule @opourquie @mads100tist @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot
Most excellent community wrangling Ondine! Little trick to filter is to make a #DevBio list- it is a little cumbersome as everyone and their instance needs to be individually searched and added, but then if you click on your list- posts only from those DB 'Mamoots' will appear. It can help focus from the other noise.
@ondinecleaver2022 @DenisDuboule @opourquie @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @Mill_lab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot Ondine, we could pull the followers and followed by the Twitter SDB account and have it as a CSV file people can use to merge their follows. What do you think?
Isolation of Popliteal Lymphatic Vessels from mouse hindlimb & primarily culture >10k lymphatic mural/muscle cells out of one single vessel🤠
Inject some Evans blue to visualize PLVs
Dr. Guillermo Arroyo-Ataz & Dennis Jones STAR Protocols 2022
https://www.sciencedirect.com/science/article/pii/S2666166722006803
Surgery or Endovascular Therapy for #ChronicLimbThreateningIschemia
A good-quality great saphenous vein for conduit+
Surgery-first->
32%⏬risk of MALE/Death vs endovascular strategy
Dr. Alik Farber, Matthew Menard, et al BEST_CLI NEJM 2022
https://www.nejm.org/doi/10.1056/NEJMoa2207899
#EndothelialCell Mst1 KO->
⏫EC inflammation by #OscillatoryShearStress 0.5±4 dyn/cm2 1 Hz
⏫🐭#Atherosclerosis
Independent of #YAP (?TAZ🧐)
Mst1 phosphorylates #Connexin43->⏬Hemichannel activity, not gap junction coupling
Dr. Ding Ai lab Circ Res 2022
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.122.321322
RT @TonyZador@twitter.com
We used BARseq in situ sequencing to identify genes in ***1.2 million neurons*** throughout the mouse brain
We found that cortical areas with similar cell types are also interconnected. We call this “wire-by-similarity.”
https://www.biorxiv.org/content/10.1101/2022.11.06.515380v1
1/n
🐦🔗: https://twitter.com/TonyZador/status/1589804833665560577
Watch this and try not to think about the space.
Congratulations @DInoueMT 💪🏼
---
RT @DInoueMT
After reading the paper, you will get some idea to understand why two different types of chiral patterns, i.e. monopolar rotational spiral and bipolar nematic pattern, emerge from gliding microtubules.
https://twitter.com/DInoueMT/status/1589590934840573952
A few tips for newcomers, as I have learned myself in the past week...
#AltText Descriptions: Please use them, many folks here depend upon them and have been using them for years before we all arrived.
#CamelCase: when you use hashtags, use Camel Case if you have more than one word: #WelcomeToMastodon is easier to read than #welcometomastodon - so do that. Use WAAAAY more hashtags than you are used to on Twitter. Mastodon is hashtag dependent.
#ContentWarning: If you are posting something that might even in the slightest trigger another person, use the Content Warning (CW) option that you can toggle on at the bottom of the toot window. It's polite here. People can choose how they want to view and interact. Use CW more than you are used to on Twitter.
#Diversity: a few people have commented, "lots of white men here!" Well, ok, but you can also find each other by using hashtags like #WomenInStem #BlackMastodon and many more including my favorites that I started up: #Desi and #MixedDesi (i.e. me). Start your own if you don't see yourself represented, so others can find you, too.
#DMs: are under the globe option in the toot window for privacy setting and they appear in your full list / feed of notifications (don't freak out at that).
#Donations: This is all run by volunteers. Make a donation. Click on the "about this server" at the bottom of your screen (might appear in a different location than on mine) and find out who is running your server and how to make a donation. And thank them!
#Introductions: Please write a friendly intro and use the hashtag #introduction so people can learn about you. Be interested in others. Grow your community through daily, friendly interaction.
Have fun! This is like a big global cafe with many tables to sit at, and conversations to be had.
Lots more tips linked in my feed. Welcome!
Hey everyone !
Time for my #science #introduction
I am the PI of the @cellcommlab @ the UKE in Hamburg, Germany. We use #microscopy & #imageanalysis to study how cells move & communicate.
I am from #Chile, where I did my #PhD at PUC, then moved to Paris to work at the Institut Curie and IPGG.
After quite some years in #science (20 since I started my BSc !) I keep my fascination to observe how cells do things, like these migrating leukocytes.
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op