Issue 21 is complete!
On the cover is a 3D surface rendering of a lung lobe from a mouse #embryo, showing the relationship between the arterial network (red) and the lung epithelium (grey) from Chandrasekaran et al.
Also in Issue 21:
- 8 #Research Highlights
- In #preprints article on reconstituting the ovary
- Ruth Bellairs obituary
- 2 author interviews
- Poster & article on resolving #morphogenesis into quantifiable cell behaviours
- Nuclear movement Review
Meet the #preLighters: Chee Kiang (Ethan) Ewe. 🌟
https://prelights.biologists.com/news/meet-the-prelighters-a-virtual-chat-with-chee-kiang-ethan-ewe/
Ethan is a #postdoc in the lab of @Odedrechavi at Tel Aviv University, Israel, where he studies the molecular basis of epigenetic #inheritance.
We spoke about his very international #career, the #mentors along the way, his future #goals, and the importance of #preprints both to him and the biological #community.
Ooh another really interesting paper on #alzheimers and #lactadherin
Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease
Phospholipase Cε #Aortopathy
Plce1 KO🐭 are susceptible to ANGII-induced ascending #AorticAneurysm+Dissection
Role of adventitial myofibroblast cytokines?😎
Dr. Alan Smrcka, Santhi Ganesh, Markus Bitzer labs AJP Heart Circ 2022
https://journals.physiology.org/doi/abs/10.1152/ajpheart.00262.2022
A new #SpatialTranscriptomics technique was published on Cell! The authors used polony gels to capture the RNA in situ, and used pixel-seq to map #singlecell transcriptomes back to the tissue. Amazing experimental design! https://www.cell.com/cell/fulltext/S0092-8674(22)01367-8
BulkSignalR, a R package to infer ligand-receptor networks from bulk data including Visium #rstat #RNAseq #SpatialTranscriptomics
https://www.biorxiv.org/content/10.1101/2022.11.17.516911v1
scFates: a python package for pseudotime analysis from single cell data #scRNAseq #scATACseq #bioinformatics #python
https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btac746/6832042
Kidney epithelial #Tubuloid
CD24+ epithelial progenitor-derived
4-phase protocol, Matrigel +Wnt3a/RSPO1, grow > 6 mo
CRISPR modeling #ADPKD, Cyst size responsive to #Tolvaptan
Super-impressive single-cell or single-nuclei RNAseq analyses to dissect the spatiotemporal molecular/cellular dynamics of this cool renal tubuloid, laying a critical foundation to enhance its clinical utilities👍
Wonderful #Lumenogenesis of CD24+ epithelial progenitor-derived nephrospheres, day 7 in Matrigel🤠
Dr. Rafael Kramann lab @NatureGenet 2022 @jackxuyx @KuppeChristoph @rkramann
https://www.nature.com/articles/s41588-022-01202-z
Welcome @karinayaniv ! I’m also just testing the waters here. I like it :) Slowly but surely finding all ours friends and colleagues! #science
@Natashaobrown
Really happy that you like it😆
Editing a gateway for #CellTherapy across #BloodBrainBarrier
An excellent review🤠 Learn a lot!
Lesson from Leukocyte-#BBB interaction->
Engineering strategies->
⏫Cell delivery to injured🧠#Stroke
Dr. Rust Ruslan lab Brain 2022
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac393/6832391
#EndothelialCell MEK1 #VascularMalformation
P1 topical 4OHT-induced mosaic EC MEK1 K57N transgene (what is the efficiency🧐)->
50% death by P30 +multiorgan VM (Arteriovenous malformation or other lesions) & Hemorrhage
Lesions composed of both mutant & WT EC
Dr. Patrick Smits lab Angiogenesis 2022
https://link.springer.com/article/10.1007/s10456-022-09853-6
The latest from the lab spearheaded by @vijaykrishnarag: Cell derived matrices from bovine corneal endothelial cells as a model to study cellular dysfunction. #ophthalmology #cornea @nationaleyeinstitute https://www.sciencedirect.com/science/article/abs/pii/S0014483522003840?via%3Dihub
Hi everyone👋 #preLights is a #preprint highlights service run by the biological #community and supported by #Co_Biologists allowing researchers to:
🔎 Sift through the growing volume of preprints.
💡 Highlight new thinking or new techniques across the biological sciences.
📝 Comment on preprints that are of particular interest.
👥 See comments and opinions of other researchers.
Toots from Reinier Prosée, the preLights community manager.
12q, an optimized small chemical activator of #Sirt6
Comprehensive analyses vs MDL-800->
⏫Sirt6 deacetylase & demyristoylase activities
⏫Anti-#PancreaticDuctalAdenoCarcinoma activity
Look forward to more studies on its Non-tumoral benefits?🧐
Dr. Shengyong Yang lab J Med Chem 2022
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.0c01183
After scoping out Mastodon for about a week now, it's probably time for an #introduction
Hi I'm Alex, a Reviews #Editor for @Dev_journal, a community #journal covering #devbio, #stemcells & #regeneration. Development hosts the #devbiol community blog @the_node and is published by the @Co_Biologists.
I'll mostly be tooting about amazing #devbio research and conferences, and occasionally about personal stuff like #books, #reading, #gardening and other adventures on my bike or #kayak.
Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.
We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.
Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown
Pancreatic Rab11a/Rab11b dKO->
Aberrant polarized transport of apical/basolateral proteins->
AMIS supernumerary->
Defects in ductal #Lumenogenesis; Acinar morphogenesis; Pancreatic cell lineage dysregulation
Highly intriguing, PancRab11KO->⏬Sox9+ bipotent progenitor & #Islet mass-> #GlucoseIntolerance in suvived adult🐭
Lumenized epithelial paracrine or endocrine-autonomous defect?😆
No baseline change in fast glucose. Insulin/glucagon? Adult islet histology-Amyloid degeneration?
The branched, lumenized pancreatic duct is fragmented into disconnected Microlumens + enlarged Cyst in PancRab11KO🐭
Can't help but think Rab35 in anisotropic Lumenogenesis of liver #BileCanaliculi
Is there a primary hydro-osmotic defect here?😋
Still, what happens to pancreatic vascular morphogenesis in Panc-Rab11 KO🐭?(Surely, epithelia & endothelia are coupled🤪)
More importantly, now it's the magic timing if you also want to have such amazing stories
Cleaver lab is recruiting TWO postdocs
Dr. Ondine Cleaver lab @ondinecleaver2022 bioXRiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.17.516976v1
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op