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Issue 21 is complete!

On the cover is a 3D surface rendering of a lung lobe from a mouse #embryo, showing the relationship between the arterial network (red) and the lung epithelium (grey) from Chandrasekaran et al.

Also in Issue 21:
- 8 #Research Highlights
- In #preprints article on reconstituting the ovary
- Ruth Bellairs obituary
- 2 author interviews
- Poster & article on resolving #morphogenesis into quantifiable cell behaviours
- Nuclear movement Review

journals.biologists.com/dev/is

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Meet the #preLighters: Chee Kiang (Ethan) Ewe. 🌟

prelights.biologists.com/news/

Ethan is a #postdoc in the lab of @Odedrechavi at Tel Aviv University, Israel, where he studies the molecular basis of epigenetic #inheritance.

We spoke about his very international #career, the #mentors along the way, his future #goals, and the importance of #preprints both to him and the biological #community.

#Introduction #Interview #ECRs

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Ooh another really interesting paper on #alzheimers and #lactadherin

Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease

nature.com/articles/s41586-022

Phospholipase Cε

Plce1 KO🐭 are susceptible to ANGII-induced ascending +Dissection

Role of adventitial myofibroblast cytokines?😎

Dr. Alan Smrcka, Santhi Ganesh, Markus Bitzer labs AJP Heart Circ 2022
journals.physiology.org/doi/ab

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A new #SpatialTranscriptomics technique was published on Cell! The authors used polony gels to capture the RNA in situ, and used pixel-seq to map #singlecell transcriptomes back to the tissue. Amazing experimental design! cell.com/cell/fulltext/S0092-8

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Kidney epithelial

CD24+ epithelial progenitor-derived
4-phase protocol, Matrigel +Wnt3a/RSPO1, grow > 6 mo
CRISPR modeling , Cyst size responsive to

Super-impressive single-cell or single-nuclei RNAseq analyses to dissect the spatiotemporal molecular/cellular dynamics of this cool renal tubuloid, laying a critical foundation to enhance its clinical utilities👍

Wonderful of CD24+ epithelial progenitor-derived nephrospheres, day 7 in Matrigel🤠

Dr. Rafael Kramann lab @NatureGenet 2022 @jackxuyx @KuppeChristoph @rkramann
nature.com/articles/s41588-022

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Welcome @karinayaniv ! I’m also just testing the waters here. I like it :) Slowly but surely finding all ours friends and colleagues! #science

Editing a gateway for across

An excellent review🤠 Learn a lot!

Lesson from Leukocyte- interaction->
Engineering strategies->
⏫Cell delivery to injured🧠

Dr. Rust Ruslan lab Brain 2022
academic.oup.com/brain/advance

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MEK1

P1 topical 4OHT-induced mosaic EC MEK1 K57N transgene (what is the efficiency🧐)->
50% death by P30 +multiorgan VM (Arteriovenous malformation or other lesions) & Hemorrhage

Lesions composed of both mutant & WT EC

Dr. Patrick Smits lab Angiogenesis 2022
link.springer.com/article/10.1

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The latest from the lab spearheaded by @vijaykrishnarag: Cell derived matrices from bovine corneal endothelial cells as a model to study cellular dysfunction. @nationaleyeinstitute sciencedirect.com/science/arti

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Hi everyone👋 #preLights is a #preprint highlights service run by the biological #community and supported by #Co_Biologists allowing researchers to:

🔎 Sift through the growing volume of preprints.
💡 Highlight new thinking or new techniques across the biological sciences.
📝 Comment on preprints that are of particular interest.
👥 See comments and opinions of other researchers.

Toots from Reinier Prosée, the preLights community manager.

#Introduction #Biology #ECRs #Science #AcademicMastodon

12q, an optimized small chemical activator of
Comprehensive analyses vs MDL-800->
⏫Sirt6 deacetylase & demyristoylase activities
⏫Anti- activity

Look forward to more studies on its Non-tumoral benefits?🧐

Dr. Shengyong Yang lab J Med Chem 2022
pubs.acs.org/doi/full/10.1021/

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After scoping out Mastodon for about a week now, it's probably time for an #introduction

Hi I'm Alex, a Reviews #Editor for @Dev_journal, a community #journal covering #devbio, #stemcells & #regeneration. Development hosts the #devbiol community blog @the_node and is published by the @Co_Biologists.

I'll mostly be tooting about amazing #devbio research and conferences, and occasionally about personal stuff like #books, #reading, #gardening and other adventures on my bike or #kayak.

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#Introduction

Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.

We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.

Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown

Pancreatic Rab11a/Rab11b dKO->
Aberrant polarized transport of apical/basolateral proteins->
AMIS supernumerary->
Defects in ductal ; Acinar morphogenesis; Pancreatic cell lineage dysregulation

Highly intriguing, PancRab11KO->⏬Sox9+ bipotent progenitor & mass-> in suvived adult🐭

Lumenized epithelial paracrine or endocrine-autonomous defect?😆

No baseline change in fast glucose. Insulin/glucagon? Adult islet histology-Amyloid degeneration?

The branched, lumenized pancreatic duct is fragmented into disconnected Microlumens + enlarged Cyst in PancRab11KO🐭

Can't help but think Rab35 in anisotropic Lumenogenesis of liver

Is there a primary hydro-osmotic defect here?😋

Still, what happens to pancreatic vascular morphogenesis in Panc-Rab11 KO🐭?(Surely, epithelia & endothelia are coupled🤪)

More importantly, now it's the magic timing if you also want to have such amazing stories

Cleaver lab is recruiting TWO postdocs

Dr. Ondine Cleaver lab @ondinecleaver2022 bioXRiv 2022
biorxiv.org/content/10.1101/20

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Does anybody else find Mastodon to be buggy (slow)? I’m sure it’s the crush of people fleeing the bird site. But wondering if it’s just me.

(Also I realize the servers are maintained by volunteers and not a for-profit company, hence grateful, but curious).

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