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Hao Yin boosted
Ondine Cleaver

Excited to share our preprint on the role of Rab11 in microlumen formation during early pancreas development.

When Rab11 is genetically deleted in pancreatic epithelium:
-intracellular cargo containing apically targeted proteins are stuck in the cell
-Lumens fail
-Branch morphogenesis is defective
-Beta cell mass is reduced

Cool work spearheaded by grad student Haley Barlow. #DevBio #DevBiol #Pancreas #BetaCell #Lumen #SendFeedback

biorxiv.org/content/10.1101/20

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Hao Yin boosted
Aging Highlights

The small RNA landscape is stable with age in Drosophila

#smallRNA #Drosophila #aging

journals.plos.org/plosone/arti

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Hao Yin boosted
Barbara Juarez, Ph.D

🚨JOB ALERT🚨
My lab at University of Maryland-Baltimore is hiring a postdoc!

Consider applying if you are interested in cellular regulators of excitability #ionchannels, mouse brains🧠, CRISPR-Cas9 gene-editing 🧬✂️, and behaviors 🐭
(more info here: thejuarezlab.com)!

We are dedicated to the promotion of diversity and inclusivity in science.

We can also connect at #ACNP2022 in December!

#neuroscience #neurojobs #PDjob #URMinSTEM #BlackinNeuro #DSPAN #HHMIGilliam #NeuroMastodon

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Hao Yin boosted
DaveFinlayTCD

RT @LyssiotisLab
Hyping new @SciImmunology from @_Hanna_Hong (before burns down 🔥)

➡️OXPHOS Promotes Apoptotic Resistance and Cellular Persistence in TH17 cells in the Periphery and Tumor Microenvironment ⬅️

Read on for a
science.org/doi/10.1126/sciimm

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Hao Yin boosted
SpagnoliLab

New insights on pancreatic morphogenesis from @ondinecleaver@ lab!

Another link between #morphogenesis and #differentiation!

Pre-print 🔗
qoto.org/@biorxivpreprint/1093

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Hao Yin boosted
bioRxiv

Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. biorxiv.org/content/10.1101/20

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Hao Yin boosted
TrangAston :verified:

#cardiology #CardioTooter Future in medicine : Inflammosomes .Targeting the Inflammasome in Cardiovascular Disease
jacc.org/doi/full/10.1016/j.ja

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Hao Yin

Airway Inflammation

SMMHC-driven α7 transgene in ovalbumin♀️🐭->
⏬Airway leukocyte infiltration
⏬Pulmonary resistance (not compliance)
Re-balanced cytokine/chemokine production

Dr. Mariam Ba lab FASEB Bioadv 2022
faseb.onlinelibrary.wiley.com/

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Hao Yin

Some encode functional peptides😎

LncPSR & its protein, Arteridin, complex with Ybx1->
⏬ contractile phenotype

AAV2-SM22α-shPSR⏬ANGII-induced SMC hypertrophy in🐭aorta

Dr. Y Wang, G Wu, C Zeng labs @CircRes 2022
ahajournals.org/doi/10.1161/CI

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Hao Yin

@sengerf

No idea yet. If I try it on skeletal muscle in the incoming month, I will update

1
Hao Yin

😎

50% tetrahydrofuran in ddH2O to clear🐭🧠etc ≤ 48 h
80% Nycodenz+7M urea-> RI 1.518
Post-clearing cryosectionable, whole-mount immunofluorescence
Minimal volume change

Dr Chih-Wei Hsu & Joshua Wythe labs eLife 2022 @CWLoganHsu @wythelab
elifesciences.org/articles/774

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Hao Yin

Landmark👹

How fetal liver vasculature serves as a transient niche for expansion while undergoing

Fetal liver hematopoietic stem cell niches associate with portal vessels

Dr. Paul Frenette lab Science 2015
science.org/doi/10.1126/scienc

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Hao Yin boosted
TrangAston :verified:

#neuroscience Anatomy of Sleep @nature
ninds.nih.gov/health-informati

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Hao Yin boosted
Kristin Knouse

Thrilled to share our lab's first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal.

cell.com/cell-genomics/fulltex

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Hao Yin


Next-gen

activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells->
⏬adverse phenotypes in🐭+

Dr. Yoshikazu Johmura & Makoto Nakanishi labs Nature 2022
nature.com/articles/s41586-022

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Hao Yin boosted
ergyrase

@ondinecleaver2022 @DenisDuboule @opourquie @mads100tist @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @Mill_lab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot @MarieKmita

Few additions if not overlapping:
@DavidBrueckner (who actually helped many of us to join mastodon!)
@edouardhannezo
@MikiEbisuya
And @knoepfler is here, and was looking for exactly this kind of thread the other day

1
Hao Yin

~50% Olig2+ Progenitors migrate along blood vessel in prenatal🧠cortex🤠

Vessel-guided migration favors superficial cortex as Astrocyte destination

CXCL12-> AP CXCR4/7

Dr. Hidenori Tabata & Kazunori Nakajima labs Nat Comm 2022
nature.com/articles/s41467-022

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Hao Yin

Pulmonary

Hypoxia
6 dyn/cm2
Patient ECFC+HPASMC co-culture

BMPR2-Sox17->
Prostacyclin production->
⏬ proliferation

Comparative transcriptomics vs PAH gene sets

Dr. Beata Wojciak-Stothard lab Communications Biology 2022
nature.com/articles/s42003-022

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Hao Yin boosted
Francoise Helmbacher

Thank you @ondinecleaver2022 for the initiative

a few more:

@HaoYin @guijacquemet
@dgaboriau
@pj_saez
@rburdine
@juanonyme
@a_tsakiridis @maxvcg @harryleitch @AxelVisel @MHVerlhac @juliettemathieu @t_rayon @bbruneau @Etche_homo @albertcardona
@Amayran
@generegulation
@Sophie_Chauvet @kkroll @Mill_lab @MarieKmita

Everyone who wants to be known by the community should make a post with #DevBio or #DevBiol hashtags.
These will be seen across servers, making it easier to find each other

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Hao Yin boosted
Ondine Cleaver

35.5 mile bike today 🚴‍♀️🚴🚴‍♂️Not bad!

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