Hao Yin @HaoYin@qoto.org
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
#Pericyte internalizes-cleaves-degrades α-Synuclein aggregates, even in co-culture with "professional" Microglia😎 (relative efficiency?🧐)
How α-Syn fibril uptake impact pericyte metabolism & functions?
#ParkinsonsDisease
Dr. Birger Victor Dieriks & Mike Dragunow labs @PLOSONE 2022
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0277658
$150! 
Is there a waiver one can apply for 
#Microglia jointly degrade fibrillar α-Synuclein cargo by distribution through #TunnelingNanoTube
#TunnelingNanoTube-mediated social behaviors of Microglia
Microglia take α-Synuclein from & send Mitochondria to overloaded neighbors
Dr, Michael Heneka lab @cellcellpress@twtr.plus2021
https://www.cell.com/cell/fulltext/S0092-8674(21)01054-0
Hao Yin
boosted
For clinicians or scientists interested in the clinical management of aortic diseases, join us tomorrow for a live virtual CME course: https://advances.massgeneral.org/cardiovascular/event.aspx?id=1070
Hao Yin
boosted
In preprints: humans, the new model organism
James Wells and Ziyuan Guo highlight three preprints that use hPSC-derived tissue to dissect human development and disease.
Get in touch if you would like to write an ‘In preprints’ article for @Dev_journal. We’re particularly keen to see collaborations between junior and senior PIs, and between researchers who haven’t previously worked together.
My continued biomedical education
Multimodality imaging of large-vessel #Vasculitis
#GiantCellArteritis #TakayasuArteritis
Aorta/Coronary artery/Pulmonary artery
Echo
CT
MRI
18F-FDG PET
Dr. Jason Tarkin & Deepa Gopalan @Heart_BMJ 2022 @Jmtarkin
https://heart.bmj.com/content/early/2022/11/29/heartjnl-2022-321113
An impressive panorama of Trimethylamine N-oxide/TMAO on👤aortic #EndothelialCell
⏫Traits of #TrainedImmunity/Inflammation
Metabolic reprogramming
Kinome & transcriptional network
Intriguing role of PERK & mitoROS
In addition to Liver, Aorta (#SmoothMuscleCell/#Pericyte/Fibroblast/Mɸ?) may🤔 also oxidize #GutMicrobiota-derived trimethylamine/TMA into Trimethylamine N-oxide/TMAO
What is the local/Aortic vs circulating TMAO level?🧐
Wait for🐭tissue-specific KO of FMO3 (Oxidizing TMA)😆
Dr. Xiaofeng Yang lab JCI insight 2022
https://insight.jci.org/articles/view/158183
MRTF-A as a deacetylation target of Sirt6 in #EndothelialCell
Deactylated MRTF-A stays in cytoplasm, failing to mediate oxLDL-induced EC ICAM1
An OxLDL-DNMT1 cacade epigenetically silences Sirt6 expression
Dr. Qianyun Wang, Tianfa Li & Qianwen Zhao labs Cell Death Discov 2022
https://www.nature.com/articles/s41420-022-00903-y
Hao Yin
boosted
RT @fabian_theis@twitter.com
1/n Single-cell data analysis is complex with many tools to choose from - but which ones work best and should be used when? Led by @lukasheumos@twitter.com and @AnnaCSchaar@twitter.com, we wrote a free online book that aims to guide single-cell data analysts: https://sc-best-practices.org
🐦🔗: https://twitter.com/fabian_theis/status/1595810545365565447
#SIRT6 N308K/A313S, a #Centenarian variant
⏬deacetylase/deacylase
⏫mono-ADP-ribosylase
⏬LINE1 retrotransposition
⏫DNA repair
⏫tumor killing
Lamin A is mADP-ribosylated by Sirt6!
Love to explore its benefit over blood vessels!
Dr. Andrei Seluanov, Yousin Suh, Vera Gorbunova labs EMBO J 2022
https://www.embopress.org/doi/full/10.15252/embj.2021110393
Multi-agent-based computational modeling of #Lumenogenesis from a single proliferating cell
High Matrix density & dynamic viscosity->
Formation of multiluminal structure instead of a single cyst lumen
This is a very easy-to-read computational modeling paper (minimal math requirement😁)
Cell cycle/polarity/secretion
Cell-cell (attractive+repulsive) + cell-fluid interaction (repulsive) + cell-matrix interactions
Geometry & Biomechanics (but not biochemical property of matrix)
Dr. José Manuel García-Aznar lab Eng Comput 2022
https://link.springer.com/article/10.1007/s00366-022-01654-1
Hao Yin
boosted
CiliaMiner: an integrated database for Ciliopathy Genes and Ciliopathies https://www.biorxiv.org/content/10.1101/2022.11.28.518070v1?med=mas
K63 #Ubiquitination of #YAP by SKP2 #E3Ligase⏫its nuclear import🤠
Synergized with mTORC1-PERK-ATF4 axis in renal #Cystogenesis🐭#JuvenileCysticKidney #Ciliopathy
A #CellCycle-specific regulation of YAP?😆
Dr. Andrew Karaplis lab JCI 2022
https://www.jci.org/articles/view/153943
#MatrixStiffness (4 vs 11 kPa) of GelMA #Hydrogel Substrate regulates👤Lung Fibroblast
Proliferation
Cytoskeleton
Matrix deposition (Decorin/Collagen/Microfibril)
Secretome (IL6)
Fig 4↔️6?🧐
Dr. Janette Burgess lab Front Pharmacol 2022
https://www.frontiersin.org/articles/10.3389/fphar.2022.989169/full
Hao Yin
boosted
Exploring root branching in silico
A Research Highlight showcasing new work from Joana Santos Teixeira, Thea van den Berg and Kirsten ten Tusscher
Read the full #OpenAccess Research Article, ‘Complementary roles for auxin and auxin signalling revealed by reverse engineering lateral root stable prebranch site formation’ here: https://journals.biologists.com/dev/article/149/22/dev200927/283180/Complementary-roles-for-auxin-and-auxin-signalling
This article is available under our #ReadandPublish Open Access initiative.
Induced #EndothelialCell KLF4 KO in adult🐭->
Lung Inflammation+Fibrosis within 1 month😎
KLF4-KO EC has⏫KLF2 & #EndMT simultaneously!
Perturbed shear-sensing?
Link b/w⏫KLF2 & #EndMT?
EC secretome? So interesteing😆
Dr. Kishore Wary lab @FrontCellDevBio 2022 @KishoreWary
https://www.frontiersin.org/articles/10.3389/fcell.2022.1003028/full
A potential FGF9-TCF7L2 (#Wnt)-HAS2/#HyaluronicAcid cascade in #Palatogenesis #CleftPalate
GeneMANIA, a useful resource to explore gene relationships
http://www.genemania.org
Dr. Zhenqi Chen lab @Biomol_MDPI 2022
https://www.mdpi.com/2218-273X/12/11/1639/htm
Hao Yin
boosted
SlideCNA: Spatial copy number alteration detection from Slide-seq-like spatial transcriptomics data https://www.biorxiv.org/content/10.1101/2022.11.25.517982v1?med=mas
Itga8-CreERT2, a novel tamoxifen-inducible #SmoothMuscleCell-specific Cre🐭
Selective for Vascular over Visceral (GI/Airway...) SMC🤠
Critical comparison (+Aorta transcriptomes) vs Myh11-CreERT2
Dr. Qing Lyu & Joseph Miano labs Nature Cardiovascular Research 2022
https://www.nature.com/articles/s44161-022-00162-1
Hao Yin
boosted
#Oncology #oncologyresearch An estimated 1 million cancer diagnoses have been missed across Europe in the last 2 years.
With experts warning of a 'cancer epidemic in the next decade', a new @TheLancetOncol Commission outlines steps to strengthen the research landscape:
📌https://www.thelancet.com/commissions/European-Groundshot-cancer-research?utm_campaign=lanoncgroundshot22&utm_content=229456552&utm_medium=social&utm_source=twitter&hss_channel=tw-27013292
📌 https://www.thelancet.com/commissions?filterModify=true&journalFilter=&categoryFilter=lancet-clinical
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
