Joshua Sharp @JoshuaSharp@qoto.org

Superb structural glycobiology from Joel Bloch with Ethan Goddard-Borger & Kaspar Locher who solved the structure of tryptophan C-mannosyltransferase ! congratulations

https://www.nature.com/articles/s41589-022-01219-9

#glycotime

Everything about this story is just appalling: University administrators, and apparently even student journalists, have apparently decided that material a particular religious group considers “blasphemous” is therefore “harmful.” They cannot have thought through the consequences of applying that idiotic principle consistently. https://www.insidehighered.com/news/2023/01/03/debates-whether-academic-freedom-includes-images-offensive-muslims

Amid a raft of hospital closures, Mississippi Gov. Tate Reeves cautioned lawmakers against rushing to provide funding for ailing hospitals during a press conference on Jan. 3, 2023, saying that “keeping inefficient systems is not a good answer.”

https://www.mississippifreepress.org/30116/crisis-mode-as-hospitals-close-mississippi-lawmakers-mull-band-aid-fixes

Another HS polymerase structure, after the one from Rebekka Wild's group, late in 2022.

@strucbio #StructuralBiology #CryoEM #Glycotime
https://www.nature.com/articles/s41589-022-01220-2

UC strike energizes unprecedented national surge of union organizing by academic workers https://www.latimes.com/california/story/2023-01-02/uc-strike-energizes-labor-surge #academia

I know that facts don't matter so much during a moral panic, but I'll just say that I teach a class every year at Stanford that tackles hate speech, violence, terrorism, child exploitation, suicide and other really difficult topics and use a lot of these words with no difficulties.

I do give my students a talk up front about the content of the course and the need to be resilient if you want to make a positive impact in this field, but so far no complaints.

https://reason.com/2022/12/21/stanford-elimination-harmful-language-speech-karen-american/

#NSF Research Experiences for Undergraduates (#REU) at Clemson University in materials #chemistry summer 2023 https://scienceweb.clemson.edu/uacl/research-projects/reu/

BIG NEWS: Congress is ready to give the City of Jackson $600 million under the federal omnibus package—an enormous sum that would finally make addressing the Jackson water crisis and fixing the city's broken water system a reality.

@NickJudin@twitter.com reports: https://www.mississippifreepress.org/29778/congress-includes-600-million-for-jackson-water-system-in-omnibus-bill

We may never be able to match the incredible achievements of #JohnMastodon, but the European Union still plays its part!

We are proud funders of Mastodon through the Next Generation Internet initiative (@EC_NGI).

Open,
Interoperable,
Decentralised,
Trust based.

More info: https://www.ngi.eu/blog/2022/11/24/how-ngi-supports-open-interoperable-decentralised-and-trust-based-internet-applications-through-fediverse-projects-like-mastodon/

Happy holidays from my favorite mystery protein (PDB 6XF9) ❤️ 🔬 🧪

Six news websites across Alabama and Florida have been secretly taking payments from power companies to run stories attacking clean energy.

Bombshell investigation from NPR.

#energy #climate #climatechange
https://www.npr.org/2022/12/19/1143753129/power-companies-florida-alabama-media-investigation-consulting-firm

One of the biggest corruption cases ever came out of a San Diego Union-Tribune reporter noting something fishy about Rep. Duke Cunningham’s sale of a house. DC reporters never would have found it.

For anyone wondering, I'm still unable to access Twitter until I delete this tweet, which is factual journalism that doesn't even break the location rule Twitter enacted a few days ago. The account isn't marked as suspended anymore, but I can't use it or see tweets from people I follow. Using Mastodon exclusively for now and actually really enjoying it.

Please spread the word.

Assistant Professor in Integrative structural biology with focus on structural dynamics
Stockholm
Deadline Dec 28.

https://www.su.se/english/about-the-university/work-at-su/available-jobs

This is apparently the tweet that led to my suspension from Twitter. Right as I was reinstated they announced a new policy that they apparently found me to have retroactively violated
#twittermigration #twitterexodus #twitter #news #elonmusk #tech #technews #technology

Remembering the first and only time I made science themed cookies 😀 #cookies #dnagel #science

At least Elon Musk never shared links to his own Instagram account

Looks like the WSJ is going all in on moving to Mastodon, with this little tutorial available without a paywall.
https://www.wsj.com/story/how-to-use-mastodon-the-social-media-platform-blocked-by-elon-musks-twitter-7751455f

#StructuralBiologists are often experts at purifying recombinant #protein. I did not appreciate the value of that skill in #industry. Know your worth when you bring your knowledge to a company.

Some examples of outsourced proteins:
1) Fee-for-service (FFS) CRO catalog protein = $2500/mg. Later, we purified 20 mg from a 2L bacterial culture w/ standard purification protocol.

2) FFS purifying protein as part of #crystallography project. $8-10K per purification (with methods already established).