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4 yr PhD in Manchester, UK: The evolution of nerves: understanding the roots of neurodegeneration

TRAINING in evol. biol., biochem., expansion or electron microsc., cell culture, #Drosophila genetics, #scicomm

SUPERVISION: Prokop/Allan/Ronshaugen

DETAILS: thenode.biologists.com/jobs/pr

Hi #MedMastodon! 👋

#Introduction: I'm an #Endocrinologist at #Stanford, specializing in #Osteoporosis and #MetabolicBoneDisease. My lab studies #StemCells in bone 🦴 and the bone marrow microenvironment.

Some of my favorite topics: #WomenInMedicine #WomenInSTEM #PhysicianScientists #AAPI

Particularly relevant to the challenges imposed by the pandemic, women shoulder a disproportionate share of domestic tasks at home. Among K08/K23 recipients, women spend 8.5 hours more per week on domestic activities acpjournals.org/doi/10.7326/M1 6/n

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Every year, up to 4 billion hoverflies (80 tons in biomass!) migrate from Britain to Europe, providing important pest control by consuming 3–10 trillion aphids, as well as long-range pollen transfer. #Biodiversity
bit.ly/3Vi6LNJ

Exciting 4 yr BBSRC DTP PhD opportunity: investigating the links between cytoskeletal & mitochondrial homeostasis during ageing. A multidiscipl. collab. of 2 experienced groups: Sanchez-Soriano (Liverpool) & Korolchuk (Newcastle). DEADLINE: Mon, 9 Jan '23

findaphd.com/phds/project/inve

The impact of exercise on the brain was brought into focus, for me, by Stryker's lab work on approaches to recover from long-term vision deprivation through visual training while exercising physically ("stimulated by locomotion").

The underlying mechanism seems to be "the reduction produced by deprivation in thalamocortical excitation is compensated for during recovery by a corresponding reduction in the magnitude of inhibition."

Stryker wrote a review here:

"A neural circuit that controls cortical state, plasticity, and the gain of sensory responses in mouse" Stryker 2014 symposium.cshlp.org/content/79

Related, given that awake animals are often on the move:

"We have now studied the response properties of neurons in primary visual cortex of awake mice that were allowed to run on a freely rotating spherical treadmill with their heads fixed. Most neurons showed more than a doubling of visually evoked firing rate as the animal transitioned from standing still to running, without changes in spontaneous firing or stimulus selectivity."

"Modulation of visual responses by behavioral state in mouse visual cortex", Niell and Stryker 2010 sciencedirect.com/science/arti

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Cortical area instability–experiments in monkeys 

On the instability (plasticity?) of cortical areas, just got reminded of this classic work:

"Somatosensory cortical map changes following digit amputation in adult monkeys", Merzenich et al. 1984 onlinelibrary.wiley.com/doi/ab

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New to Mastodon? Here's an overview of privacy and security questions for this new way of doing social media. eff.org/deeplinks/2022/11/mast

I want to tell you the story of Vivienne Malone-Mayes, Texas-born mathemetician and professor, but I don't think you can understand her journey without talking about the #AcademicRacism in which she existed.

Job post 

We are hiring an editor!

Do you have a background in ecology or evolution, and want to be involved in a broader range of topics than your own research area?

We are particularly keen to extend the geographical representation of our editorial team (see some possible locations in the job ad below).

careers.springernature.com/job

“Exercise increases information content and affects long-term stability of hippocampal place codes” in mice. But the implications are tantalising.

Rechavi et al. 2022 doi.org/10.1016/j.celrep.2022.

This hard finding stands out: runners showed increased neurogenesis in their hippocampus.

“To assess the levels of hippocampal neurogenesis, we injected mice with Bromodeoxyuridine (BrdU), a marker for proliferating cells. In accordance with previous results (van Praag et al., 1999b), we found a higher number of BrdU-positive cells and increased labeling density of doublecortin (DCX), a protein transiently expressed in newborn neurons, in the DG of runners (Figures 1B–1D). This increase in adult neurogenesis indicates that physical activity affected the physiology of hippocampal circuits in our experiments.”

#behavioural time-scale #synaptic #plasticity was discovered by Bittner and Magee a few years ago: science.org/doi/full/10.1126/s

It was mysterious - how could the time-window for plasticity be so large?

This new paper from the Losonczy lab suggests that it's due to intracellular calcium release from the ER:

science.org/doi/abs/10.1126/sc

#introduction 🤓

I am a physicist specialized in #fluiddynamics and #solidmechanics with experience in #interdisciplinary research and #neuroscience. I develop modelling tools to predict #fluidstructure interactions in the #brain.

My research focuses on the role of intracranial vessel pulsation in #neurodegenerative diseases. I am highlighting how measurements of intracranial fluid dynamics combined with #biomechanics modelling can help to better understand and characterize brain #ageing.

Hi #ScienceMastodon!

My name is Meike and I am a postdoc studying cerebellar development and its role in neurodevelopmental movement and affective disorders.

Looking forward to meeting you and learning about your cool work!

Follow me for stories about and pretty pictures of the cerebellum.

#Science #Introduction #Cerebellum #womeninstem

🚨 BIG EXOPLANET NEWS! 🚨

Our team has released FIVE papers today on the most COMPREHENSIVE study of an #exoplanet atmosphere to date!

Using #JWST we obtained four transit observations of #WASP-39b early in the telescope's operations to study both the planet itself, and the telescope's capabilities to observe exoplanet atmospheres.

We detected numerous molecules in the planet's atmosphere, including CO2, CO, H2O, and SO2 🧵

The future is here! ⭐ 🪐 🔭 #Astrodon #Science

webbtelescope.org/contents/new

‘Eat local’ is a common recommendation to reduce the carbon footprint of your diet.

But transportation makes up a very small amount of the greenhouse gas emissions from food.

*What* you eat is far more important than *where* your food traveled from.

ourworldindata.org/food-choice

Such a beauty 🤩 Looking at one of the earliest #Zeiss microscopes 🔬 with #ErnstAbbe’s equation stating the #diffractionlimit in the background at the Museum of #Optics in Oberkochen - It is always fascinating to learn about the history of #science & #technology - #superresolution #microscopy #photonics 👉 zeiss.com/corporate/int/about-

Defining brain functions is a top-4 challenge for brain research. Conversations with my co-author @amygdaloid have made me realize why. Among the big topics, I suspect that it's the most underappreciated.

Why does it matter? We summarize it here (share link):
authors.elsevier.com/a/1g7Zrbo

Beautiful paper on choanoflagellate revealing the enigmatic ciliary vane, new components and similarities to animal cilia

elifesciences.org/articles/781

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