"This observation raises a question of fundamental importance: if natural mucosal respiratory virus infections do not elicit complete and long-term protective immunity against reinfection, how can we expect vaccines, especially systemically administered non-replicating vaccines, to do so? This is a major challenge for future vaccine development, and overcoming it is critical as we work to develop “next-generation” vaccines."

Perspective @cellhostmicrobe by David Morens, Jeffery Taubenberger & Anthony Fauci

#Vaccines #PublicHealth #Vaccine Development #Virus #Virology #Immunology #Coronavirus #Covid #Covid19 #Influenza #RespiratoryVirus #MucosalImmunology

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00572-8