Gaspar Jekely @jekely@qoto.org
- Platynereis connectome
- https://catmaid.jekelylab.ex.ac.uk
Professor at Centre for Organismal Studies (COS), University of Heidelberg, Germany
and
Living Systems Institute (LSI), University of Exeter, UK.
#neuroscience of marine larvae, #connectomics, #cilia, ciliary swimming, cell and nervous system #evolution, #GPCR, #neuropeptides, #Platynereis, #Trichoplax, #Nematostella, #Schistosoma, #coral #neuroscience #rstat #evolution
Joined Nov 2022
Sanja skeletonised all the 853 muscle cells in the larva and annotated their desmosomes and the partner cells and extracellular structures that the desmosomes attach to. This resulted in a single network of over 2,000 cells and extracellular structures (basal lamina, chitin endoskeleton etc) that we call the desmosomal #connectome. In synaptic connectomes the links are formed by #synapses, in a desmosomal connectome the links are desmosomes.
The revised version of our paper on the desmosomal #connectome of the #Platynereis larva is now out
https://elifesciences.org/articles/71231
by Sanja Jasek et al.
#volumeEM #rstat
Gaspar Jekely
boosted
I'm rebuilding my science network, so could everyone in the following areas please give a toot?
- #molecularevolution
- #computational #genetics
- #evolutionaryecology
- #mathemathicalmodelling
- #epiverse #epidemiology
- #palaeovirology
- #dinosaur #palaeontology
- #epigenetics
Gaspar Jekely
boosted
Our new preprint on the deeply conserved structure, and evolution, of insect Gustatory and Odorant receptors. The plethora of chemosensors in insects may be the result of extreme and rapid diversification of a single branch of a diverse superfamily of Eukaryotic (including human!) receptors, dating to at least LECA. An exceptionally fun collaboration with @bentonlab@twitter.com come to fruition! https://doi.org/10.1101/2022.12.13.519744
Gaspar Jekely
boosted
Still finding my bearings here.
Gaspar Jekely
boosted
Finally taking the time for an #introduction on #mastodon !
I'm a #marine #microbiologist currently leading a #lab at the #EMBL #Heidelberg. My lab is fascinated by the #diversity & #impact of #microbial #interactions across #biological scales, with a particular focus on #eukaryotic #phytoplankton. We think about #symbiosis #epibiosis #viralinfection #singlecell #ecology, often wt #TaraOceans folks⛵
I push for #inclusive #science, and to rethink our #practices in light of #sustainability 🌊
Gaspar Jekely
boosted
Ok, my masterplan for my 🐘 transition:
(1) I turn off all notifications NOW. Their draw is strong!
(2) I turn off tweet/toot syncing in January ‘23 and post links to my toots to reach you all for key announcements.
(3) I much hope to see the still missing ones there soon. ❤️
Gaspar Jekely
boosted
RT @HillmanLab
So excited to finally be able to share that @LeicaMicro and @ASIImaging have partnered to produce an amazing 'Single Objective Light Sheet' platform for gentle, high-speed 3D microscopy. Hoping it will bring the power of SCAPE and OPM to labs worldwide🔬https://www.leica-microsystems.com/company/news/news-details/leica-microsystems-and-asi-announce-partnership/ https://twitter.com/jsdaniel02/status/1599498412461674496
Gaspar Jekely
boosted
RT @bengallusser@twitter.com
Check out our work on rapid automated organelle segmentation in volume EM, great to see this published in @JCellBiol@twitter.com. And on top of that we have released all code, models and datasets 🎉https://github.com/kirchhausenlab/incasem https://twitter.com/KirchhausenLab/status/1599792365601845248
🐦🔗: https://twitter.com/bengallusser/status/1599798548849008640
New #cryoET structure from LSI Exeter colleagues Matthew Gaines et al. Bertram Daum lab, this time of the enigmatic #archaeal filament called 'thread'.
What I find cool about this work is that first they had the structure, then found the sequence based on glycosylation sites and bulky residues.
This #protein was also so ultra-stable, that resisted trypsinisation, so mass spec was not an option to identify it.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715654/
Gaspar Jekely
boosted
#introduction
I'm a theoretical neuroscientist in Paris.
These days I'm working on biophysics of action potentials (particularly the initial segment) and on integrative modeling of Paramecium, the “swimming neuron” (this is a unicellular protist that changes swimming direction with action potentials).
I also spend some time thinking about the relations between theoretical biology and theoretical neuroscience, ideas about life and ideas about brains.
@ecological_fallacy Okabe_Ito <- c("#E69F00", "#56B4E9", "#009E73", "#F0E442", "#0072B2", "#D55E00",
"#CC79A7", "#000000")
Tol_muted <- c('#88CCEE', '#44AA99', '#117733', '#332288', '#DDCC77', '#999933',
'#CC6677', '#882255', '#AA4499', '#DDDDDD')
are great colour-blind-friendly combinations, us the opposite ones for pairs
pie(rep(1,8), col=Okabe_Ito, Okabe_Ito, main='Okabe Ito')
Gaspar Jekely
boosted
3,013 neurons, half a million synapses: the complete #connectome of the whole #Drosophila larval brain!
Winding, Pedigo et al. 2022. "The connectome of an insect brain" https://www.biorxiv.org/content/10.1101/2022.11.28.516756v1
We’ve mapped and analysed its circuit architecture, from sensory neurons to brain output neurons, as reconstructed from volume electron microscopy, and here is what we found. 1/
Gaspar Jekely
boosted
Not nearly enough #protists and #cilia in this universe yet... let's rectify this with an inaugural edition of #CiliaSaturday 😍
Look at all its beautiful 'feet'... !
Gaspar Jekely
boosted
New postdoc position to join my group at the Sars Centre, in #SunnyBergen https://www.jobbnorge.no/en/available-jobs/job/236193/postdoctoral-research-fellow-position-developmental-systems-in-a-simple-marine-chordate
Our review with Stefan Gründer and Audrey Ortega Ramírez is out:
"Neuropeptides and DEG/ENaC ion channels: a relationship from mammals to cnidarians"
where we conclude based on structural comparisons and the #phylogeny of #neuropeptide systems that the interaction of DEG/ENaC channels with neuropeptides has diverse structural bases and many origins.
Gaspar Jekely
boosted
@jekely too late. I deleted my Twitter account. Why keep feeding the troll? Engagement earns them ad revenue.
Gaspar Jekely
boosted
Hi, we're now on Fediscience! #Introduction
We're an #OpenAccess not-for-profit journal that publishes and reviews #research in the life and biomedical sciences.
We want to improve the way research is practised and shared in part by working with early-career researchers #ECR and supporting #OpenSource technology.
We also just announced our new publishing model that we hope will tackle an overreliance on journal titles and publishing decisions as quality measures for science and scientists.
@balazsaczel sure, please do!
Gaspar Jekely
boosted
- Platynereis connectome
- https://catmaid.jekelylab.ex.ac.uk
Professor at Centre for Organismal Studies (COS), University of Heidelberg, Germany
and
Living Systems Institute (LSI), University of Exeter, UK.
#neuroscience of marine larvae, #connectomics, #cilia, ciliary swimming, cell and nervous system #evolution, #GPCR, #neuropeptides, #Platynereis, #Trichoplax, #Nematostella, #Schistosoma, #coral #neuroscience #rstat #evolution
Joined Nov 2022
