Gaspar Jekely @jekely@qoto.org
- Platynereis connectome
- https://catmaid.jekelylab.ex.ac.uk
Professor at Centre for Organismal Studies (COS), University of Heidelberg, Germany
and
Living Systems Institute (LSI), University of Exeter, UK.
#neuroscience of marine larvae, #connectomics, #cilia, ciliary swimming, cell and nervous system #evolution, #GPCR, #neuropeptides, #Platynereis, #Trichoplax, #Nematostella, #Schistosoma, #coral #neuroscience #rstat #evolution
Joined Nov 2022
Gaspar Jekely
boosted
Wanted to share our recent paper on how a cell, Chlamydomonas, "knows" when its flagella are removed. When flagella are detached in this unicellular alga, they grow back in an hour, and while that happens a whole program of genes are turned on. Here we show that induction depends on intraflagellar transport, suggesting a model in which a repressor is sequestered in flagella when they are re-growing, and then accumulates to turn genes off as growth tapers off.
https://www.molbiolcell.org/doi/10.1091/mbc.E22-09-0444
Gaspar Jekely
boosted
Elsevier appears to be collecting and monetizing our personal data, sometimes without our consent. The data they collect can be used to "extrapolate core working hours, vacation times, and other patterns of a person’s life."
What can we do?
Over 20,000 researchers are refusing to publish, review, or edit for Elsevier. You can also ask them to delete your "non-integral" personal data: https://www.elsevier.com/legal/privacy-policy/data-request
Article by @eikofried https://eiko-fried.com/welcome-to-hotel-elsevier-you-can-check-out-any-time-you-like-not/?=IwAR3DJSxwVn4OQB_HcRr8uNS1szepCAWy_9wbJo3Hi_ZcfdBN-trs6ndgmJo
#OpenScience @academicchatter
Application for participation now open for the Janelia "Neuropeptide Signaling: Bridging Cell Biology, Neurophysiology, and Behavior" #meeting in April 16 - 19, 2023.
Deadline: Jan 18
https://www.janelia.org/you-janelia/conferences/neuropeptide-signaling-bridging-cell-biology-neurophysiology-and-behavior
#Neuropeptide #Neurophysiology #Neuroscience
Gaspar Jekely
boosted
Excited to share our new manuscript on a novel #neuropeptide family that regulates #feeding across #evolution. Kudos to #Pat_TFrancisco for tackling this challenging project and coming up with the name #marmite. #homeostasis https://www.biorxiv.org/content/10.1101/2022.12.12.520095v3 Still figuring this space out. In the meantime if you want to check out the thread on the competing platform (links to the competition are allowed here?). https://twitter.com/RibeiroCarlitos/status/1605147211918196736 #drosophila
Gaspar Jekely
boosted
The website for ICIV 2023 hosted by the Lund Vision Group is online at: https://iciv.se
July 27 to August 3 in 2023 – at Bäckaskog Castle, Sweden.
Abstract submission will open January 1. Mark your calendars!
Gaspar Jekely
boosted
Hello world!
I have been studying cilia since 2005, been modestly active on Twitter since 2014 and will be posting about anything related to #cilia, #signaling, #BardetBiedlSyndrome
In this paper we generated most of the figures entirely in R for open science and reproducibility. All code is shared here:
https://github.com/JekelyLab/Jasek_et_al
The figures and analyses can be regenerated by the code that will query our public #CATMAID database where all EM data, tracings and annotations are shared:
https://catmaid.jekelylab.ex.ac.uk (project id: 11)
#openscience #rstat
We also mapped #motoneuron synapses to the desmosomal connectome to infer the extent of tissue influenced by motoneurons. We suggest that such cellular-level maps based on #volumeEM data and the integrative analysis of synaptic and adherent force networks will be important to elucidate body mechanics and the nervous control of movement.
The #endoskeleton formed by the #aciculae and supported by many muscles is quite unique to polychaete annelids and represents the only example outside the #tetrapods of animals with a trunk appendages rigidified by an endoskeleton. Aciculae evolved in stem errant #annelids in the Early #Ordovician indicating the deep ancestry of these structures, predating tetrapod limbs.
We analysed the network in many different ways and found that its structure is quite different from the synaptic #connectome and random networks. One of the interesting findings was that the #aciculae - chitin rods that form an #endoskeleton in the segmental #appendages - are highly connected hubs in the #network and a large number of #muscles is involved in moving them.
Sanja skeletonised all the 853 muscle cells in the larva and annotated their desmosomes and the partner cells and extracellular structures that the desmosomes attach to. This resulted in a single network of over 2,000 cells and extracellular structures (basal lamina, chitin endoskeleton etc) that we call the desmosomal #connectome. In synaptic connectomes the links are formed by #synapses, in a desmosomal connectome the links are desmosomes.
The revised version of our paper on the desmosomal #connectome of the #Platynereis larva is now out
https://elifesciences.org/articles/71231
by Sanja Jasek et al.
#volumeEM #rstat
Gaspar Jekely
boosted
I'm rebuilding my science network, so could everyone in the following areas please give a toot?
- #molecularevolution
- #computational #genetics
- #evolutionaryecology
- #mathemathicalmodelling
- #epiverse #epidemiology
- #palaeovirology
- #dinosaur #palaeontology
- #epigenetics
Gaspar Jekely
boosted
Our new preprint on the deeply conserved structure, and evolution, of insect Gustatory and Odorant receptors. The plethora of chemosensors in insects may be the result of extreme and rapid diversification of a single branch of a diverse superfamily of Eukaryotic (including human!) receptors, dating to at least LECA. An exceptionally fun collaboration with @bentonlab@twitter.com come to fruition! https://doi.org/10.1101/2022.12.13.519744
Gaspar Jekely
boosted
Still finding my bearings here.
Gaspar Jekely
boosted
Finally taking the time for an #introduction on #mastodon !
I'm a #marine #microbiologist currently leading a #lab at the #EMBL #Heidelberg. My lab is fascinated by the #diversity & #impact of #microbial #interactions across #biological scales, with a particular focus on #eukaryotic #phytoplankton. We think about #symbiosis #epibiosis #viralinfection #singlecell #ecology, often wt #TaraOceans folks⛵
I push for #inclusive #science, and to rethink our #practices in light of #sustainability 🌊
Gaspar Jekely
boosted
Ok, my masterplan for my 🐘 transition:
(1) I turn off all notifications NOW. Their draw is strong!
(2) I turn off tweet/toot syncing in January ‘23 and post links to my toots to reach you all for key announcements.
(3) I much hope to see the still missing ones there soon. ❤️
Gaspar Jekely
boosted
RT @HillmanLab
So excited to finally be able to share that @LeicaMicro and @ASIImaging have partnered to produce an amazing 'Single Objective Light Sheet' platform for gentle, high-speed 3D microscopy. Hoping it will bring the power of SCAPE and OPM to labs worldwide🔬https://www.leica-microsystems.com/company/news/news-details/leica-microsystems-and-asi-announce-partnership/ https://twitter.com/jsdaniel02/status/1599498412461674496
Gaspar Jekely
boosted
RT @bengallusser@twitter.com
Check out our work on rapid automated organelle segmentation in volume EM, great to see this published in @JCellBiol@twitter.com. And on top of that we have released all code, models and datasets 🎉https://github.com/kirchhausenlab/incasem https://twitter.com/KirchhausenLab/status/1599792365601845248
🐦🔗: https://twitter.com/bengallusser/status/1599798548849008640
New #cryoET structure from LSI Exeter colleagues Matthew Gaines et al. Bertram Daum lab, this time of the enigmatic #archaeal filament called 'thread'.
What I find cool about this work is that first they had the structure, then found the sequence based on glycosylation sites and bulky residues.
This #protein was also so ultra-stable, that resisted trypsinisation, so mass spec was not an option to identify it.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9715654/
- Platynereis connectome
- https://catmaid.jekelylab.ex.ac.uk
Professor at Centre for Organismal Studies (COS), University of Heidelberg, Germany
and
Living Systems Institute (LSI), University of Exeter, UK.
#neuroscience of marine larvae, #connectomics, #cilia, ciliary swimming, cell and nervous system #evolution, #GPCR, #neuropeptides, #Platynereis, #Trichoplax, #Nematostella, #Schistosoma, #coral #neuroscience #rstat #evolution
Joined Nov 2022
