As second Appendix to my #introduction, I would like to #boost our recent #DrugDiscovery efforts in the development of #BroadSpectrum #Antivirals.
#SarsCov2 #ZIKV #Rhinovirus #enterovirus
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100483
Hey #ChemiVerse
Nature Chemistry is recruiting for a full-time editor!
The ideal candidate will have expertise in chemical biology or biological chemistry.
Closing date for applications: 12th December
Locations: London, Berlin, New York, Shanghai
#Editorial #Publishing #Chemistry #Jobs #ScienceJobs #ChemJobs
Boosts appreciated!
Some nice work from Ethan Toriki, James Papatzimas, Daniel Nomura and coauthors on bioRxiv https://www.biorxiv.org/content/10.1101/2022.11.04.512693v1
I think this is the first example in the “glue degraders” field where someone found a “degrading handle” that could be attached to multiple different inhibitors to give degradation of different proteins. A nice step forward in the rational design of molecular glue degraders!
As appendix to my #Introduction and catalyst for possible collaborations in the field, I would like to #boost our recent #DrugDiscovery effort in the modulation of the #CCL20/#CCR6 axis to identify new #inhibitors for #IBD and other #diseases depending on the same axis.
https://www.sciencedirect.com/science/article/abs/pii/S0223523422006055
🔬🧬 Italy's research institute for #LifeSciences based in Palazzo Italia, Milan.
👨🔬 👩🔬 Our mission is to promote human health & well-being.
#lifescience #science #genomics #neuroscience #biology #computationalbiology #structuralbiology #datascience #biostatistics #molecularbiology #microbiology #bioinformatics #cryoem #cryoet #machinelearning #openscience #scicomm #crispr #genetics #organoids #medicine #publichealth
An excellent overview on #coxsackievirus targeting drugs.
https://onlinelibrary.wiley.com/doi/epdf/10.1002/rmv.2406
Hello Mastodon! This is the official account for the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).
We are a non-profit org focused on #InfectiousDisease and Clinical Microbiology for professionals in those areas.
We organise research grants, educational events and our annual congress #ECCMID2023 (www.eccmid.org) along with much more.
You can learn all about us on our website (www.escmid.org) and we hope to see you around!
Another excellent business opportunity for our birdy-friend: https://pubs.acs.org/doi/10.1021/cen-10040-cover
RT @UZH_Chemistry@twitter.com
@Simon__Sieber@twitter.com and co-authors @UZH_Chemistry@twitter.com developed the first catch-enrich-release approach that results underivatized amine-containing compounds as products published @ChemCommun@twitter.com: https://pubs.rsc.org/en/content/articlelanding/2022/CC/D2CC04905H
🐦🔗: https://twitter.com/UZH_Chemistry/status/1592509956217266178
Animal models for long Covid, review at #PlosPathogens
"We review SARS-CoV-2 infection and disease manifestations in mice, Syrian hamsters, ferrets, and nonhuman primates (NHPs). Specifically, the virology, pathology, immune responses, and multiorgan involvement are summarized. These models are rationally examined for their use in understanding the complexities of the multiorgan involvement during Long COVID and the potential for their use in screening therapeutics such as anti-inflammatory drugs, which are currently used for treating other diseases. The aim of this review is to highlight Long COVID preclinical animal models that could be used for Long COVID research and to screen for pharmacological interventions."
#Covid19 #LongCovid #Covid #SarsCoV2
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741
RT @KFBChem@twitter.com
KFB Lab Alert: Our first independent research report on the Decarboxylative Bromooxidation of Indoles by a Vanadium Haloperoxidase is now available @ChemRxiv@twitter.com!
A massive congratulations to the team! Much more coming soon!
https://chemrxiv.org/engage/chemrxiv/article-details/636d5775deff974544df4bf0
I'm an assistant #Professor at the University of York. I lead a team researching how steroid hormones drive breast cancer tumour growth.
I've shifted fields a lot over my career, originally I was an organic chemist, and then during my #PhD I used those skills to look at bacteria that make antibiotics.
With the growth of 'omics technologies, I got into #genomics and #proteomics which now underpins our cancer research work.
See link for nice curated lists of academics on Mastodon, with subjects ranging from Astrophysics to History to Law to Medieval History to Neuroscience.
Thank you to @hendrikerz and @perspektivbrocken for maintaining it.
We are looking for one or two more post-docs to work on the role of inner membrane association in Vibrio cholerae transcription regulation or communication between the host intestine and intestinal bacteria. Your pic here?😁 https://paulawatnicklab.com for contact info
Intro: Currently lead of Research IT at a large BioTech located in Boston Seaport. Prior: Led automation, data sci, catalysis, HTE crystallization, and biocatalysis group in process chemistry at BMS for 10 years. Before was at Merck process working in biocatalysis (claim to fame was leading the transaminase development for sitagliptin manufacture). Ph.D. Organic Chemsitry (Harvard, Dave Evans 2003). B.S. Chemistry (UChicago, Rawal 1998) #ChemiVerse
Possible applications of #MultiTarget compounds in #ProxPharm Beyond PROTACs.
https://www.sciencedirect.com/science/article/pii/S2001037022005049
What is Mastodon?
What are the pros and cons of Mastodon over Twitter?
Should I make the switch?
All that and more in our latest blog!
#academia #PhD #science #xp @OpenAcademics @AcademicChatter
Read it here:
https://thestrugglingscientists.com/mastodon-for-academics/
#IDMastodon #Kinases key regulators of the #innateimmunity.The discovery of novel small molecule modulators is critical to new Tx for #antiviral and #cancer #Immunotherapy. The Transcreener ADP2 Kinase Assay can help accelerate these efforts due to its robust flexibility for #DrugDiscovery
https://offers.the-scientist.com/hubfs/TS_PPL_Bellbrook_Kinases_Article/Targeting_Kinases_Involved_in_the_Innate_Immune_Response.pdf?utm_referrer=https%3A%2F%2Foffers.the-scientist.com%2F by @TheScientistLLC
#Introduction — I am a Professor of #EvolutionaryBiology at #UniversityOfManchester UK. My lab studies the #evolution and #ecology of microbes and microbial communities. We mostly use #ExperimentalEvolution and #Genomics
#adaptation #diversification #coevolution #symbiosis #mutualism #parasitism #microbiome #MicrobialGenomics #HorizontalGeneTransfer #HGT #plasmid #phage #bacteria #protists #algae #Pseudomonas #AntimicrobialResistance #AMR #CysticFibrosis #bronchiectasis
Professor of Medicinal Chemistry at the University of Parma (Italy).
Developing novel drug candidates for Chronic and Infective Diseases.
Interests:
#MedChem #MedicinalChemistry #DrugDiscovery #Chemistry #MultiTarget #Antiviral #Antibacterial #Anticancer #IBD #CVD #Alzheimer #CysticFibrosis #Medicine #Pharmacology #Biotech #ccr6 #pcsk9 #bsaa