Philipp Schlegel @uni_matrix@qoto.org

Thrilled to share the lab’s first paper, which just came out in
Current Biology: https://authors.elsevier.com/a/1gKNX3QW8R%7Efdk
This project, spearheaded by postdoc extraordinaire
Sander Liessem, was our first foray into the world of #insulin signaling in #Drosophila. Just like in humans, worms, and mice, insulin is key to regulating #fly metabolism. Different from vertebrates, however, a major population of insulin-producing cells (IPCs) sits right on top of the fly’s brain and releases insulin into circulation.

Exciting New Year's release of #BigStitcher! It now supports:

1) efficient blocked processing, meaning large, tiled acquisitions are fused blazingly fast (second/minutes instead of hours)!

2) Export of ZARR/N5/HDF5 thanks to the N5-API

Check it out, just update Fiji!

What will happen if we’ll RETHINK our street corners?

We'll realize that until now, we've made them too car-centric. Street corners are designed for fast driving, which means pedestrians have to risk their safety just to cross the street.

But if we’ll rethink our street corners we’ll get

■ More space for pedestrians
■ Shorter crossing distance and time
■ Greener spaces
■ Safer Streets
■ Beautiful street corners

A great example from PGAA Creative Design in Manila

Behind Blue Eyes

Did you know that reindeer are the only known mammal whose eyes change seasonally from golden in the summer to a wintry blue? Their eyes also become a thousand times more sensitive in winter, adapting to dim light in the near darkness to avoid predators.

Part of this is because of changes in the tapetum lucidum (TL), a mirror-like layer under the retina. 1/n

#ScienceSunday #ScienceMastodon #Christmas

I got curious about #ChatGPT and the associated questions related to ownership - so I quickly created a #German #cookbook with outstanding recipes by asking #ChatGPT questions and DALL-E to generate images ... check it out

https://drive.google.com/file/d/17DXeTqENrpP3sHQouPMQ8bujsVYp0Wdp/view?usp=sharing

We are hiring a new endowed Professor in the Indiana University Gill Center! Come join us in an extremely collegial and collaborative environment. We are six chairs working on cellular and molecular neuroscience from various departments across campus Will you be the 7th?! Feel free to DM for details & Please Retoot!

Don’t know who took this shot but it’s kinda epic: a Great Grey Owl lands on a photog’s camera.

New preprint for the lab! We introduce GelMap, a method enabling intrinsic calibration and deformation mapping for expansion microscopy.

https://www.biorxiv.org/content/10.1101/2022.12.21.521394v1

make better choices

Can anyone from the #xenopus community describe this technique in more detail?

If you are interested in today and future applications of X-ray imaging for life sciences, register now for the LEAPS Meets Life Sciences Conference in Italy next year: https://agenda.infn.it/event/33026/

The revised version of our paper on the desmosomal #connectome of the #Platynereis larva is now out
https://elifesciences.org/articles/71231
by Sanja Jasek et al.
#volumeEM #rstat

I can't stop posting on Twitter because my followers is the new I can't stop publishing with Elsevier because my career.

The dilemma of whether or not to take individual action when only collective action will solve the problem.

Here is my #introduction. I am a biologist interested in #neuroscience and the #evolution of cells and nervous systems. My research group studies #ciliated marine larvae from a whole-organism perspective, combining behaviour, #connectomics, #imaging, #CRISPR, #modelling and other approaches. We love marine #larvae, their #neurons, #cilia, and #neuropeptides.

Going forward, #DeepLabCut updates will come via medium (and GitHub of course), but not the bird. This is sad, as the science Twitter community, I believe, was so important in getting out the word early on our very first code release and paper. But, it’s not okay anymore 💔…

📣🚨To get the latest updates on our code releases going forward, please see our medium blog http://www.deeplabcut.medium.com and all resources linked on our homepage: http://DeepLabCut.org - take care #deeplabcutters 🙏🏼💜

In Alaska, wood frogs freeze for seven months, thaw and hop away.

https://www.latimes.com/science/sciencenow/la-sci-sn-alaskan-frozen-frogs-20140723-story.html

#naturephotography #nature #frogs #alaska

'Using Drosophila melanogaster wing shape, we ask if we can replicate allelic effects of polymorphisms first identified in a GWAS (Pitchers et al. 2019) in three genes: dachsous (ds ), extra-macrochaete (emc) and neuralized (neur), using artificial selection in the lab and bulk segregant mapping in natural populations.'

#Preprint #Evolution #GeneticVariation #Adaptation #Preprint #Drosophila
https://www.biorxiv.org/content/10.1101/2022.05.12.491649v2

It's really cool that Twitter shuts down in stages over two months so that the Mastodon servers aren't overloaded all at once, very thoughtful of them!

Olfactory sensory neurons (OSNs) “undergo depolarization block as part of their normal physiological function…enter depolarization block at odor concentrations 3 orders of magnitude above their detection threshold, thereby defining receptive fields over concentration bands.“

Lots of implications for perceptual discrimination in olfactory space.
Experiments and modeling in #Drosophila larva.
Tadres et al. 2022, Matthieu Louis lab. https://www.science.org/doi/10.1126/sciadv.ade7209
#neuroscience

UC postdocs got a 20% raise:

University of California Academic Workers Partly End Strike

https://nyti.ms/3PjWwH4