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@lhgmk2

I'm trying to figure something like this out. It's a 10 hour drive and I only have 12 pieces of furniture that we're bringing that don't fit in our car.

I'm asking for quotes from a couple movers and we'll see if the sticker shock kills me.

@OpenComputeDesign

From what I'm hearing they basically only rent them out in the winter. It's bizarre to me that they own cars that they won't rent out unless you promise never to go off of a paved road, but, here we are.

I'm trying to rent an AWD cargo van to move a few pieces of larger furniture and I'm finding that all of the rental places that have them, put them behind a "call for details" so you can't reserve them online. As soon as I call they ask why I need an AWD or 4WD since it's winter time. I say that I'm moving off grid and I'm up a dirt "driveway"(call it a road and they immediately hang up on you) and they all freak out. "Take it off of the paved road and you're violating our terms of service!" :blobcatgooglyshrug:

#Covid day 3. The cat is losing her mind because I won’t let her into the isolation room. But I’ll be damned if I’m giving my cat Covid.

Y’all are going to roll your eyes, but just in case anyone needs to hear it, Amazon Clinic is a steaming pile of 💩. Get your Paxlovid prescription anywhere else.

I'm actually going to be brief here. Shocking, I know.

nytimes.com/2024/05/28/climate

I think these lawsuits will ramp up. I've been trying to get someone I know who's suffering, and has plenty of money, to start one himself.

I also think, based on discussions with actual lawyers previously, that there will be a day in court where in one room lawyers are saying, "Sure, you're unwell, but, how do you know that's from PFAs and not COVID?" While lawyers in the next room over are saying, "Sure, you're unwell, but how do you know that's from COVID and not PFAs?"

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So our family doctor asked us — while unmasked in their office — how long we were going to wear face masks in public places. WTF!

I am not a conspiracy theorist but I have lost confidence in our healthcare system. Still getting vaccinated BTW

#covid #PublicHealth #CdnPoli #NBPoli

May 27, 2024- “SARS-CoV-2 can directly invade the cardiovascular system through ACE2; Similarly, cardiovascular diseases such as hypertension and coronary heart disease can affect ACE2 levels and exacerbate the disease, and ACE2 dysregulation may also be a potential mechanism for long-term acute sequelae of COVID-19.” “..because ACE2 is widely distributed in the human body, novel coronavirus infection can not only affect the respiratory system, but also directly invade the cardiovascular system through ACE2, causing or even aggravating cardiovascular diseases.” “Although vaccines targeting SARS-CoV-2 have been produced, the risk of disease remains high for individuals with weakened immunity.” - frontiersin.org/articles/10.33

The possible mechanism and research progress of ACE2 involved in cardiovascular injury caused by COVID-19: a review

ACE2 is the earliest receptor discovered to mediate the entry of SARS-CoV-2. In addition to the receptor, it also participates in complex pathological and physiological processes, including regulating the RAS system, apelin, KKS system, and immune system. In addition to affecting the respiratory system, viral infections also interact with cardiovascular diseases. SARS-CoV-2 can directly invade the cardiovascular system through ACE2; Similarly, cardiovascular diseases such as hypertension and coronary heart disease can affect ACE2 levels and exacerbate the disease, and ACE2 dysregulation may also be a potential mechanism for long-term acute sequelae of COVID-19. Since the SARS CoV-2 epidemic, many large population studies have tried to clarify the current focus of debate, that is, whether we should give COVID-19 patients ACEI and ARB drug treatment, but there is still no conclusive conclusion. We also discussed potential disease treatment options for ACE2 at present. Finally, we discussed the researchers’ latest findings on ACE2 and their prospects for future research.

www.frontiersin.org

Just a reminder to check your local wastewater testing if it still exists. Ours does not, but the two closest to us on data.wastewaterscan.org are both straight vertical lines now. This new variant's wave looks like it's likely to be a big one. At least locally, brick and mortar schools are mostly finishing up this week. Maybe that'll alleviate some of the pressure.

N95 (vergelijkbaar met FFP3) mondneusmaskers en PCR testen zijn in ziekenhuis goedkoper dan chirurgische maskers en zelf-testen (en waarschijnlijk ook goedkoper dan geen maskers en geen testen).

"In other words, testing and wearing N95s to detect and prevent COVID can save lives and money because it reduces the costs of keeping patients in hospital for longer and replacing furloughed staff."

abc.net.au/news/2024-05-06/hun

SARS-CoV-2 "DeFLiRT" variant - LB.1 with Spike S31del mutation 

The new SARS-CoV-2 "FLiRT" lineage LB.1 (descended from JN.1.9.2) has acquired the Spike S31del mutation so becoming a "DeFLiRT". That deletion appears to be quite efficient, with strong growth in the US (14%) and now Canada (10%). New Zealand and Singapore have not updated any data since last week.

At present this seems the most likely successor to the currently-dominant "FLiRT" KP.2 and "FLuQE" KP.3.

#COVID19 #LB_1 #Spike_R31del #DeFLiRT
🧵

If I could teach my students one thing, it’s that you don’t have the power to stop people from making poor choices. And if they make poor choices after you’ve given them all the information and resources to make good choices, you have to let the responsibility lie with them. Save yourself the sleepless nights and guilt because it will burn you out in the end if you approach clinical practice with the idea that you can save people from themselves.

“Post-recovery from COVID-19, the immune system undergoes reconstruction. However, the elevated interferon responsive genes in monocytes can still be found after 4 months since the infection, which implies that the immune system is not fully recovered after 4 months…”

nature.com/articles/s41467-024

#covid #COVID19 #sarscov2

"Respirator" means a facemask that seals around the mouth and nose for the purpose of filtering all the air the wearer inhales.

Respirators can be constructed of either:

a) an elastomeric body designed to be reused many times with replaceable electrostatically-charged, glass fibre, charcoal and/or gas filters, straps, etc

b) an electrostatically-charged fabric designed to be disposed of after one or a small number of uses.

Most reusable elastomeric respirators (N95, FFP2, FFP3, P100) have exhalation valves, but some don't.

Most disposable fabric respirators (KN95, KF94, N95, FFP2, FFP3) don't have exhalation valves, but some do.

🧵

@maskup

#MaskUp #MaskMeansRespirator #WearARespirator #N95 #P100 #Respie #Elasto #CovidIsAirborne

I just found out season 2 of Outer Range is available!! I absolutely loved season 1, it was such a unique story (sci-fi western!). I guess I'll sign up for Prime for a month to watch it. Anything else new and good on prime right now? #SciFi #OuterRange

@datum

I know you're scientifically literate, so rather than dumbing it down some, tell me if this answers your first question:

asdwa.org/wp-content/uploads/2

If not, definitely ask more questions.

The basic answer to the activated charcoal vs. RO from my standpoint is two-fold.

One, in short, I've seen various tests with some different results. I think if you think about activated charcoal like column chromatography, length, time and temperature all matter. I've seen various numbers coalescing around 80-ish percent, though, and that's probably a fair number, but, real life results will differ.

Specifically, I've sent this to a couple of people because the supplementary data to this paper lists out some exact brands of filters that they used under real life conditions(it's not too hard to get the number you're looking for, for just one chemical in the lab). I stumbled on it looking for something else recently, and Berkey filters must be popular because at least three people asked me about it and they tested three of them, for instance.

pubs.acs.org/doi/suppl/10.1021

Two, I always have to say this even if you know it, RO's just more comprehensive. There's always stuff that you just don't know about in there, and RO's going to get more of it.

Honestly, the Swiss cheese approach works here, too. I have a whole home filter that filters everything coming into the house, and THEN I run the drinking/cooking/dishwashing/ice making water through RO.

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