ExplaiNN provided great insight into the wide range of IRF4 binding motifs, returning Importance scores that clearly highlight the novel motifs targeted by IRF4 9/12
The binding data showed in particular that the mutation was allowing the TF to stick to novel target sequences, most strikingly those having a GATA instead of a GATA in the motif 7/12
to show that the mutations were indeed causing IRF4 to stick to a much broader range of DNA sequences 6/12
RT @gobeirne
16 years ago, two future New Zealand Prime Ministers hanging out in Hyde Park, London. #nzpol
Interesting sign on top of Meridian Mall. Looks like there's an important story behind it. Perhaps a previous building? #DunedinSabbatical
RT @boris_ctcf
🎖An atlas of transcribed human cardiac promoters and enhancers reveals an important role of regulatory elements in heart failure.
Deviatiiarov, R.M., Gams, A., Kulakovskiy, I.V. et al.
Nat Cardiovasc Res (2023). https://doi.org/10.1038/s44161-022-00182-x
RT @saezlab
Building a knowledge graph for biomedical tasks usually takes months or years. 😰 What if you could do it in weeks or days? 🏃 We created BioCypher (https://biocypher.org) to make it easier than ever, but still flexible and transparent. 🧵⬇️
RT @CMA_Docs
The introduction of seamless, accessible electronic medical records is overdue.
To ensure the delivery of appropriate, effective care across the #CDNhealth system, @clairehsnyman underscored that patients and providers require timely access to the information they need.
RT @Scholar_Melinda
🌻🚨Excited to share I’ve joined the Geography & Atmospheric Science & Indigenous Studies Department @KUIndigenous at @UnivOfKansas where I’ll have my own lab to continue Indigenous environmental science research as a tenured track Prof! #AcademicTwitter #NativeTwitter #academia
RT @jburnmurdoch
NEW: conservatives have a Millennials problem.
In both UK & US, it’s not just that Millennials aren’t voting conservative because they’re young.
Every previous generation grew more conservative with age, but Millennials are not playing ball.
My column: https://enterprise-sharing.ft.com/redeem/a0c1c1b2-eda9-48b6-890a-2bac5ee6a9ac
RT @VisualCap
In our signature style—combining art, data, and storytelling—we've helped millions of people make sense of unfolding events, from geopolitical flare-ups to stock market turmoil 🌟
See our Top 22 Visualizations of 2022:
https://www.visualcapitalist.com/our-top-22-visualizations-of-2022/
1. World's Population at 8B
The Argentines were out in force tonight in Queenstown. Messi may have heard them. #DunedinSabbatical
Bioinformatics enthusiast, UBC professor, BC Children's Hospital scientist, He/Him