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Clément Goubert :verified:

Highly recommended!!!
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RT @guilbourque
Come work with us this summer! twitter.com/c3genomics/status/
twitter.com/guilbourque/status

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Clément Goubert :verified:

RT @hub_te
DATE CHANGE!!! Next update: Wednesday February the 8th (9AM PST // 12AM EST // 6PM CEST)

You can find the Zoom link in the -hub channel on TransposonsWorldwide Slack.

Join us to discuss developments of resources for TE Hub

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Clément Goubert :verified:

Previously unreported racist attack by a crowd including an elected city councilman in rural France
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RT @davidperrotin
« Il y a vraiment un sentiment d’omerta dans le village. Même le maire refuse de s’exprimer. Un maire qui protège son 2e adjoint qu’on voit pourtant tabasser un jeune de 24 ans. Et un député RN qui refuse de condamner ces violences. »
twitter.com/davidperrotin/stat

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Clément Goubert :verified:

🇧🇷 people! Reach out to @rita_rebollo :)
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RT @rita_rebollo
Viva Brasil! 5 week stay, lots of lab visits, and a nice collab with Claudia Carareto (of course)! Thanks CAPES! people from , let's hook up! @hub_te thinking of you!
twitter.com/rita_rebollo/statu

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Clément Goubert :verified:

RT @MarcoTodescoCnv
Look at this great postdoc opportunity! 😁 Come work with us on cannabis genetics and flowering time diversity in beautiful Vancouver (and help reduce cannabis' humongous carbon footprint, since you are at it). Also, new website! todescolab.msl.ubc.ca/ twitter.com/ubcmsl/status/1621

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Clément Goubert :verified:

RT @camerongenomics
VCF 4.4 IS NOW LIVE! 🧵

New to 4.4:
- Tandem repeat alleles
- Polyploid partial phasing
- Interchromosomal phasing
- Non-integer and allele-specific copy number
- Conceptual separation of variant detection and interpretation (EVENT/EVENTTYPE)

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Clément Goubert :verified: boosted
Physalia-courses

🥁Registration is now open for the course "Bioinformatic analysis of Transposable Elements" with Valentina Peona & @clementgoubert in June

🗓️ (online) June, 12-15

🔗physalia-courses.org/courses-w

💡 Attendees will learn how to conduct computational analyses of TEs, interpret the results in the light of TE biology, and improve TE annotations through manual curation

#TransposableElements #Genomics #Bioinformatics

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Clément Goubert :verified:

RT @Faulkner_Lab
Some quick thoughts on a "best practice" approach to find and measure transcripts with potential to express HERVK proteins: 1/n

(not saying this is the only way - please comment)

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Clément Goubert :verified:

Very cool! P-element invasions in Drosophila erecta shed light on the establishment of host control over a transposable element biorxiv.org/content/10.1101/20

P-element invasions in Drosophila erecta shed light on the establishment of host control over a transposable element

To prevent the spread of transposable elements (TEs) hosts have developed sophisticated defence mechanisms. In mammals and invertebrates this defence mechanism operates through piRNAs. It is unclear how piRNA-based defences are established against invading TEs. According to the trap model, a TE insertion into a piRNA cluster, i.e. a distinct genomic locus, activates the host defence. Alternatively, siRNAs, generated by cleavage of dsRNA, may be the trigger for host control. To investigate this we introduced the P-element, one of the most widely studied eukaryotic transposons, into naïve lines of Drosophila erecta . We monitored the invasion in 3 replicates for more than 50 generations by sequencing the genomic DNA (using short and long-reads), the small RNAs and the transcriptome at regular intervals. A piRNA based host defence was rapidly established in 2 replicates but not in the third, where P-element copy numbers kept increasing for over 50 generations. We found that siRNAs emerged prior to piRNAs, supporting the view that siRNAs initiate host defence. However, neither insertions in piRNA clusters nor the formation of siRNAs were sufficient to stop the P-element. Instead the activation of the ping-pong cycle was shown to be crucial. We introduce a novel model, the crank-up model, which emphasizes activation of the ping-pong cycle as a critical event in establishing host control over a TE. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
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Clément Goubert :verified:

RT @CedricFeschotte
Immensely proud of @sylviaandbu who defended her PhD today with typical brilliance, energy and joy! Congrats Dr. Chang!! Her work has transformed the way I think of transposons! 🥹🍾👏

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Clément Goubert :verified:

Can't be prouder of being French!
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RT @nocontextfre

twitter.com/nocontextfre/statu

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Clément Goubert :verified:

RT @huguesrc
Reconstruction of hundreds of reference ancestral genomes across the eukaryotic kingdom... all available in @genomicus!
nature.com/articles/s41559-022

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Clément Goubert :verified:

RT @justinfay
In 2018 I taught computational biology for the first time. Online resources (slides, etc) were very helpful and I vowed to post my material once it had settled into a more or less solidified state. I’ve now posted lectures and Python labs (ipynb) to github github.com/fayjustin/computati

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Clément Goubert :verified:

RT @deMendoza_Alex
A fully funded PhD position to study the evolution of DNA methylation readers in Eukaryotes in my lab @QMULepigenetics @QMUL in London. Tuition covered for Chinese 🇨🇳 or Mexican 🇲🇽 students. Thanks for sharing with potential candidates. Advert here: qmul.ac.uk/sbbs/postgraduate/p. .

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Clément Goubert :verified:

RT @hub_te
The next update: Tuesday January 31st (8AM PST // 11AM EST // 5PM CEST)

You can find the Zoom link in the -hub channel on TransposonsWorldwide Slack.

Join us to discuss developments of resources for TE Hub (tehub.org)

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Clément Goubert :verified:

RT @hquesneville
TEfinder 2.31 was released ! Check the new blaster, grouper, matcher, and duster. Speed improvment and bug fixes. Soon used by the package github.com/urgi-anagen/TE_find

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Clément Goubert :verified:

RT @JohannConfais
📢 Hey REPET users ! To improve the classification of your reference library there are new banks formatted for available on @INRAE_URGI website : urgi.versailles.inra.fr/Tools/. 🧵⬇️

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Clément Goubert :verified:

Whaou! Even better IRL!! Thanks again @BrancoLab @deMendoza_Alex @groza_cristian @xunchen85 @guilbourque

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Clément Goubert :verified:

It is also worth mentioning that is an amazing city, the food is the best in the country, and you are on the footsteps of the Alps, for endless outdoor activities!

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Clément Goubert :verified:

RT: Amazing in Lyon, France on the of adaptation of the Asian tiger mosquito Aedes albopictus. I know it's good, this is where I did my PhD! Great boss and atmosphere in a leading evolution lab (@LbbeLyon), excellent IT support and computational ressources.

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