Dimos Karamanlis @dimokaramanlis@qoto.org

It's taken 22 years, but public transport and archaeology meet in Thessaloniki this weekend with the opening of its new metro system, which will reduce traffic congestion by as many as 60,000 vehicles.
There are 13 'archaeostations' where ancient finds are displayed or are part of the infrastructure.

#Transport #Archaeology #Thessaloniki #Greece #PublicTransit

https://www.theguardian.com/world/2024/nov/30/a-blend-of-ancient-and-modern-inside-thessalonikis-new-3bn-metro-system?CMP=bsky_gu

Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Some unrest and abuse about this paper- Parts of the pre-print have been abused previously. What does it show?

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00438-4
1/10

Predicting the results of experiments is challenging, especially in fields like neuroscience. This recent study shows that fine-tuned LLMs, like BrainGPT, can predict neuroscience results more accurately than human experts on benchmarks. 🧪

https://www.nature.com/articles/s41562-024-02046-9.pdf

Boost this toot if you're planning on sticking around Mastodon & the Fediverse whether or not it's more popular than Bluesky.

New approach enhances neural implants for vision restoration.
https://elifesciences.org/articles/83424?utm_source=mastodon&utm_medium=social&utm_campaign=organic

my (personal) summary and then comments for this #JournalClub

any corrections, comments, additional questions are welcome, especially from the first author @jessetm

1/7
The main goal of this paper is to test if #VTEs (Vicarious Trial-and Error) and medial prefrontal cortex LFP relate to navigation behaviour parameters such as behavioural flexibility, performance and strategy use, during allocentric* navigation.

VTEs are a behaviour that rodents and humans do at choice points, looking alternatively at the different available options before choosing one (check video below). They have been studied mostly during response-based tasks (when the subjects have to learn a body-oriented response or sequence of responses to the reward). From that research, two possible roles for VTEs have been suggested: deliberation (weighing down the available options) or uncertainty (hesitation).

The current paper aims to test which is the most likely role of these two, by having a task involving a lot of deliberation and a lot of uncertainty (protocol explained below).
The main conclusion is that these two VTE types actually exist, which means VTEs should not just be interpreted as a marker of behavioural flexibility or deliberation. There is are also some interesting findings about different LFP rhythms in the medial prefrontal cortex being stronger during different types of behaviours (explained below).
(*) (allocentric = based on an external reference frame, like the Water maze task)

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cc: @Andrewpapale, @drdrowland, feel free to add your comments /questions anywhere you want!

Huge congrats to @karyna-mi.bsky.social (shes not on here) for her paper published today in Science! She found that the hippocampus is really important for a key strategy we use to make decisions called hidden state inference! 🧪 🧠 1/7 https://www.science.org/doi/10.1126/science.adq5874 #neuroscience

We wrote a review on analysis methods for large-scale neural recordings https://www.science.org/stoken/author-tokens/ST-2239/full @marius10p #neuroscience 🧠

Anything we missed? Reply w/ your fav method!

What does #neuroscience tell us about AI, and vice versa?

In this new PNAS paper, we find that real neurons' activation functions (f-I curves) share features with freq-used AI activation functions.

We measure many neurons w/ 2p holographic stim.

Work led by Paul LaFosse... 1/3 🧠📈 🧪

New programme by Dutch Research Council NWO: academic journals that wish to 'flip' from a subscription model to diamond open access (no fees for readers - no fees for authors) can apply for funding to transition: https://www.nwo.nl/en/news/funding-for-flipping-journals-to-diamond-open-access
#OpenAccessWeek

2/ More recent patch recording from Large Bistratified GCs show a consistent ON-OFF response to the L+M stimulus, quite distinct from that of the small BS GCs. These results also suggest that the input from L and M cone circuitry to the LBGCs might be distinct (Kim, Packer & Dacey, 2024). How?
https://www.pnas.org/doi/10.1073/pnas.2405138121

📢 #Rastermap paper out now, easily explore and visualize your neural recordings 🐭🐒🐟 and ANNs 🤖 https://nature.com/articles/s41593-024-01783-4. Updates from preprint include analyses of primate data and IBL task data.

Video tutorial: https://youtu.be/oQHq7yUWn2k #Neuroscience #MachineLearning