Dimos Karamanlis @dimokaramanlis@qoto.org

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??

#CellBiology #WTFology

https://www.biorxiv.org/content/10.64898/2025.12.12.693869v1

RE: https://mastodon.online/@neuroinformatics/115643481413121555

I'll be coordinating the "Animals in Motion" track of this summer school, returning to London in August 2026.

Apply to join us for some hands-on learning and collaboration on open-source tools for video behavioural analysis.

https://neuroinformatics.dev/open-software-summer-school

#neuroscience #python #behaviour #ethology

1/6 New preprint 🚀 How does the cortex learn to represent things and how they move without reconstructing sensory stimuli? We developed a circuit-centric recurrent predictive learning (RPL) model based on JEPAs.
🔗 https://doi.org/10.1101/2025.11.25.690220

Tokyo's "Extinct Media Museum" is quite nice, brings up many memories (phun intended..)

Reconstructing long-range axons from dense brain images is tough.

This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections.
https://elifesciences.org/articles/102840?utm_source=mastodon&utm_medium=social&utm_campaign=organic

If you are drafting figures for a scientific paper or presentation, remember that https://scidraw.io/ exists: a repository of free SVG cartoons for science.

#SciDraw is supported by the Sainsbury Wellcome Centre.

All content on SciDraw is shared under creative commons license (CC-BY) unless stated otherwise.

#inkscape #SVG #science

Online now: Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma https://www.cell.com/neuron/fulltext/S0896-6273(25)00552-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Online now: Coordination of distinct sources of excitatory inputs enhances motion selectivity in the mouse visual thalamus https://www.cell.com/neuron/fulltext/S0896-6273(25)00522-7?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Congratulations to the SWC Emerging Neuroscientists Seminar Series 2025/26 winners! 🎉

- Dimokratis Karamanlis, University of Geneva
- Raffaele Sarnataro & Peter S. Hasenhuetl, University of Oxford
- Saurabh Vyas, Columbia University
- @s_blumenstock, University of California San Diego

Join us for their talks, starting Nov 2025 📅

https://www.sainsburywellcome.org/web/seminar/swc-emerging-neuroscientists-seminar-series-202526-winners-announced

New preprint with @marcusghosh on how neural network architecture shapes function. We explored a wide range of architectures, and a family of tasks with components of navigation, decision making under uncertainty, multimodal integration and memory. Performance better explained by "computational traits" like sensitivity and memory, than by architectural features.

https://www.biorxiv.org/content/10.1101/2025.07.28.667142v1

#neuroscience #compneuro #computationalneuroscience

Quantifying the link between retinal performance and the optomotor response https://www.cell.com/current-biology/fulltext/S0960-9822(25)00873-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

We are hiring a postdoc. It's a broadly scoped position but I think it would be of interest to someone in #Neuromorphic or #SpikingNeuralNetworks. See ad below. Inquiries to Dan Akarca because I will be on holiday.

Note, the application deadline is very soon! (Unavoidable admin issues.)

https://www.imperial.ac.uk/jobs/search-jobs/description/index.php?jobId=24879&jobTitle=Research+Associate*+in+NeuroAI%2C+Neuromorphic+Systems%2C+Hardware-Software+Co-Design

Still doing #neuroscience.

Our #orbitofrontalcortex (#OFC) paper published in _Neuron_ today. (Also available in #biorxiv.)

Paul Cunningham, A. David Redish (2025) Opposing, multiplexed information in lateral and ventral orbitofrontal cortex guides sequential foraging decisions in rats Neuron.

https://www.cell.com/neuron/abstract/S0896-6273(25)00467-2

Key insights:

1. VO and LO are doing opposite things: LO is about immediate value, while VO is about opportunity costs.

2. OFC neurons are representing both task state (through which neurons are active) and value (as the total activity).

On Uniform Manifold Approximation and Projection (UMAP):

"Analytical properties of UMAP dimensionality reductions", Levernier and Rouault, 2023.
https://hal.science/hal-04046849/document

"Here we give analytical prediction for the UMAP projection of well defined datasets including pure noise, binary data and one-dimensional signal. For the latter, we uncover a phase transition in the lateral spreading of the projected points."

#UMAP

Dendritic architecture enables de novo computation of salient motion in the superior colliculus https://www.cell.com/current-biology/fulltext/S0960-9822(25)00820-6?rss=yes&utm_source=dlvr.it&utm_medium=mastodon