#aneuploidy

¡Un saludo al Fediverso! Esta es la cuenta de Bianor Biotech, una empresa de base tecnológica surgida de la Universidad de León, promovida por los profesores del Dpto. de Biología Molecular (Biología Celular) e INDEGSAL (https://fediscience.org/@indegsal) F. Martínez-Pastor y B. Martín-Fernández.
Trabajamos en biología de la reproducción y somos expertas en análisis espermáticos, especialmente análisis de la cromatina espermática para clínicas y empresas del sector ganadero y selección animal.
Actualmente, participamos en el proyecto H2020 NeoGiANT (https://neogiant.eu) investigando para reducir el uso de antibióticos en reproducción animal.
También estamos en Bluesky, LinkedIn y en https://bianorbiotech.es
#bianorbiotech #ReproSci #Science #ReproMed #Reproduction #BiologíaDeLaReproducción #sperm #spermatology #espermatozoide #SpermChromatin #DNAfragmentation #SDF #DSB #aneuploidy #SpermAnalysis #NeoGiANT #H2020 #AMR

Hypoxia regulates embryonic fitness in mosaic aneuploid embryos.

In his first preLight, Anchel De Jaime Soguero highlights work from Estefania Sanchez-Vasquez, Marianne E. Bronner & Magdalena Zernicka-Goetz. #preprint

Read his preLight + responses from the authors below

preLight https://prelights.biologists.com/highlights/hif1a-contributes-to-the-survival-of-aneuploid-and-mosaic-pre-implantation-embryos/

#biology #development #aneuploidy #embryo #hypoxia

Puzzle solved : A #CharitéBerlin team has found out how cells deal with extra chromosomes.

The previously unknown mechanism could help identify lines of attack in dealing with treatment-resistant #tumors & fungal #infections. The fundamental findings have now been published in #Nature.

https://www.charite.de/en/service/press_reports/artikel/detail/charite_study_in_nature_how_cells_deal_with_extra_chromosomes/

#CharitéPaper #CharitéBiomedicine #science #ScienceMastodon #research #cancer #aneuploidy

Eliminating extra chromosomes in cancer cells prevent tumor growth
https://www.sciencedaily.com/releases/2023/07/230706152349.htm
Date: July 6, 2023 | Source: Yale University
Summary: Cancer cells with extra chromosomes depend on those chromosomes for tumor growth, & eliminating them prevents the cells from forming tumors. The findings suggest that selectively targeting extra chromosomes may offer a new route for treating cancer

Comment: basic research still
...

#cancer #CancerCells #TumorGrowth #aneuploidy #CRISPR #p53 #TP53 #MDM4

#Aneuploidies are an ancestral feature of #trypanosomatids, and an ancient chromosome #duplication is maintained in extant species

João Luís Reis-Cunha et al
bioRxiv 2023.06.26.546280; doi: https://doi.org/10.1101/2023.06.26.546280

#leishmania #genome #genomics #aneuploidy

Effects of #Aneuploidy on cell behavior & function

Cause:
ROS
DNA replication
mitosis
mechanical confinement

Direct dosage + secondary Effect:
Redox, bioenergetic, proteostasis, Osmosis
Cancer, Aging

Dr Rong Li & Jin Zhu Nature Reviews MCB 2023
https://www.nature.com/articles/s41580-021-00436-9

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Any evidence on #Aneuploidy in cardiovascular biology?

From Abraham Aviv lab @ATHjournal 2001

Age-dependent aneuploidy & telomere length of the human vascular endothelium
https://www.atherosclerosis-journal.com/article/S0021-9150(01)00506-8/fulltext

Tetrasomy Chr6 Chr16
Loss ChrY

Aneuploidy in cardiovascular diseases?

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Mice with #SpindleAssemblyCheckpoint protein BubR1 deficiency have a spectrum of vascular defects

Vascular BubR1 1/3

Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1

Dr. Jan van Deursen lab @StrokeAHA_ASA 2007
https://www.ahajournals.org/doi/10.1161/01.STR.0000257967.86132.01

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Vascular BubR1 2/3

BubR1 Insufficiency Inhibits #NeointimalHyperplasia Through Impaired Vascular #SmoothMuscleCell Proliferation in Mice

Dr. Takuya Matsumoto lab @atvbahajournals 2014
https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.304737
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Vascular BubR1 3/3

BubR1 insufficiency impairs #Angiogenesis in aging and in experimental critical limb ischemic mice

Dr. Takuya Matsumoto lab @JVascSurg 2018
https://www.jvascsurg.org/article/S0741-5214(17)32041-4/fulltext

How do #yeast adapt to #chromatinization with human #histones and subsequent #aneuploidy?

Jeff Boeke, @maxhaase et al from NYU Langone find #ploidy stabilization by DASH/Dam1 complex mutants that weaken #kinetochore-#microtubule attachment strength

https://www.embopress.org/doi/10.15252/embj.2022112600

Enjoying this paper from the Sheltzer lab - it reads a bit like a group of biologists playing detective. They start with a theory that #aneuploidy is necessary for the malignancy of some cancer lines, and then trace this all the way to showing some very tight links to MDM4. They even propose a therapeutic using differential sensitivity between disomic and trisomic cells.

https://www.biorxiv.org/content/10.1101/2023.01.09.523344v1

At #SMBE #GS6 - good poster session, including models of #aneuploidy stress responses in yeast that link to the architecture of #PPI #networks (relative rate of direct vs indirect PPI connections)