#angiogenesis
These are public posts tagged with #angiogenesis. You can interact with them if you have an account anywhere in the fediverse.
Just Published
Melatonin and Cancer: New Insights
https://link.springer.com/chapter/10.1007/16833_2024_231
#Cancer #CancerResearch #CancerTherapy #Angiogenesis #Apoptosis
Large Cities And Cancer Share An Unexpected Similarity
https://www.sciencealert.com/large-cities-and-cancer-share-an-unexpected-similarity #cities #cancer #spread #malignant #trains #angiogenesis
City planners aren't doctors.
www.sciencealert.comHow cells stay sensitive to environmental cues and control the fate of cells during the formation of new blood vessels. #Angiogenesis https://elifesciences.org/digests/89262/growing-new-blood-vessels?utm_source=mastodon&utm_medium=social&utm_campaign=organic
@persagen@mastodon.socialDietary antioxidant supplements could help cancers grow
https://studyfinds.org/dietary-supplements-help-tumors
Discussion: https://news.ycombinator.com/item?id=37349870
* vit. A, C, selenium, zinc can stimulate growth of blood vessels in cancer when in excess
* surprised researchers: antioxidants believed protective
Antioxidants stimulate BACH1-dependent tumor angiogenesis
https://www.jci.org/articles/view/169671
COMMENT: not surprising; see, e.g.: https://pubmed.ncbi.nlm.nih.gov/?term=salganik+ri+%5BAUTH%5D+unc
#antioxidants #OxidativeStress #ROS #vitamins #apoptosis #angiogenesis #cancer #BACH1
While scientists state that natural levels of antioxidants…
studyfinds.orgProteolytic activation of #angiomotin by #DDI2 promotes #angiogenesis
Cleavage of the scaffold protein AMOT promotes vascular expansion in a manner modulated by membrane localization, poly-(ADP)ribosylation, and ubiquitination
https://www.embopress.org/doi/full/10.15252/embj.2022112900
Check out this interesting article!
"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"
Check out this interesting article!
"Negative-Pressure Wound Therapy: What We Know and What We Need to Know"
Big Congrats 
to Rui Li & collaborators from the lab of Stefan Offermanns at @mpi_hlr
for this great #NatureComms paper showing that FAT1 controls YAP/TAZ degradation via the E3 ligase MIB2 during #angiogenesis.
Happy of my small contribution!
https://doi.org/10.1038/s41467-023-37671-x
Effects of #Aneuploidy on cell behavior & function
Cause:
ROS
DNA replication
mitosis
mechanical confinement
Direct dosage + secondary Effect:
Redox, bioenergetic, proteostasis, Osmosis
Cancer, Aging
Dr Rong Li & Jin Zhu Nature Reviews MCB 2023
https://www.nature.com/articles/s41580-021-00436-9
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Any evidence on #Aneuploidy in cardiovascular biology?
From Abraham Aviv lab @ATHjournal 2001
Age-dependent aneuploidy & telomere length of the human vascular endothelium
https://www.atherosclerosis-journal.com/article/S0021-9150(01)00506-8/fulltext
Tetrasomy Chr6 Chr16
Loss ChrY
Aneuploidy in cardiovascular diseases?
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Mice with #SpindleAssemblyCheckpoint protein BubR1 deficiency have a spectrum of vascular defects
Vascular BubR1 1/3
Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1
Dr. Jan van Deursen lab @StrokeAHA_ASA 2007
https://www.ahajournals.org/doi/10.1161/01.STR.0000257967.86132.01
=======
Vascular BubR1 2/3
BubR1 Insufficiency Inhibits #NeointimalHyperplasia Through Impaired Vascular #SmoothMuscleCell Proliferation in Mice
Dr. Takuya Matsumoto lab @atvbahajournals 2014
https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.304737
====
Vascular BubR1 3/3
BubR1 insufficiency impairs #Angiogenesis in aging and in experimental critical limb ischemic mice
Dr. Takuya Matsumoto lab @JVascSurg 2018
https://www.jvascsurg.org/article/S0741-5214(17)32041-4/fulltext
Coronary #EndothelialCells want WT1 as well
A Research Highlight showcasing new work from Marina Ramiro-Pareta, Ofelia Martínez-Estrada & colleagues
Read the full #OpenAccess Research Article, 'Endothelial deletion of #Wt1 disrupts coronary #angiogenesis and #myocardium development', here:
https://journals.biologists.com/dev/article/150/6/dev201147/297331/Endothelial-deletion-of-Wt1-disrupts-coronary
We interviewed the authors, Marina Ramiro-Pareta & Ofelia Martínez-Estrada for our 'The people behind the papers' series:
https://journals.biologists.com/dev/article/150/6/dev201740/297330/The-people-behind-the-papers-Marina-Ramiro-Pareta
Li-Juan Duan et al. show that #Tailless (TLX) and #hypoxia inducible factor-2α (HIF2α) cooperate to sustain proangiogenic states of retinal #astrocytes in neonatal mice:
#Retina #Angiogenesis #OxygenSensing #Science #BiologyOpen #Biology #AcademicMastodon
Just Published!
"The Implication of miRNA Signature in the Characteristic Features and Diagnosis of Lung Cancer"
https://link.springer.com/chapter/10.1007/16833_2023_130
#Cancer #CancerResearch #Angiogenesis #Diagnosis #Biomarkers
#Monocyte deposits VEGF/CXCL12-containing #Migrasome to stimulate CAM #Angiogenesis, as well as reinforce monocyte recruitment
Wonder if this fascinating cascade is also functional in tissue regeneration?
Dr. Li Yu lab Nature Cell Bio 2022
https://www.nature.com/articles/s41556-022-01026-3
Getting ready for the weekend? Time to hit the gym!
discoveries @ETH about how muscles grow could lead to regenerative therapies for conditions like #diabetes & arterial occlusions.
https://bit.ly/3Xka8oD
#angiogenesis #homeostasis
@CORDIS_EU @debocklab @ETH_en
: https://n.respublicae.eu/ERC_Research/status/1616707209936908289
What an eye-opening review!
Metabolites as signalling molecules
Absolutely a must-read for biology researchers
Dr. Steven Andrew Baker & Jared Rutter Nature Reviews Molecular Cell Biology 2023
https://www.nature.com/articles/s41580-022-00572-w
For the #Angiogenesis lovers, read this great #AngioMetabolite story
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Mφ Polarization
EC in hypoxic muscle is a major resource of Lactate!
Dr. Katrien de Bock @cell_metabolism
2020
https://www.sciencedirect.com/science/article/pii/S1550413120302436
So hard to keep updated with the literature, even review
Perhaps need to ask #ChatGPT to how to strategize my reading......
In this Future Leader #Review, Nidhi Yadunandanan Nair and colleagues discuss how endothelial #actin structures and actin-mediated force generation coordinate the multi-step angiogenic process:
Find out more about how to propose your own Future Leader Review here:
https://journals.biologists.com/bio/pages/reviews
#Angiogenesis #Vasculature #Endothelium #Science #BiologyOpen #Biology #AcademicMastodon
Stabilizing FOXF1 to treat #AlveolarCapillaryDysplasia
Chemical screening->TanFe
Ubiquitination of FOXF1 viabinding to #E3Ligase HECTD1/SHPRH/NEURL1B etc->
Restoring Lung #Angiogenesis of Foxf1+/-
Dr. Vladimir Kalinichenko lab Am J Respir Crit Care Med 2022
https://www.atsjournals.org/doi/10.1164/rccm.202207-1332OC
How FOXF1 impacts #EndothelialCell #Angiogenesis?
As a transcription factor for S1PR1 & VE-Cad
An excellent story from Dr. Vladimir Kalinichenko lab @scisignal 2016
FOXF1 maintains endothelial barrier function and prevents edema after lung injury
https://www.science.org/doi/10.1126/scisignal.aad1899
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, due to FOXF1 heterozygous mutation, has very complex Lung & ex-Lung vascular phenotypes
A few reads
https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-020-00972-6
https://www.nature.com/articles/jp201494
https://www.nature.com/articles/ejhg2012171
https://www.jpeds.com/article/S0022-3476(04)00647-X/fulltext
Just Published!
"The Effects of Angiotensin-Converting Enzyme Inhibitors on Metastasis-Associated Myeloid Cells"
https://link.springer.com/chapter/10.1007/16833_2022_91
#Angiogenesis #Metastases #Immunotherapy #Cancer #CancerResearch
ATF3+ lung capillary #EndothelialCell proliferates & promotes #AlveolarRegeneration post H1N1 injury #Flu
ATF3 KO EC 14 dpi->Proliferation
Apoptosis
Altered Angiogcrine toAT1+AT2 epithelial cells
Dr. Edward E. Morrisey lab bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.10.14.512212v1.full
Reminiscent of the really cool work from Dr. Katrien De Bock @cell_metabolism 2021
#SkeletalMuscle ATF3/4+ Capillary #EndothelialCell, preferably surrounding oxidative myofibers, as a major cellular origin of Exercise-induced #Angiogenesis
https://www.sciencedirect.com/science/article/pii/S1550413121003314
