These are public posts tagged with #aorticaneurysm. You can interact with them if you have an account anywhere in the fediverse.
CRISPR-activated Oct4 as #GeneTherapy for #Progeria (LmnaC698G) & natural aged
#HutchinsonGilfordProgeriaSyndrome
Polyethylenimine-cationic gold nanoparticle iv.
Do we need an aortotropic vector for #AorticAneurysm?
Dr. Jongpil Kim lab @AgingCell 2023
https://onlinelibrary.wiley.com/doi/10.1111/acel.13825
Through Oct4 expression is only transiently activated for 2 weeks in 50% aortic SMCs (by day 5 delivery) in progeria mice, but with an amazing long-lasting benefits on SMC vitality, arterial stiffness, progerin, multi-organ ( kidney, spleen, muscle, lung, and skin) senescence transcriptional profile, lifespan w/o apparent dysplasia
BRD4 (acetyl lysine reader)-NIPBL (cohesin loading ) complex is critical to #NeuralCrest differentiation into #SmoothMuscleCell
BRD4 depletion->#GenomeFolding+loop extrusion
BRD4 in #AorticAneurysm?
Dr. Rajan Jain lab Nature Genet 2021
https://www.nature.com/articles/s41588-021-00934-8
Thoracic #AorticDissection (type A+B) in Nova Scotia, Canada2005-2015
382 scheduled thoracic #AorticAneurysm repair
294vs 88
345 dissection events
212vs 133
4.4 vs 2.4 per 10,000 person-years
Dr. Claudia Cote lab #CJCOpen 2022
https://www.cjcopen.ca/article/S2589-790X(22)00176-7/fulltext
Decoupling #TGFβ1 with phospho-SMAD2 (S457) & phospho-SMAD3 (S423/425) in ascending #AorticAneurysm with #BicuspidAorticValve or #UnicuspidAorticValve
How about TGFβ2/3?
As a comparison, in #TricuspidAorticValve aorta, diameter and elastin break correlate well with increased TGFβ1 level or p-SMAD2/3 levels
Dr. Brittany Balint & Hans-Joachim Schäfers lab, Sci Rep 2022
https://www.nature.com/articles/s41598-022-19335-w
Phospholipase Cε #Aortopathy
Plce1 KO are susceptible to ANGII-induced ascending #AorticAneurysm+Dissection
Role of adventitial myofibroblast cytokines?
Dr. Alan Smrcka, Santhi Ganesh, Markus Bitzer labs AJP Heart Circ 2022
https://journals.physiology.org/doi/abs/10.1152/ajpheart.00262.2022
Referenced link: https://medicalxpress.com/news/2022-10-large-thoracic-aortic-aneurysm-guidelines.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2022-10-large-thoracic-aortic-aneurysm-guidelines.html
Originally posted by Phys.org / @physorg_com@twitter.com: https://twitter.com/medical_xpress/status/1577675001960038400#m
RT by @physorg_com: Large study of thoracic #aorticaneurysm backs guidelines @JAMACardio https://medicalxpress.com/news/2022-10-large-thoracic-aortic-aneurysm-guidelines.html
A large, new Kaiser Permanente study provides high-quality…
medicalxpress.com