#CancerImmunity

Cholesterol & anti tumor T cell immunity:

"We analyze the cholesterol atlas in the tumor microenvironment and find that intratumoral T cells have cholesterol deficiency, while immunosuppressive myeloid cells and tumor cells display cholesterol abundance. Low cholesterol levels inhibit T cell proliferation and cause autophagy-mediated apoptosis, particularly for cytotoxic T cells"

#Immunology #immunotherapy #immunooncology #CancerImmunity

https://www.sciencedirect.com/science/article/abs/pii/S1535610823001423?via%3Dihub

STING maintains cells with metastatic potential in a dormant state in a mouse LUAD model.
#Immunology #TumorImmunology #CancerImmunity

https://www.nature.com/articles/s41586-023-05880-5

'All that is (at least to me) a rather startling variety of bacteria in such tissues, and I think the authors probably felt so, too. Further work on protein markers of inflammation, immune function, and tumor progression strongly suggested that these bacteria were mostly found in highly immunosuppressed microniche environments. It appears, for example, that T cells are largely excluded from regions with high bacterial colonization.'
- Derek Lowe

#Immunology #CancerImmunity #Microbiology

https://www.science.org/content/blog-post/bacteria-and-cancer-it-s-not-random

#Immunology #CancerImmunity #Immunotherapy

"The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial transcriptomics to examine the nature of B cell responses within TLS in renal cell carcinoma (RCC)."
Meylan et al (#Immunity, fm Feb 2022)

https://www.cell.com/immunity/fulltext/S1074-7613(22)00081-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761322000814%3Fshowall%3Dtrue