These are public posts tagged with #EndothelialBarrier. You can interact with them if you have an account anywhere in the fediverse.
#LaminarShear pushes VE-PTP (How?) to downstream pole of #EndothelialCell, followed by endocytosis->
p-Tie2
Potentially explain how #DisturbedFlow#VascularPermeability & #Atherosclerosis
Inhibition of VE-PTP by AKB-9785 fortifies #EndothelialBarrier & reduces Atheromas at atheroprone regions (aortic arch inner curvature, arch+intercostal bifurcations)
Nice comparison of anti-leakage strategies
VE-PTP inhibition
Angpt1 activation of Tie2
Angpt2 inhibition
Dr. Donald McDonald & Dietmar Vestweber labs EMBO Mol Med 2023
https://www.embopress.org/doi/