#fibrosis

https://www.europesays.com/uk/44507/ Antimalarial drug enhances effect of aminoglycosides in genetic disorders #CysticFibrosis #Drugs #DuchenneMuscularDystrophy #Electron #Fibrosis #Genetic #Genetics #Mefloquine #Microscope #MuscularDystrophy #Research #Ribosome #Science #UK #UnitedKingdom

CRISPR technologies paving the way for advances in regenerative medicine https://www.byteseu.com/825509/ #Cas9 #Cell #CRISPR #CysticFibrosis #Fibrosis #GENE #Genes #Genetic #Medicine #OsteogenesisImperfecta #ProgenitorCells #Research #SickleCellDisease #StemCells #Technology

Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues"

#biomaterials #tissueengineering #regenerativemedicine #biology #implants #inflammation #immunomodulation #fibrosis #medicine #healthcare #engineering #magnesium #science

@inkican

"The drug, a manufactured antibody that attacks interleukin-11, is being trialled in patients with lung fibrosis. This is where the lungs become scarred, making it harder to breathe."

Hope the trial is successful.

#fibrosis #PulmonaryFibrosis #lungs #IL11

@ScienceScholar

Really exciting. I wish I could access the research article.

I wonder if the anti-fibrotic alkaloids are dopamine agonists.*

* https://doi.org/10.1126/scitranslmed.aau6296

#NaturalProducts #fibrosis

Improved #pulmonary #function and #exercise #tolerance despite persistent pulmonary #fibrosis over 1 year after severe #COVID19 infection http://thorax.bmj.com/cgi/content/short/79/5/472?rss=1

Despite a high prevalence of fibrotic patterns (64%), pulmonary function, #grip strength, 6 min #walk distance and frailty normalised. Overall, #dyspnoea, #cough and #exhaustion did not improve and were not correlated with pulmonary function or radiographic fibrosis at 15 months, suggesting non-respiratory aetiologies.

#Cystic #fibrosis is a #genetic disease that causes serious and sometimes fatal #respiratory and #digestive disorders. A new treatment, available since 2020, improves lung function and quality of life. However, it does not always eradicate the #bacteria responsible for respiratory infections.
#Biomolecular #Genetics #CF #sflorg
https://www.sflorg.com/2024/04/bmol04042402.html

#Cystic #fibrosis is the most common, life-limiting genetic condition in Australia. It affects the #lungs, #digestive system, and reproductive system, producing excess mucus, infections, and blockages.
#Pharmaceutical #Nanotechnology #Medical #sflorg
https://www.sflorg.com/2024/03/phar03292401.html

PhD position in ERC funded project on myeloproliferative neoplasms

RWTH Aachen

Come and join us as a #PhD student to dissect molecular and cellular mechanisms in bone marrow #fibrosis in #MPN in an ERC funded research project.

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-27778-phd-position-in-erc-funded-project-on-myeloproliferative-ne...
https://jobrxiv.org/job/rwth-aachen-27778-phd-position-in-erc-funded-project-on-myeloproliferative-neoplasms/?feed_id=72666

An #m6A-independent function of #YTHDC1: its expression delays cellular #senescence and pulmonary #fibrosis by interacting with #TopBP1 to activate ATR
https://www.embopress.org/doi/full/10.15252/embj.2023113675

Serum infrared spectral profile is predictive of the degree of hepatic fibrosis in chronic hepatitis C patients.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Volume 305, 15 January 2024, 123433
https://doi.org/10.1016/j.saa.2023.123433
#infrared #liver #fibrosis

Hi #ScienceMastodon! Next up for JCS Research Highlights we feature work on #mechanosignaling in liver #fibrosis from Nour Hijazi, Zengdun Shi and Don Rockey at the Medical University of South Carolina. They identify the focal-adhesion associated protein paxillin as an important signaling node for communicating extracellular forces in hepatic stellate cells.

Paxillin links the ECM to fibrogenic signalling in liver fibrosis
https://journals.biologists.com/jcs/article/136/18/e136_e1803/330713/Paxillin-links-the-ECM-to-fibrogenic-signalling-in

Researchers Discover Surprising Side Effect of Common Diabetes Drug
Researchers found that Metformin, a common diabetes drug, can prevent muscle atrophy and fibrosis, potentially aiding in faster recovery from injury in the elderly. The drug targets senescent cells, which affect muscle function, and its benefits were observed in a study with older adults during periods of muscle disuse and recovery.
https://scitechdaily.com/researchers-discover-surprising-side-effect-of-common-diabetes-drug/ #Aging #Diabetes #Drugs #Muscle #metformin #atrophy #fibrosis

We commonly use #nitrofurantoin to treat #UTI and even sometimes as prophylaxis for recurrent infections.

Super safe #antibiotic but a reminder that rarely it can cause serious complications #lung #fibrosis
@infectiousdiseases @microbiology #IDMastodon #MedMastodon #medicine

Chronic Nitrofurantoin-Induced Lung Injury

https://www.nejm.org/doi/full/10.1056/NEJMicm2214831

People with weakened #immune systems are at constant risk of infection. #Pseudomonas #aeruginosa, a common #environmental #bacterium, can colonize different body parts, such as the #lungs, leading to persistent, chronic infections that can last a lifetime – a common occurrence in people with #cystic #fibrosis.
#Biology #Medical #sflorg
https://www.sflorg.com/2023/06/bio06142302.html

Postdoctoral Researcher (all genders) Fibrosis and Wound Healing @BioMed_X

The BioMed X Institute is establishing a new, fully funded research group at its new XSeed Labs incubator.

https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-fibrosis-and-wound-healing/?feed_id=44478

#ScienceJobs #job #fibrosis #woundhealin...
https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-fibrosis-and-wound-healing/?feed_id=44478

https://www.science.org/doi/10.1126/sciadv.adf2331

"The ectopic activation of ERK in scar-prone injuries induced a pro-regenerative response, including cell proliferation, extracellular matrix remodeling, and hair follicle neogenesis. Our data detail an important distinction in ERK activity between regenerating and poorly regenerating adult mammals and open avenues to redirect fibrotic repair toward regenerative healing"

#healing #fibrosis #scarTissue #enzyme #kinase #phosphorylation #mammalianBiology #mammal #scar

Postdoctoral Researcher (all genders) Fibrosis and Wound Healing @BioMed_X

The BioMed X Institute is establishing a new, fully funded research group at its new XSeed Labs incubator.

https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-fibrosis-and-wound-healing/?feed_id=43758

#ScienceJobs #job #fibrosis #woundhealin...
https://jobrxiv.org/job/biomed-x-institute-27778-postdoctoral-researcher-all-genders-fibrosis-and-wound-healing/?feed_id=43758

Referenced link: https://medicalxpress.com/news/2023-04-reveals-mechanism-circadian-clock-molecule.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-04-reveals-mechanism-circadian-clock-molecule.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1647995608689528833#m

RT by @physorg_com: Study reveals mechanism by which a circadian clock molecule leads to #lung #fibrosis @NatureComms https://www.nature.com/articles/s41467-023-36896-0 https://medicalxpress.com/news/2023-04-reveals-mechanism-circadian-clock-molecule.html

New Findings Suggest a Potential Treatment for Fibrosis
According to a study published in Cell Death & Disease, scientists at Nagoya University in Japan have discovered two enzymes that play a role in macrophage polarization, a key factor affecting fibrosis. The findings of the study suggest a promising treatment possibility for human patients.
https://scitechdaily.com/new-findings-suggest-a-potential-treatment-for-fibrosis/ #fibrosis #enzyme