#GenomeFolding
These are public posts tagged with #GenomeFolding. You can interact with them if you have an account anywhere in the fediverse.
Out today in Nature Methods: our manuscript outlining improvements we've made to Genome Architecture Mapping (GAM) and comparisons between GAM and Hi-C.TLDR: We made GAM much cheaper, show that it performs better than Hi-C at detecting complex interactions and identify a class of CTCF-enhancer interactions that are poorly detected by Hi-C. Paper at https://doi.org/10.1038/s41592-023-01903-1 and the story behind the work at https://protocolsmethods.springernature.com/posts/appreciating-the-complexity-of-dna-folding #genomics #GenomeFolding #epigenetics #paper #ctcf #HiC
BRD4 (acetyl lysine reader)-NIPBL (cohesin loading ) complex is critical to #NeuralCrest differentiation into #SmoothMuscleCell
BRD4 depletion->
#GenomeFolding+loop extrusion
BRD4 in #AorticAneurysm?
Dr. Rajan Jain lab Nature Genet 2021
https://www.nature.com/articles/s41588-021-00934-8
Re-posting an #introduction after moving server:
My research group at the Wellcome Centre for Human Genetics in Oxford uses #SingleCell techniques and Genome Architecture Mapping to study #epigenetics #Chromatin and #GenomeFolding in rare #NeurodevelopmentalDisorders.
I (He/Him) love to be outside #Hiking or #Cycling and I’m a big fan of #FlightFree travel. Interested in #Equity issues in STEM, trying to read and educate myself to be a better ally.
Toot at me with your #Andor theories!
About time for an #introduction. My research group at the Wellcome Centre for Human Genetics in Oxford uses #SingleCell techniques and Genome Architecture Mapping to study #epigenetics #Chromatin and #GenomeFolding in rare #NeurodevelopmentalDisorders.
I (He/Him) love to be outside #Hiking or #Cycling and I’m a big fan of #FlightFree travel. Interested in #Equity issues in STEM, trying to read and educate myself to be a better ally.
Toot at me with your #Andor theories!