#GlucoseIntolerance

Pancreatic Rab11a/Rab11b dKO->
Aberrant polarized transport of apical/basolateral proteins->
AMIS supernumerary->
Defects in ductal #Lumenogenesis; Acinar morphogenesis; Pancreatic cell lineage dysregulation

Highly intriguing, PancRab11KO->Sox9+ bipotent progenitor & #Islet mass-> #GlucoseIntolerance in suvived adult

Lumenized epithelial paracrine or endocrine-autonomous defect?

No baseline change in fast glucose. Insulin/glucagon? Adult islet histology-Amyloid degeneration?

The branched, lumenized pancreatic duct is fragmented into disconnected Microlumens + enlarged Cyst in PancRab11KO

Can't help but think Rab35 in anisotropic Lumenogenesis of liver #BileCanaliculi

Is there a primary hydro-osmotic defect here?

Still, what happens to pancreatic vascular morphogenesis in Panc-Rab11 KO?(Surely, epithelia & endothelia are coupled)

More importantly, now it's the magic timing if you also want to have such amazing stories

Cleaver lab is recruiting TWO postdocs

Dr. Ondine Cleaver lab @ondinecleaver2022 bioXRiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.17.516976v1