#Helicobacter

A study reveals #molecular details about the #gastric #pathogen #Helicobacter pylori's ability to bind to an inflamed stomach and how this is controlled by the stomach's pH. Increased understanding of how H. pylori #bacteria can cause a persistent lifelong infection
#Microbiology #Biochemistry #Biology #sflorg
https://www.sflorg.com/2024/03/mcb03202401.html

#Evolutionary 'U-turn' may mitigate #antibiotic #resistance, study finds.

#horizontal_gene_transfer #Helicobacter

https://phys.org/news/2024-01-evolutionary-mitigate-antibiotic-resistance.html

'The colonization of our stomachs by #Helicobacter pylori is believed to predate the oldest splits between extant human populations. We identify a Hardy ecospecies of H. pylori associated with indigenous groups, isolated from people in Siberia, Canada, and USA.'

#Preprint #EvolutionaryBiology

https://www.biorxiv.org/content/10.1101/2023.04.28.538659v3

"We have established a #Helicobacter-induced accelerated disease progression mouse model, which involves infecting mice deficient in the myeloid differentiation primary response 88 gene (Myd88-/-) with H. felis. Using this model, we report here that that progression of H. felis-induced inflammation to high-grade dysplasia was associated with activation of type I interferon (IFN-I) signaling pathway and upregulation of related downstream target genes, IFN-stimulated genes (ISGs)." #Preprint

https://www.biorxiv.org/content/10.1101/2023.06.04.543598v1?med=mas

'Flagella-driven motility is essential for the entry of H. pylori into the mucus layer and for maintaining a swimming reservoir in the mucus (Fig. 3). H. pylori has a unipolar bundle of rotating sheathed flagella, with filaments composed of two flagellin proteins that evade activating the innate immune system via TLR5 due to specific adaptation of their amino acid sequences'

#Helicobacter #InnateImmunity #HostPathogen

https://www.nature.com/articles/s41572-023-00431-8

Fantastic to see this paper out from one of our former PhD students.

Genomic diversity of Helicobacter pylori populations from different regions of the human #stomach https://www.tandfonline.com/doi/full/10.1080/19490976.2022.2152306

Dan did a huge amount of cultivation and metagenomic work to look at #Helicobacterpylori diversity in the human corpus and antrum. By looking at isolates from biopsy samples, Dan found each patient is initially infected with a single strain of #Helicobacter which then diversifies.

#microbiome #microbiota