#HighThroughput

Four years after publishing my work on machine-driven parameter screen of biochemical reactions, it still has zero citations. That makes me sad; I am really proud of this work. So I asked ChatGPT to suggest me hashtags, for another chance to reach readers. https://academic.oup.com/nar/article/48/7/e37/5728495 #MolecularBiology #BiochemicalReactions #ReverseTranscription #RNASequencing #LabAutomation #GeneExpression #SingleCellAnalysis #HighThroughput #AIinScience #ComputationalBiology #BiotechInnovation #DataDrivenResearch

Impressive new work by Moravec et al. in Nature Biotechnology, sadly not open source. "... a #HighThroughput personalized #TCR discovery pipeline ..." with which they "...identified dozens of CD4+ and CD8+ T-cell-derived TCRs with potent tumor reactivity, including TCRs that recognized patient-specific #neoantigens."

https://www.nature.com/articles/s41587-024-02210-6

#cancer #tumour #Tcells
#science

The ultra-rare #lysosomaldisease #MultipleSulfataseDeficiency (MSD) is a progressive currently incurable neurodegenerative disorder.
Here a #HighThroughput #DrugScreening allows identification of retinoids #tazarotene and #bexarotene as active therapeutic agents for MSD in-vitro.

By L. Schlotawa, J. Gärtner & colleagues at Uni Goettingen

#openaccess: https://doi.org/10.15252/emmm.202114837

Do you like #highcontentimaging, #bioimageanalysis, #highthroughput #screening, and/or do you just plain love learning biology from images? If so, have you saved October 31st to November 2nd to come to Boston for the #SBI2 #SocietyOfBiomolecularImagingAndInformatics Annual Meeting? I personally promise to bring the Halloween candy, and our speakers and vendors will bring the amazing science!

Our first issue of 2023 is out!

Review on #HighThroughput #MassSpec in #DrugDiscovery, commentaries, News & Views, and research articles on #DepressiveDisorders, #AlzheimersDisease, #RetinalAngiogenesis, #leukemia, #BreastCancer, #MultiDrugResistance, and #CReactiveProtein!

Very nice cover that highlights the article from Lu K, Guo X, Liu Y & colleagues on depressive disorders

Issue fully #openaccess: https://www.embopress.org/toc/17574684/2023/15/1

A Flexible and Efficient #Microfluidics #Platform for the Characterization and Isolation of Novel #Bacteriophages | Applied and Environmental Microbiology

#phage #phages #highthroughput
https://journals.asm.org/doi/10.1128/aem.01596-22

Exciting research opportunity on everything #phages at @LBNLBioSci

#phage #postdoc #highthroughput #genetics #synbio #evolution

https://lbl.referrals.selectminds.com/jobs/postdoctoral-fellow-enigma-project-5299

#Introduction:

Hello #ScienceMastodon.

My name is Verena Kohler and I am a #FirstGen #scientist, currently working as independent senior #postdoc at #UniGraz in Austria.

I am interested, how age influences #proteostasis, the balance between protein production, folding and degradation, and how #ageing affects cellular #communication routes.
For that, I am using my favourite #ModelOrganism, the baker’s #yeast, a lot of #FluorescenceMicroscopy and #HighThroughput screens.

Let’s talk #science !

A #high-throughput cytotoxicity screening #platform reveals agr-independent mutations in bacteraemia-associated #Staphylococcus aureus that promote intracellular #persistence | bioRxiv

https://www.biorxiv.org/content/10.1101/2022.12.11.519971v1

#geneticscreening #genetics #highthroughput

Massively-parallel Microbial mRNA Sequencing (M3-Seq) reveals heterogeneous behaviors in #bacteria at single-cell resolution | bioRxiv

“show that M3-Seq can profile hundreds of thousands of bacterial cells from different species under a range of conditions in single experiments”

https://www.biorxiv.org/content/10.1101/2022.09.21.508688v2

#rnaseq #journalclub #highthroughput #bacteria #microbiome #microbialcommunities

#High-throughput retrieval of target sequences from complex clone #libraries using #CRISPRi

https://www.nature.com/articles/s41587-022-01531-8

#crispr #crispri #functional #metagenomics #highthroughput

#Introduction: I am a staff scientist & principal investigator at
Lawrence Berkeley National Lab @LBNLBioSci & Sci #Cofounder @ FelixBiotech

My lab develops #highthroughput techs & tools study #phages & #bacteria #phageengineering #phageresistance I am passionate about #phagefoundry

#synbio #genomics #barcodes #genetics #microbiome #MicrobialGenomics #phage #AMR #phagetherapy #antibiotics #microbiology #tailocin #crispr #india #entrepreneur #biosecurity

A short account of a recent paper led by Steve Butler on the development of a europium (III) radiometric sensor for PAP/PAPS. Of interest to #GlycoTime #Sulfation #Sulfotransferase #HighThroughput https://ferniglab.wordpress.com/2022/11/08/real-time-sulfotransferase-assay/