#HyaluronicAcid

.. We discuss our interpretation: that we may be seeing (unexpected) regions of high-MW HA that play a role in HA recognition and binding by HA-interacting proteins. At the same time, these (#NMR) methods should be important tools for studying the molecular and atomic features of the wide variety of #hyaluronicacid #polysaccharide based #biomaterials and hydrogels that are in use in the pharmaceutical industry and #biomedicalengineering.
Anyway, check out the paper: https://doi.org/10.1021/acsami.4c08428

Amazing creatures! [see Wikipedia intro]

Naked mole rat longevity gene extends lifespan of mice
https://www.sciencedaily.com/releases/2023/08/230823165402.htm

* ageing multifactorial: genetics, epigenetics, environment, metabolism
* HMM-HA: hyaluronic acid
* transcriptome signature nmrHas2 mice shifted towards longer-lived species

Incr. hyaluronan by naked mole-rat Has2 improves healthspan in mice
https://www.nature.com/articles/s41586-023-06463-0
https://www.biorxiv.org/content/10.1101/2023.05.04.539405v1

Naked mole-rat: https://en.wikipedia.org/wiki/Naked_mole-rat

#NakedMoleRat #ageing #HyaluronicAcid

In browsing for lube I found some "for women" with hyaluronic acid in and I'm like, wait. That's the goo I put on my face! Is this a gimmick? So I looked into it and lo and behold, a I found a meta-analysis concluding that #HyaluronicAcid helps with vaginal itching and dryness. I've had postnatal problems with irritation, so the face goo is now going on my #vulva. Not sure yet if it helps, but it feels nice!
https://pubmed.ncbi.nlm.nih.gov/33759670/#:~:text=Hyaluronic%20acid%20was%20generally%20found,%2C%20atrophy%2C%20vaginal%20pH)

#sex #vagina #skincare #science @vagina_museum

A highly intriguing #Hyperglycemia-#HyaluronicAcid-CD44-Survivin cascade dictates β-islet survival

4-methylumbelliferone, an HA biosynthesis inhibitor, protects diabetic(db/db; STZ 40 mg) from hyperglycemia

Dr. Paul Bollyky lab BioRxiv 2023
https://www.biorxiv.org/content/10.1101/2023.02.28.530522v1.full

Want to know about this drug 4-methylumbelliferone/#Hymecromone?

4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer

Front Immunol 2015
https://www.frontiersin.org/articles/10.3389/fimmu.2015.00123/full

#ArterioVenousFistula #EndMT

Low #OscillatoryShearStress->
Osteopontin-CD44 in #EndothelialCell->
EndMT->
24% of neointimal cells at rat aortocaval junction

A cascade independent of #HyaluronicAcid

Dr. Yung-Hsin Yeh lab Kidney Int 2023
https://www.kidney-international.org/article/S0085-2538(23)00011-X/fulltext