#JACS
These are public posts tagged with #JACS. You can interact with them if you have an account anywhere in the fediverse.
A novel bifunctional molecule induces selective nitrosation of BTK. Mechanistically, it first covalent bind to BTK and the release NO, which yielded in the nitrosation of a cysteine side chain. Published in #JACS by Jiangbing Wu, Zhangjian Huang and coworkers (#China)
Read more on doi: 10.1021/jacs.5c07409 or on my page: https://me.organicchemistry.eu/post/nitrosation-jacs-2025/
When you think of a reaction between an acid and an alcohol, you think of an ester as the product. MacMillan and co-workers from Princeton have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. Read more about this in JACS:
Novel enantioselective #synthesis of rubriflordilactone B by Gui and colleagues from the Chinese Academy of Science published in #JACS
This is already the second total synthesis of this group, with an interesting reaction cascade as the key reaction in this process.
Luo et al. from Tsinghua University (#China) report in #JACS a novel method to create enantioenriched α-amino aldehydes using a chiral amine catalyst and iridium photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised and subsequently stabilised via analogues formation (e.g. through Wittig reaction).
https://me.organicchemistry.eu/post/deracemization-aldehyde-jacs-2025/
Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS
https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/
Another total synthesis in the spotlight: Already early this year Mingji Dai and his research team described the total synthesis of heilonine in #JACS (doi: 10.1021/jacs.3c13492). This synthesis is short and elegant, using multiple C-H functionalisations and a Nazarov cyclisation for their key step.
Heilonine is an alkaloid isolated in 1989 from Fritillaria…
www.organicchemistry.euEfficient Synthesis of ProTide antivirals: A team from from #Fudan University and #Shanghai Jiao Tong University reporting a copper-catalyzed method for synthesizing chiral phosphates in #JACS.
This research represents a new tool for the synthesis of ProTide nucleoside analogues, providing an efficient route that can enhance the development of antiviral drugs in future studies.
My evening lecture: Total synthesis of cylindrocyclophane A by Davies and Craig published in #Science and the stereoselective synthesis of protides by Shang published in #JACS
Nostalgic toot warning! 
We often celebrate birthdays 
of #scientists whose research was impactful on our lives.
But is marking the publication anniversary of research that was a #TurningPoint in our #science career a thing? 
If so, a 40th anniversary toot to a #JACS paper that will remain relevant as long as #chemistry students learn about Ron Gillespie’s #VSEPR model and #chemists use it to intuitively understand the shapes of molecules.
https://pubs.acs.org/doi/abs/10.1021/ja00318a009
My Reading Tip of the Week:
Scabrolide A, a polycyclic marine natural product, has fascinated chemists due to its highly constrained structure. Recently, Pengfei Hu and colleagues from Westlake University in Hangzhou, China, published an innovative radical cascade strategy for efficiently synthesizing the scaffold of this polycyclic compound.
Divergent Synthesis of Scabrolide A and Havellockate via an exo-exo-endo Radical Cascade doi:10.1021/jacs.4c03995
Happy to see this cover I made for the nice work of Raquel Galian and colleagues published in the American Chemical Society Journal #JACS! The article shows how #BODIPY dyes anchored to #perovskite nanocrystals behave differently depending on their structure, showing #HotCarriers extraction and Förster resonance energy transfer (#FRET).
here the link to the paper: https://pubs.acs.org/doi/10.1021/jacs.3c14335
Der Krankenhauskeim 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 
ist auch wegen seiner Resistenz gegen zahlreiche #Antibiotika gefährlich. Ein Forschungsteam der @HHU und des Forschungszentrums Jülich hat nun einen Mechanismus gefunden, der es ermöglicht, die Virulenz des Keims abzuschwächen. Auf diesem Wissen aufbauend kann ein neuer Ansatz für Antibiotika 
entwickelt werden, wie die Autoren in der Fachzeitschrift #JACS Au darlegen. https://www.fz-juelich.de/de/aktuelles/news/meldungen/2024/neuer-ansatz-fuer-antibiotikaentwicklung
Melognine was thought to be a highly complex alkaloid with a polycyclic ring system. Yui Irie and Satoshi Yokoshima (Nagoya University, #Japan) published a total synthesis of the proposed structure in the journal #JACS. However, the synthesised structure turned out to have different analytical properties. The authors concluded that melognine is actually identical to melodinine L. Check out the intriguing total synthesis route on JACS:
https://pubs.acs.org/doi/10.1021/jacs.4c02086
Using the Bunsen burner for the final step of a complex total synthesis?
#OpenAccess #TotalSynthesis of Euphorikanin A by Erick Carreira and colleagues from #ETH Zurich (#Switzerland) published in #JACS. A late-stage atrospecific cascade reaction led to the core structure of the terpene and pyrrolysis finally yielded the natural product.
The #TotalSynthesis of highly condensed polycyclic terpenoids has been a hot topic in #Chemistry recently. Yandong Zhang (#Xiamen University, #China) and co-workers now were able to synthesize such complex terpenes by epoxide-ene cyclization, oxygenation, and subsequent skeletal rearrangement. Read more about this protecting group free total synthesis in #JACS: https://pubs.acs.org/doi/10.1021/jacs.3c06442
Synthesis of highly complex terpenoids reported by Shuanhu Gao and co-workers from the East China Normal #University (#Shanghai #China). Cephinoid P and other related terpenoids were accessible by Nicholas/Hosomi-Sakurai cascade reaction and Pauson-Khand reaction. Published in #JACS
#TotalSynthesis of Waixenicin A, 9-Deacetoxy-14,15-deepoxyxeniculin and Xeniafaraunol A by Thomas Magauer and colleagues (#University of #Innsbruck @uniinnsbruck #Austria) published recently in #JACS featuring an unusual alkylation ring closing strategy.
#chemistry #organicchemistry @chemistry https://pubs.acs.org/doi/10.1021/jacs.3c03366
The beauty of spirocyclic compounds: Total synthesis of illisimonin A by Markus Kalesse and co-workers from the University Hannover published recently in #JACS
Nazarov/ene cyclization lead to key intermediate for the #synthesis of this terpenoid.
Stephadiamine is a popular synthetic challenge which resulted in many total syntheses before. Now, Jieping Zhu (EPFL, Lausanne) and co-workers were able to report in #JACS a new route to the #alkaloid with a hasubanan core structure featuring a diastereoselective intramolecular dipolar cycloaddition.
Latest #paper from the group, in #JACS! Chamoni and co-workers demonstrate #polymer materials that undergo "fueled" transient changes in mechanical properties on treatment with carbodiimides, enabling cool applications like temporary adhesion and rewriteable film patterning.
Part of our long collaboration with @konkol, with materials characterization help from the Sparks group, both at #MiamiUniversity
