#macrophage

These are public posts tagged with #macrophage. You can interact with them if you have an account anywhere in the fediverse.

Auscandoc

bbc.com/news/articles/c1wwdd6v “The group of researchers at the Francis Crick Institute and University College London performed a deep genetic analysis to try to unpick the cause of the #IBD.
They discovered a section of genetic code – or #DNA – that turns out to be the #macrophage’s “master regulator” of #inflammation.
It sits right at “the top of the pyramid” says Dr James Lee, from the Francis Crick Institute. (1/2)

Major cause of inflammatory bowel disease found

Scientists have found a weak spot in our DNA that is…

www.bbc.com
Jun 06, 2024, 17:15 · · 1 · 0
katch wreck

"Backpacks durably adhered to the surface of macrophages without internalization & maintained an anti-inflammatory phenotype of the carrier macrophage through 7 days in vitro. Backpack-macrophage therapy was scaled up & safely infused into piglets in a cortical impact Traumatic brain injury (TBI) model..The results..demonstrate..the first use of a cell therapy intervention for a large animal model of #TBI & highlight the potential of #macrophage-based #therapy"

academic.oup.com/pnasnexus/adv

Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury

Abstract. Traumatic brain injury (TBI) is a debilitating…

academic.oup.com
Jan 04, 2024, 04:57 · · 0 · 0
AM_Connors

Attending #SETACLouisville and interested in #PFAS and the #immune system? You’re in luck! 🧵

My virtual talk on how PFAS impact #macrophage function is available to view now! Just search for my name or “1.05.V-030” on the meeting platform.

#SETAC
1/3

Nov 13, 2023, 22:58 · · 0 · 0
Amro Hussien

Macrophage immune memory in inflammatory arthritis

"Pro-inflammatory cytokines, DAMPs & PAMPS constitute triggers that induce metabolic and epigenetic reprogramming, leading to #macrophage memory in inflammatory arthritis."

nature.com/articles/s4158

Oct 15, 2023, 18:48 · · 0 · 0
Amro Hussien

Obesity confers #macrophage memory

◽️Obesity triggers #epigenetic reprogramming of the innate immunity, lasting long after return to normal weight

◽️Stearic fatty acid (via TLR4) remodels chromatin & ↑AP-1 accessibility

◽️MΦ shift OXPHOS→ glycolysis

science.org/doi/10.1126/scienc

Oct 14, 2023, 21:57 · · 3 · 0
The EMBO Journal

#Macrophage-derived #insulin antagonist ImpL2 causes #lipoprotein mobilization upon bacterial #infection
Adam Bajgar, Tomas Dolezal and coworkers, University of South Bohemia
embopress.org/doi/full/10.1525

Oct 09, 2023, 10:05 · · 2 · 0
Thiago Carvalho

'LPS induced a sustained increase in IFNγ levels and unresolvable inflammatory lung injury in the mice lacking RGS2 but not in RGS2 null chimeric mice receiving WT bone marrow or receiving the RGS2 gene in alveolar #macrophage.'

#Preprint #immunology


biorxiv.org/content/10.1101/20

RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury

IFNγ, a type II interferon secreted by immune cells…

www.biorxiv.org
Sep 25, 2023, 08:21 · · 3 · 2
The EMBO Journal

#lncRNAs can affect #macrophage M1/M2 polarization:
@mimaseestern et al @Savai_Lab @mpi_hlr find ADPGK-AS1 expression associated with tumor-associated macrophages to alter metabolic and phenotypic states to drive #lungcancer growth
embopress.org/doi/full/10.1525

Aug 16, 2023, 15:00 · · 0 · 0
Gabriele Pollara

Macrophages aren't defined by binary M1 & M2 classification, but are plastic and come in many flavours.

Here it's expression of CXCL9 and SPP1, and it associated with tumour microenvironment.

#immunology #cancer #tumor #macrophage #science #ScienceMastodon

science.org/doi/abs/10.1126/sc

Aug 03, 2023, 20:57 · · 2 · 0

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