#medchem
These are public posts tagged with #medchem. You can interact with them if you have an account anywhere in the fediverse.
Opportunity for medicinal chemist in #DrugDiscovery #AI at Novartis (Cambridge MA USA) ref: REQ-10025404 #MedChem #cheminformatics #ML #ChemJobs #chemsky 
www.novartis.com/careers/care...
https://www.novartis.com/careers/career-search/job/details/req-10025404-us-lead-ai-discovery-chemistry-ai4d
Efficient Synthesis of ProTide antivirals: A team from from #Fudan University and #Shanghai Jiao Tong University reporting a copper-catalyzed method for synthesizing chiral phosphates in #JACS.
This research represents a new tool for the synthesis of ProTide nucleoside analogues, providing an efficient route that can enhance the development of antiviral drugs in future studies.
Today is day 4 of the #EFMC International symposium on medical chemistry in #Rome. Had some interesting talks about my research on #antivirals. #MedChem #Chemistry
For everyone interested in the synthesis of #antiviral #drugs:
I collected 7 synthesis routes for #entecavir, a marketed #HBV antiviral. At first sight, this carbocyclic nucleoside analogue looks quite simple, however, its synthesis requires a multi-step total synthesis.
Check the article for further information and share it with your audience:
https://www.organicchemistry.eu/books/nucleoside-analogues/page/synthesis-strategies-for-entecavir
I am happy to share my recent publication in #OrgLett 
We synthesized carbobicyclic nucleoside analogues which appear to be potent #antivirals against #RSV Despite their novel bicyclic structure, they adopt a ribose-like structure. This may be a new template for novel nucleoside analogues.
https://pubs.acs.org/doi/10.1021/acs.orglett.3c03590
Next step: Explore the mechanism of action.
#chemistry #medchem #virus #science #research #CUHK #HongKong
![Abstract picture of doi: 10.1021/acs.orglett.3c03590 shows the synthetic concept of the study. In detail bicyclo[4.3.0]nonene type nucleoside analogues are proposed as new antivirals. They are synthesized from acetonide protected 4,5-dihydroxycyclopent-2-en-1-one by intermolecular Diels Alder reaction.](https://fediscience.org/system/media_attachments/files/111/542/039/806/171/743/original/f2180dbacf95c705.jpeg "Abstract picture of doi: 10.1021/acs.orglett.3c03590 shows the synthetic concept of the study. In detail bicyclo[4.3.0]nonene type nucleoside analogues are proposed as new antivirals. They are synthesized from acetonide protected 4,5-dihydroxycyclopent-2-en-1-one by intermolecular Diels Alder reaction.")
This enhances the efficacy of various classes of antibiotics by 32-512 fold, without inducing toxicity towards mammalian cells. The leading combination also disrupts mature multispecies biofilms composed of A. baumannii and methicillin-resistant Staphylococcus aureus (MRSA), which is typically resistant to most antibiotics.
#ChemSciPicks #medchem #AntibioticResistance #antibiotic
Are there non-phosphorylated nucleoside analogs that act as inhibitors of viral polymerase?
@Nature @SciReports
#CompChem #MedChem #ML #AI #MachineLearning
@unitartu @1Healthdrugs_ca @COSTprogramme @cnr_scitec @CSIR_IHBT #ArtificialInteligence #RealTimeChem
https://www.nature.com/articles/s41598-023-44264-7
Drug repurposing: a nexus of innovation, science, and potential
Maria Cristina De Rosa, Rituraj Purohit & Alfonso T. García-Sosa
Scientific Reports volume 13, Article number: 17887 (2023)
RT @conway_group: Our 'Mutate and Conjugate' paper is out now in ACS Chem Biol (@ACSBioMed)! We combine site-directed mutagenesis and electrophilic fragments to identify inhibitors the mutant protein with a view to helping target validation.
https://t.co/hN0oOHupVy
#chembiol #medchem https://t.co/lOn8k7F23C
I always enjoy sharing Eline's work. She was a close collaborator during graduate school at UCSF.
With colleagues, Eline has extended the project we worked on together 5+ years ago and done the near-impossible: graft a covalent and non-covalent fragment into a PPI stabilizer.
Check it out!
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202308004
#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200
Chung K. Chu and colleagues from #Georgia University (#Athens #USA) published in the Journal of Medical Chemistry the synthesis and biological evaluation of several prodrug strategies for l-BHDU against Varicella Zoster Virus. #antivirals #chemistry #medchem
Our review on cannabinoid derivatives just got accepted at Org Biomol Chem, and you can read the preprint here.
This review discusses advanced derivatization strategies for the major cannabinoids, where the starting material is the pure phytocannabinoid itself, and the final product either a cannabinoid pro-drug, or a novel pharmacoactive material.
#cannabis #research #API #medchem
https://chemrxiv.org/engage/chemrxiv/article-details/63bef4391f1258c73a9a22b5
Tetrahydrocannabinol (THC) and cannabidiol (CBD) are…
chemrxiv.orgSmall review about synthetic routes to #antiviral #drug remdesivir. Including first described synthesis by Gilead in #Nature, but also the approach from Benjamin List in Angewandte Chemie.
What a nice late Christmas present to see this out in #JACS now. This paper shows how chemical proteomics can assist target deconvolution in the discovery of new covalent antibiotics against MRSA. Great work by first authors Alexander Bakker and Ioli Kotsogianni from the groups of @mariovdstelt and Nathaniel Martin. Happy that the work I did for my master’s thesis could contribute to this story. @LED3hub
#MedChem #DrugDiscovery #ChemicalBiology
https://pubs.acs.org/doi/10.1021/jacs.2c10819
I wrote a short excerpt about the #SARS-CoV-2 #antiviral VV116 which was developed in #China. Structurally, it resembles #remdesivir but esterification led to much better bioavailability. Therefore, it can be administered orally.
Any opinions on this nucleoside analogue?
@chemistry #chemistry #medchem
https://www.organicchemistry.eu/books/nucleoside-analogues/page/sars-cov-2-antiviral-vv116
Feel free to give us a follow here (or on the bird site @gunninglabuoft) to keep up with the latest research and news from our group and to see posts about cool new papers in #medchem, #chemicalbiology, and #drugdiscovery!
Design of CD73 #inhibitor|s
Introduction of 3' alkynyl moiety led to drastically improved antitumor activity. E. B. Sjogren and colleagues from Calithera Biosciences described the synthesis of these orally available nucleoside analogues in the Journal of Medicinal #Chemistry.
