#Microglia
These are public posts tagged with #Microglia. You can interact with them if you have an account anywhere in the fediverse.
Article from the leading publication Life Sciences Magazine featuring masitinib and its Phase 3 principal investigator, the neurologist Patrick Vermersch https://www.byteseu.com/798060/ #ABScience #AmyotrophicLateralSclerosis #BreakthroughTreatment #EuronextParis #InflammatoryDiseases #MastCells #microglia #MultipleSclerosis #neuroinflammation #Parkinson'sDisease #PATRICKVERMERSCH #Science
https://www.europesays.com/1888321/ Article from the leading publication Life Sciences Magazine featuring masitinib and its Phase 3 principal investigator, the neurologist Patrick Vermersch #ABSCIENCE #america #AmyotrophicLateralSclerosis #BreakthroughTreatment #EuronextParis #InflammatoryDiseases #MastCells #microglia #MultipleSclerosis #neuroinflammation #Parkinson'sDisease #PATRICKVERMERSCH #science #technology #UnitedStates #UnitedStatesOfAmerica #US #USA
@rod2ik@mastodon.socialDescubierto el mecanismo de la “ #microglía #oscura ”, una posible #causa del #alzhéimer
El hallazgo podría facilitar el desarrollo de fármacos…
El País
@ameliacervera@genomic.socialElevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction.
#Transposons #TEs #Alzheimer #LOAD #LINE1 #Microglia
https://link.springer.com/article/10.1007/s00401-024-02835-6
New #microglia #morphology analysis pipeline. Looks useful!
MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features
Benkeder et al., reviewed preprint at eLife 2024
https://doi.org/10.7554/eLife.101630.1
Microglia can selectively clear neurons, but what else do they eat? @FChrisBennett & @nachoriko explore a #PLOSBiology study showing that #microglia also cannibalize other microglia, followed by microglial necroptosis Primer: https://plos.io/4f7sXEs Paper: https://plos.io/3Aj1JvE
Microglia are considered long lived, but @cssmity &co show that individual embryonic #microglia die within 3 days after clearing neural debris and are cannibalized by existing microglia, paradoxically leading to additional microglial death #PLOSBiology https://plos.io/3Aj1JvE
"Here, we show that microglia in the mediobasal hypothalamus (MBH) of mice actively engage in synaptic pruning during early life. Microglial phagocytic activity is induced following birth, regresses upon weaning from maternal milk, and is exacerbated by feeding dams a high-fat diet while lactating. In particular, we show that microglia refine perineuronal nets (PNNs) within the neonatal MBH."
https://www.biorxiv.org/content/10.1101/2024.07.02.601752v1?ct=
Mammalian glucose homeostasis is, in part, nutritionally…
www.biorxiv.org"Taken together, our study demonstrates that members of the Bacteroidota phylum contribute to AD pathogenesis by suppressing microglia phagocytic function, which leads to impaired Aβ clearance and accumulation of amyloid plaques."
Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models
Wasén et al., Nature Communications 2024
https://doi.org/10.1038/s41467-024-47683-w
#neuroscience #gutbacteria #microbiome #microglia #gutbrainaxis
"Long-term microglia depletion using colony-stimulating-factor-1 receptor (CSF1-R) inhibitor PLX5622 resulted in increased overall spine density, especially of mushroom spines, and increased excitatory postsynaptic current amplitudes."
Repopulated microglia after pharmacological depletion decrease dendritic spine density in adult mouse brain
Wickel et al., Glia 2024
https://doi.org/10.1002/glia.24541
News to me: Local translation isn't limited to neurons, apparently also happens in glial processes. See here for #microglia:
Local translation in microglial processes is required for efficient phagocytosis
Vasek et al., Nature Neuroscience 2023
https://doi.org/10.1038/s41593-023-01353-0
The accompanying news & views write-up has a useful overview figure: https://doi.org/10.1038/s41593-023-01370-z
@nemo@mas.to#Gammafrequency entrainment attenuates #amyloid load and modifies #microglia
Mast cells and neuroinflammation and blood-brain-barrier dysfunction
"Mast cell activation and degranulation destroyed the tight junction proteins in brain microvascular endothelial cells and induced the activation and proliferation of microglia.
#LongCovid Neuro inflammation
#Microglia
#Covid19
"We discuss preclinical evidence related to both neuronal & nonneuronal mechanisms that may be involved, touching upon the relevance of #interneurons, neuropeptides, & specific synaptic mechanisms in translating gamma stimulation into widespread neuronal activity within the brain. We also explore the roles of #microglia, #astrocytes, & the vasculature in mediating the beneficial effects of gamma stimulation on #brain function. Lastly, we examine upcoming clinical trials"
Transcriptional profiling of phagocytic leukocytes and microglia reveals a critical role for reactive oxygen species in biofilm containment during Staphylococcus aureus craniotomy infection. https://doi.org/10.4049/jimmunol.2200503 #StaphylococcusAureus #Biofilm #CraniotomyInfection #Microglia #Neutrophils
LOOI MK.
“We weren’t that great at treating flu-it should not be our model for covid”:
America’s covid-19 tsar speaks.
BMJ. 2023;383:p2743.
PubMed: https://www.amedeo.com/p2.php?id=38030216&s=cov&pm=2
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DYER O.
Pfizer sues Poland over unclaimed covid vaccines.
BMJ. 2023;383:2810.
PubMed: https://www.amedeo.com/p2.php?id=38016715&s=cov&pm=2
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LOOI MK.
China: Rising cases of respiratory disease and pneumonia spark WHO concern.
BMJ. 2023;383:2770.
PubMed: https://www.amedeo.com/p2.php?id=37996101&s=cov&pm=2
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RIMMER A.
Clinicians with long covid must get financial support, say unions.
BMJ. 2023;383:2723.
PubMed: https://www.amedeo.com/p2.php?id=37977571&s=cov&pm=2
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HEANEY CD, Hempel H, DeRosa KL, Pinto LA, et al.
Clinical Assessment of SARS-CoV-2 Antibodies in Oral Fluids Following Infection
and Vaccination.
Clin Chem. 2023 Dec 1:hvad169. doi: 10.1093.
PubMed: https://www.amedeo.com/p2.php?id=38039096&s=cov&pm=2
ABSTRACT available
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CHEUNG YYH, Lau EHY, Yin G, Lin Y, et al.
Effectiveness of Vaccines and Antiviral Drugs in Preventing Severe and Fatal
COVID-19, Hong Kong.
Emerg Infect Dis. 2023;30.
PubMed: https://www.amedeo.com/p2.php?id=38040664&s=cov&pm=2
ABSTRACT available
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HUANG PY, Lai CC, Hsu CK.
Assessing risk factors for COVID-19 pneumonia in Chinese patients with
pre-existing interstitial lung disease.
J Med Virol. 2023;95:e29281.
PubMed: https://www.amedeo.com/p2.php?id=38038270&s=cov&pm=2
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WU JY, Liu MY, Hung KC, Hsu WH, et al.
Nutritional deficiency anemia and post-acute sequelae in patients with severe
acute respiratory syndrome coronavirus 2 infection: A six-month retrospective
cohort analysis of 30 892 patients.
J Med Virol. 2023;95:e29246.
PubMed: https://www.amedeo.com/p2.php?id=38010833&s=cov&pm=2
ABSTRACT available
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KANG SW, Kim JW, Kim JY, Lim SY, et al.
Virological characteristics and the rapid antigen test as deisolation criteria in
immunocompromised patients with COVID-19: A prospective cohort study.
J Med Virol. 2023;95:e29228.
PubMed: https://www.amedeo.com/p2.php?id=38009999&s=cov&pm=2
ABSTRACT available
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LI Z, Xiong Y, Long J, Li T, et al.
Resurgence of influenza during COVID-19 in Chongqing, China: A retrospective
analysis.
J Med Virol. 2023;95:e29249.
PubMed: https://www.amedeo.com/p2.php?id=38009822&s=cov&pm=2
ABSTRACT available
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CHENANE HR, Lingas G, Menidjel R, Laouenan C, et al.
High sera levels of SARS-CoV-2 N antigen are associated with death in
hospitalized COVID-19 patients.
J Med Virol. 2023;95:e29247.
PubMed: https://www.amedeo.com/p2.php?id=38009713&s=cov&pm=2
ABSTRACT available
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WANG Z, Zhao C, Li C, Liu S, et al.
Molecular PET/CT mapping of rhACE2 distribution and quantification in organs to
aid in SARS-CoV-2 targeted therapy.
J Med Virol. 2023;95:e29221.
PubMed: https://www.amedeo.com/p2.php?id=38009705&s=cov&pm=2
ABSTRACT available
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HU GM, Tai YC, Chen CM.
Unraveling the evolutionary patterns and phylogenomics of coronaviruses: A
consensus network approach.
J Med Virol. 2023;95:e29233.
PubMed: https://www.amedeo.com/p2.php?id=38009694&s=cov&pm=2
ABSTRACT available
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MAO R, Fan Z, He M, Li J, et al.
Acne and COVID-19 susceptibility, hospitalization, and severity: A genetic
correlation study.
J Med Virol. 2023;95:e29265.
PubMed: https://www.amedeo.com/p2.php?id=38009619&s=cov&pm=2
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KONDO Y, Kawamura Y, Hattori F, Nakai H, et al.
Serological analysis of severe acute respiratory syndrome coronavirus 2 infection
in children with Kawasaki disease.
J Med Virol. 2023;95:e29274.
PubMed: https://www.amedeo.com/p2.php?id=38009251&s=cov&pm=2
ABSTRACT available
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BOYD S, Matsee W, Pisutsan P, Kamolrattanakul S, et al.
Incidence and Influencing Factors of Psychological Problems among International
Travelers During Quarantine.
J Travel Med. 2023 Nov 25:taad151. doi: 10.1093.
PubMed: https://www.amedeo.com/p2.php?id=38006361&s=cov&pm=2
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ZAYOU L, Prakash S, Dhanushkodi NR, Quadiri A, et al.
A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the
frequency and the function of lung-resident memory CD4(+) and CD8(+) T cells and
enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2
infection.
J Virol. 2023 Dec 1:e0109623. doi: 10.1128/jvi.01096.
PubMed: https://www.amedeo.com/p2.php?id=38038432&s=cov&pm=2
ABSTRACT available
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SO RTY, Chu DKW, Hui KPY, Mok CKP, et al.
Amino acid substitution L232F in non-structural protein 6 identified as a
possible human-adaptive mutation in clade B MERS coronaviruses.
J Virol. 2023 Dec 1:e0136923. doi: 10.1128/jvi.01369.
PubMed: https://www.amedeo.com/p2.php?id=38038429&s=cov&pm=2
ABSTRACT available
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LI K, Huntwork RHC, Horn GQ, Abraha M, et al.
Cryptic-site-specific antibodies to the SARS-CoV-2 receptor binding domain can
retain functional binding affinity to spike variants.
J Virol. 2023 Nov 29:e0107023. doi: 10.1128/jvi.01070.
PubMed: https://www.amedeo.com/p2.php?id=38019013&s=cov&pm=2
ABSTRACT available
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YANG S, Huang X, Li S, Wang C, et al.
Linoleic acid: a natural feed compound against porcine epidemic diarrhea disease.
J Virol. 2023 Nov 27:e0170023. doi: 10.1128/jvi.01700.
PubMed: https://www.amedeo.com/p2.php?id=38009930&s=cov&pm=2
ABSTRACT available
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WANG Z, He W, Li C, Chen Y, et al.
The role of lysosomes as intermediates in betacoronavirus PHEV egress from nerve
cells.
J Virol. 2023 Nov 27:e0133823. doi: 10.1128/jvi.01338.
PubMed: https://www.amedeo.com/p2.php?id=38009916&s=cov&pm=2
ABSTRACT available
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NARAYANAN KK, Amaya M, Tsang N, Yin R, et al.
Sequence basis for selectivity of ephrin-B2 ligand for Eph receptors and
pathogenic henipavirus G glycoproteins.
J Virol. 2023;97:e0062123.
PubMed: https://www.amedeo.com/p2.php?id=37931130&s=cov&pm=2
ABSTRACT available
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SCHMIDT M, Hajage D, Lebreton G, Dres M, et al.
Prone Positioning During Extracorporeal Membrane Oxygenation in Patients With
Severe ARDS: The PRONECMO Randomized Clinical Trial.
JAMA. 2023 Dec 1. doi: 10.1001/jama.2023.24491.
PubMed: https://www.amedeo.com/p2.php?id=38038395&s=cov&pm=2
ABSTRACT available
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EASTMAN Q.
Study Shows Businesses Selling Unapproved Stem Cell Treatments Have Turned to
Long COVID.
JAMA. 2023 Nov 29. doi: 10.1001/jama.2023.23897.
PubMed: https://www.amedeo.com/p2.php?id=38019493&s=cov&pm=2
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BERGMAN C.
Treatment of SARS-CoV-2 Infection in US Nursing Homes.
JAMA. 2023;330:2021-2022.
PubMed: https://www.amedeo.com/p2.php?id=38015226&s=cov&pm=2
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MCGARRY BE, Sommers BD, Barnett ML.
Treatment of SARS-CoV-2 Infection in US Nursing Homes-Reply.
JAMA. 2023;330:2022.
PubMed: https://www.amedeo.com/p2.php?id=38015222&s=cov&pm=2
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HARRIS E.
Audit Finds US National Stockpile “Was Not Equipped” for the Pandemic.
JAMA. 2023;330:1828.
PubMed: https://www.amedeo.com/p2.php?id=37910119&s=cov&pm=2
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VALENCIA D, Yu AT, Wheeler A, Hopkins L, et al.
Notes from the Field: The National Wastewater Surveillance System’s Centers of
Excellence Contributions to Public Health Action During the Respiratory Virus
Season – Four U.S. Jurisdictions, 2022-23.
MMWR Morb Mortal Wkly Rep. 2023;72:1309-1312.
PubMed: https://www.amedeo.com/p2.php?id=38032883&s=cov&pm=2
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TANNIS A, Englund JA, Perez A, Harker EJ, et al.
SARS-CoV-2 Epidemiology and COVID-19 mRNA Vaccine Effectiveness Among Infants and
Children Aged 6 Months-4 Years – New Vaccine Surveillance Network, United States,
July 2022-September 2023.
MMWR Morb Mortal Wkly Rep. 2023;72:1300-1306.
PubMed: https://www.amedeo.com/p2.php?id=38032834&s=cov&pm=2
ABSTRACT available
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CALLAWAY E.
These volunteers want to be infected with disease to aid research – will their
altruism help?
Nature. 2023 Nov 28. doi: 10.1038/d41586-023-03583.
PubMed: https://www.amedeo.com/p2.php?id=38017067&s=cov&pm=2
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CONROY G.
What’s behind China’s mysterious wave of childhood pneumonia?
Nature. 2023 Nov 27. doi: 10.1038/d41586-023-03732.
PubMed: https://www.amedeo.com/p2.php?id=38012356&s=cov&pm=2
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JAIN V.
Infection Control and Prevention During the COVID-19 Pandemic.
Clin Infect Dis. 2023 Nov 30:ciad611. doi: 10.1093.
PubMed: https://www.amedeo.com/p2.php?id=38031388&s=cov&pm=2
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USDAN L, Patel S, Rodriguez H, Xu X, et al.
A Bivalent Omicron-BA.4/BA.5-Adapted BNT162b2 Booster in >/=12-Year-Olds.
Clin Infect Dis. 2023 Nov 28:ciad718. doi: 10.1093.
PubMed: https://www.amedeo.com/p2.php?id=38016021&s=cov&pm=2
ABSTRACT available
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LEE N, Nguyen L, Austin PC, Brown KA, et al.
Protection conferred by COVID-19 vaccination, prior SARS-CoV-2 infection, or
hybrid immunity against Omicron-associated severe outcomes among
community-dwelling adults.
Clin Infect Dis. 2023 Nov 24:ciad716. doi: 10.1093.
PubMed: https://www.amedeo.com/p2.php?id=38001037&s=cov&pm=2
ABSTRACT available
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GRANEROD J, Huang Y, Davies NWS, Sequeira PC, et al.
Global Landscape of Encephalitis: Key Priorities to Reduce Future Disease Burden.
Clin Infect Dis. 2023;77:1552-1560.
PubMed: https://www.amedeo.com/p2.php?id=37436770&s=cov&pm=2
ABSTRACT available
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DE LUSIGNAN S, Hobbs FR, Sheikh A.
Lessons from the English primary care sentinel network’s response to the COVID-19
pandemic.
Lancet Infect Dis. 2023 Nov 28:S1473-3099(23)00736.
PubMed: https://www.amedeo.com/p2.php?id=38040007&s=cov&pm=2
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GOTTLIEB RL, Paredes R.
Oral and intravenous 1′-cyano-substituted adenosine-like antivirals for early
COVID-19.
Lancet Infect Dis. 2023 Nov 22:S1473-3099(23)00633.
PubMed: https://www.amedeo.com/p2.php?id=38006893&s=cov&pm=2
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FAN X, Dai X, Ling Y, Wu L, et al.
Oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China: a
multicentre, double-blind, phase 3, randomised controlled study.
Lancet Infect Dis. 2023 Nov 22:S1473-3099(23)00577.
PubMed: https://www.amedeo.com/p2.php?id=38006892&s=cov&pm=2
ABSTRACT available
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BURKI T.
UK Covid-19 Inquiry.
Lancet Infect Dis. 2023;23:e516-e517.
PubMed: https://www.amedeo.com/p2.php?id=38006889&s=cov&pm=2
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BAGCCHI S.
Boost for COVID-19 testing in the USA.
Lancet Infect Dis. 2023;23:e514.
PubMed: https://www.amedeo.com/p2.php?id=38006887&s=cov&pm=2
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WANG S, Cui H, Zhang C, Li W, et al.
Oral delivery of a chitosan adjuvanted COVID-19 vaccine provides long-lasting and
broad-spectrum protection against SARS-CoV-2 variants of concern in golden
hamsters.
Antiviral Res. 2023 Nov 28:105765. doi: 10.1016/j.antiviral.2023.105765.
PubMed: https://www.amedeo.com/p2.php?id=38036065&s=cov&pm=2
ABSTRACT available
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FORRESTALL K, Pringle ES, Sands D, Duguay BA, et al.
A phenothiazine urea derivative broadly inhibits coronavirus replication via
viral protease inhibition.
Antiviral Res. 2023;220:105758.
PubMed: https://www.amedeo.com/p2.php?id=38008194&s=cov&pm=2
ABSTRACT available
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SUBRAMANI C, Sharma G, Chaira T, Barman TK, et al.
High content screening strategies for large-scale compound libraries with a focus
on high-containment viruses.
Antiviral Res. 2023 Nov 24:105764. doi: 10.1016/j.antiviral.2023.105764.
PubMed: https://www.amedeo.com/p2.php?id=38008193&s=cov&pm=2
ABSTRACT available
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#betacoronavirus #coronavirus #covid #COVID19 #microglia #mitochondria #neuroinflammation #research #sarbecovirus #sarsCov2
`Through unbiased analyses of #RNA and protein profiles in #Inositol polyphosphate-5-phosphatase D (INPP5D) -disrupted iPSC-derived human #microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted #autophagy and #inflammasome activation.. findings provide insights into the molecular mechanisms underlying microglia-mediated processes in #AD and highlight the inflammasome as a potential #therapeutic target`
"Whether and how microglia surveillance is coupled to brain state switches during natural sleep-wake cycles remain unclear. To address this question, we used miniature two-photon microscopy (mTPM) to acquire time-lapse high-resolution microglia images of the somatosensory cortex, along with EEG/EMG recordings and behavioral video, in freely-behaving mice."
Microglia surveillance manifests itself as dynamic…
www.biorxiv.orgResearchers from university labs in the U.K. are developing models of brain cell interactions using a company's synthetic human cells derived from stem cells.
https://sciencebusiness.technewslit.com/?p=45434
#News #Press #Science #Business #Biotechnology #Neuroscience #Brain #StemCells #SyntheticBiology #CellBiology #Collaboration #Neurons #Microglia #UK
Researchers from university labs in the U.K. are developing…
Science and Enterprise"Animals lacking microglia show increased metastasis, decreased survival and reduced natural killer and T cell responses, showing that microglia are critical to promote anti-tumour immunity to suppress breast cancer brain metastasis."
#Immunology #TumorImmunology #Microglia