#MultiTarget

#MultiTarget tracking airborne #radar systems have been implemented using traditional #statistical techniques. Blackman's 1986 textbook is the leading publication on this knowledge front.

Multi-target tracking is a sophisticated application of the fundamental idea behind the 1960s Kalman filter—sequence prediction—which began with the 1900s Markov chain. In the 2020s, #LLMs are perhaps the most appropriate technique for solving this difficult problem.

Happy to share our just accepted #review on #multitarget approaches for the #synthesis of #purine and #pyrimidine derivatives. From the #prebiotic/#abiotic origin of life to new #green #chemistry strategies for #drugdiscovery.
https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ejoc.202201288?utm_source=google&utm_medium=paidsearch&utm_campaign=R3MR425&utm_content=Chemistry

As additional Appendix to my #introduction, I would like to #boost our recent #DrugDiscovery efforts in the field of #CysticFibrosis: we have developed #MultiTarget compounds acting at the same time as #CFTR #Correctors and #Antibacterials or #Antivirals depending on the specific functionalization of the same chemotype.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202200277
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01416

Possible applications of #MultiTarget compounds in #ProxPharm Beyond PROTACs.

https://www.sciencedirect.com/science/article/pii/S2001037022005049

-Time for a short #Introduction-

I am a group leader in #MedicinalChemistry at the University of Parma. My lab combines #chemical & #computational techniques to develop novel pharmacological tools to study different Chronic Diseases (#CysticFibrosis, #IBD, #Hypercholesterolemia, #Alzheimer, #Cancer) and Infective Agents (#SARSCoV2, #Enterovirus, #Flavivirus, #Monkeypox, #HIV).
We are particularly interested in the development of #MultiTarget inhibitors and open to new #collaborations in #DrugDiscovery.
#Tooting (sooner or later) about the #chemistry and #science