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"However, T cell responses to dietary antigen have primarily been characterized using monoclonal T cell receptor (TCR) transgenic systems which do not represent a physiological immune response. Polyclonal CD4+ T cell responses to food, including TCR-specific selection and functional differentiation, remain largely uncharacterized and are critical for understanding mechanisms of tolerance and allergy."
Lockhart, @mucida et al
The intestinal immune system must tolerate food antigens…
www.biorxiv.org