#OscillatoryShearStress

#ArterioVenousFistula #EndMT

Low #OscillatoryShearStress->
Osteopontin-CD44 in #EndothelialCell->
EndMT->
24% of neointimal cells at rat aortocaval junction

A cascade independent of #HyaluronicAcid

Dr. Yung-Hsin Yeh lab Kidney Int 2023
https://www.kidney-international.org/article/S0085-2538(23)00011-X/fulltext

#EndothelialCell Mst1 KO->
EC inflammation by #OscillatoryShearStress 0.5±4 dyn/cm2 1 Hz
#Atherosclerosis

Independent of #YAP (?TAZ)

Mst1 phosphorylates #Connexin43->Hemichannel activity, not gap junction coupling

Dr. Ding Ai lab Circ Res 2022
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.122.321322