#PlosPathogens

Don't you just LOVE when a paper comes out providing an explanation for a long term lab question Mystery solved!!

This really nice paper just out in #PLOSpathogens
by @FirpoMason and @bryancmounce based at the Loyola University Chicago @LoyolaInDIRI. (a)

Our Question?

Our #SARSCoV2 humanized ACE2 mouse pathogenesis model paper is now out in #PLOSPathogens . Great effort from many and led by my great colleague Bev Koller.

We find that hACE2 expression is regulated by upstream and intragenic elements.

https://t.co/0FXCwRKXiy

Congrats @OggenfussUrsula et al!
#PLOSPathogens: Recent transposable element bursts are associated with the proximity to genes in a fungal pla ... https://dx.plos.org/10.1371/journal.ppat.1011130

Animal models for long Covid, review at #PlosPathogens

"We review SARS-CoV-2 infection and disease manifestations in mice, Syrian hamsters, ferrets, and nonhuman primates (NHPs). Specifically, the virology, pathology, immune responses, and multiorgan involvement are summarized. These models are rationally examined for their use in understanding the complexities of the multiorgan involvement during Long COVID and the potential for their use in screening therapeutics such as anti-inflammatory drugs, which are currently used for treating other diseases. The aim of this review is to highlight Long COVID preclinical animal models that could be used for Long COVID research and to screen for pharmacological interventions."

#Covid19 #LongCovid #Covid #SarsCoV2

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010741