Thiago Carvalho

"Runx co-factors compete to recruit a limited pool of Runx factors in early T-progenitors, and a modest increase in Runx protein availability at pre-commitment stages causes premature Runx occupancy at post-commitment binding sites. This results in striking T-lineage developmental acceleration by selectively activating T-identity and innate lymphoid cell programs."

#Immunology #Preprint #Runx #thymus

biorxiv.org/content/10.1101/20

Runx factors launch T-cell and innate lymphoid programs via direct and gene network-based mechanisms

Runx factors are essential for lineage specification…

www.biorxiv.org