#ShearStress

Our April issue is online today!

This month's cover highlights an article on #ShearStress control of vascular leaks and #atheromas.

Also in this issue: articles on #BreastCancer, #NeuralStemCells, #PrematureOvarianInsufficiency, #Psoriasis, #CLN1, & much more!

Fully #openaccess: https://www.embopress.org/toc/17574684/2023/15/4

High-throughout (50) high-res (<1.9 µm/px) blood flow imaging of whole #Zebrafish 2-6 dpf

Geometry
Velocity
Hematocrit
Viscosity
#ShearStress

Visualize the devepmental correlation b/w flow & vascular hierarchy

Dr. Li-Kun Phng lab Front Physiol 2022
https://www.frontiersin.org/articles/10.3389/fphys.2022.881929/full

A systematic map for zebrafish developmental hemodynamics

"stratification order of median levels of WSSpeak b/w vessel types was maintained in the anterior half... the posterior half had a different WSSpeak hierarchy...b/w 6 & 2 dpf"

#Biomechanics in vascular morphogenesis

Laminar #ShearStress reduces plasma leakage and #atheroma formation in atheroprotected regions of the aorta through downstream polarization and endocytosis of VE-PTP and resultant activation of #Tie2. #Atherosclerosis can be suppressed by inhibition of VE-PTP in atheroprone regions that lack VE-PTP sequestration.

By D. McDonald, D. Vestweber & colleagues at MPI for molecular biomedicine & UCSFCancer

https://doi.org/10.15252/emmm.202216128

5-channel (separated by microposts) #Microfluidic for #EndothelialCell-#Pericyte fibrin-
collagen co-culture

Human Lung fibroblast as feeder

Enable study of Synergy b/w #ShearStress & Pericyte on #SproutingAngiogenesis

Dr. Ryuji Yokokawa lab, Lab on a chip 2022

In the #2D #elasticity, #equilibrium of #stresses can be represented on an infinitesimal rectangular element with components of both #DirectStress and #ShearStress generally acting on all four edges. If you were to rotate the rectangle, the stresses change in a precisely orchestrated fashion. In the orientation where the shear stress components vanish, we get what are called #PrincipalStresses and they and their directions can be ascertained precisely through #eigenvalue analysis... 1/2