The EMBO Journal

#TFEB and #TFE3 control #glucose #homeostasis by regulating #insulin gene expression
Andrea Ballabio, Gennaro Napolitano and colleagues Tigem/Telethon
embopress.org/doi/full/10.1525

DaveFinlayTCD

Interesting 🤔. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.

A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1

doi.org/10.1126/science.abj555

The EMBO Journal

TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkers

Transcription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
embopress.org/doi/10.15252/emb

PLOS Biology

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology plos.io/3J5hcjn

PLOS Biology

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology plos.io/3J5hcjn

PLOS Biology

TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology plos.io/3J5hcjn