#TGFβ1
These are public posts tagged with #TGFβ1. You can interact with them if you have an account anywhere in the fediverse.
Happy to collaborate on this study profiling the existence and development of cross-tissue #ILC1 in humans.
https://doi.org/10.1016/j.celrep.2022.111937
Key Takeaways:
-Human ILC1 are rare in healthy liver, but accumulate in cirrhotic livers.
-Unknown #LSEC-derived signals + #TGFβ1 + #il7 drive differentiation of ILC progenitors to ILC1.
-Human #NK cells do not differentiate to ILC1 under multiple conditions ex vivo.
-Human ILC1 make #il2 but functional relevance of this still unknown.
Decoupling #TGFβ1 with phospho-SMAD2 (S457) & phospho-SMAD3 (S423/425) in ascending #AorticAneurysm with #BicuspidAorticValve or #UnicuspidAorticValve
How about TGFβ2/3?
As a comparison, in #TricuspidAorticValve aorta, diameter and elastin break correlate well with increased TGFβ1 level or p-SMAD2/3 levels
Dr. Brittany Balint & Hans-Joachim Schäfers lab, Sci Rep 2022
https://www.nature.com/articles/s41598-022-19335-w
