#Treg

Leggevo su un giornale generalista di una recentissima pubblicazione scientifica di una università in Svizzera riguardo ad un innovativo approccio nella ricerca di base per la cura della #celiachia (un'amica in classe di mia figlia è celiaca) con l'uso delle #Treg. Ovviamente il giornale si guarda bene da citare puntualmente dove sia tale pubblicazione come fonte, ma ok, con una rapida ricerca la trovo. Volevo leggermela più in dettaglio, ma è a pagamento

https://www.science.org/doi/abs/10.1126/scitranslmed.adr8941

'We found that up-regulation of a primate-specific short isoform of PRDM1-S induces expression of SGK1 independent from the evolutionarily conserved long PRDM1, which led to destabilization of #FOXP3 & #Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases.'
#Immunology
https://www.science.org/doi/10.1126/scitranslmed.adp1720

"The Swiss drugmaker also defenestrated three phase 1 programs. Anti-CD25 Treg depleter RG6292 landed on the discard pile. Roche previously stopped a monotherapy clinical trial but continued to study RG6292 in combination with its checkpoint inhibitor Tecentriq."
#Immunology #Treg
https://www.fiercebiotech.com/biotech/roche-pumps-brakes-pompe-axing-gene-therapy-after-assessing-competition

'Bender et al. report that a phase 2 randomized trial of a single dose of expanded Tregs showed no efficacy in preserving C-peptide, an indicator of β cell function, in early-onset T1D. This negative in vivo result comes despite the suppressive capacity of the expanded Tregs in vitro, and will inform future studies of the role of polyclonal Tregs in T1D.'
#Immunology #Immunotherapy #Treg #Diabetes
https://www.science.org/doi/full/10.1126/scitranslmed.adn2404

'However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysis of the transcriptomes of murine Treg and conventional T cells (Tconv), we observe that the proenkephalin gene (Penk), encoding the precursor of analgesic opioid peptides, ranks among the top 25 genes most enriched in Treg cells.'
#Immunology #Preprint #Neuroimmunology #Treg
https://www.biorxiv.org/content/10.1101/2023.09.12.557326v2

Attorney General Treg Taylor Joins 26 States In Support Of Texas Border Defense
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Border Fence by Dan Heaton, U.S. Air Force (DOD Photo 061003-F-1726H-004)

(Anchorage, AK) – On Monday, Alaska Attorney General Treg Taylor joined 26 other states in an Iowa and Utah-led letter to the Biden Administration, supporting...
https://alaska-native-news.com/attorney-general-treg-taylor-joins-26-states-in-support-of-texas-border-defense/72393/
#texas #border #fence #treg #taylor #support

"Here, by comprehensively mapping 3D #chromatin organization during #Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additionally, the binding sites of #Foxp3, a Treg lineage specifying #transcription factor, were highly enriched at Treg-specific chromatin loop anchors."

https://www.nature.com/articles/s41467-023-42647-y

Treg cells are a category of T cells whose properties make them a candidate for potential treatment therapies for #IBD. We eagerly await the outcome of clinical trials using this approach that are currently underway.

#crohns #crohnscolitis #crohnsandcolitis #inflammatoryboweldisease #treg #tcells #tcell

@gpollara @JExpMed

The work on the DC - quite descriptive - is published. Find it here: https://mastodon.social/@tinyspheresof/109681388538649498

The T cell work has not been published. I think I have a mostly complete manuscript that I could put on bioRXv. I'll discuss it with my former PI.
The short version: #IL6 and #TNF were very abundant, and were in the way of Treg-Teff interaction, #Teff not reacting to #Treg suppression anymore. Possibly partly explaining why drugs against these work in #arthritis.

Lilly walks away from Nektar's PEG conjugate of rhIL-2, rezpeg - aka rezpegaldesleukin, aka NKTR-358 - after disappointing phase II results in lupus.

#Immunology #immunotherapy #RegulatoryTCell #Lupus #Treg #drugdevelopment

https://www.fiercebiotech.com/biotech/after-gathering-enough-nektar-lilly-hands-backs-rights-immunology-med-post-lupus-fail

@weldeiry Nice succinct overview of CD4+ #Tcells in #cancer #immunology. Also a short paragraph on cancer promotion by (a subset of) these cells, a.o. #Treg.

Thanks for sharing.

"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."

#immunology #Treg

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183

Review at EJI

"Dysregulation or overproduction of IL-6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL-6 in altering the balance between Treg and Th17 cells, controlling IL-6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases."

#Immunology #Treg #Th17 #Autoimmunity

https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201040391

"These results identify a Notch1/CD22 signaling axis that disrupts Treg function in MIS-C and point to distinct immune checkpoints controlled by individual Treg Notch receptors that shape the inflammatory outcome in SARS-CoV-2 infection."

#COVID #COVID19 #MISC #TREG #notch

https://www.jci.org/articles/view/163235

I´m new here and would love to connect to immunologists and haematologists working on #HSCT and #GVHD #treg, anyone?
#immunology #haematology #hematology

Just arrived here. Still not sure how this works though.. #science #immunology #HSCT #treg #lymphocytes #celltherapies #immunemodulation #CMV #GVHD will all these #s help me to get content I'm keen on?

I like this intro jump from Mitchison to Sakaguchi (ref 21 to 22)

"Forty years ago, high-zone immune tolerance had been suggested to be mediated by suppressor T cells (21). The existence of suppressor T cells has long remained controversial and was not accepted until regulatory T cells (Tregs) were characterized more than 15 years later (22)."

#Immunology #Tolerance #Treg #Hemophilia