halama_immuno

@cyrilpedia An interesting question in this context is the possibility of (organ'-specific) heterogeneity of this "ticking clock"...and whether there is specific factors that induce "overclocking"... #epigenetics #Heterogeneity #tissue #TissueRepair #genomic

Gonzalo

Recently Published!

"The Effects of Low-Dose Non-ionizing and Ionizing Radiation on Wound Healing and Cancer"

link.springer.com/chapter/10.1

#Cancer #CancerResearch #WoundHealing #TissueRepair #Radiation

Thiago Carvalho

Really cool work in #Immunity by Annika Frede, Eduardo Villablanca et al. using a mouse DSS model of intestinal damage

"Although neutrophils and monocytes expanded transiently during the inflammatory process, B cells continued to expand during the recovery phase, becoming the most dominant cell type within the colon LP. Using flow cytometry, single-cell RNA sequencing (scRNA-seq), immunofluorescence, and RNAscope, we identified an interferon (IFN)-induced B cell subtype that accumulates in damaged areas of the regenerating colon. B cell depletion (BCD) during the recovery phase enhanced tissue repair and a transcriptomic program associated with the extracellular matrix (ECM) remodeling. "

#MucosalImmunology #Immunology #TissueRepair #IBD #Colitis

cell.com/immunity/fulltext/S10