#antimicrobial

SciTech Chronicles. . . . . . . . .Mar 24th, 2025

https://bit.ly/stc032425

#genes #chromosome #hippocampus #myelin #Aardvark #multimodal #GFS #democratising #cognitive #assessment #Human-AI #Collaboration #E2A #192Tbit/s #Alcatel #2028 #genomics #bioinformatics #antimicrobial

Laser-textured metal surfaces mimic shark skin to combat #bacterial #biofilms.

#biofouling #antimicrobial #ecesis #colonization

https://phys.org/news/2025-02-laser-textured-metal-surfaces-mimic.html

#AI model generates #antimicrobial #peptide structures for screening against treatment-resistant microbes

https://phys.org/news/2025-02-ai-generates-antimicrobial-peptide-screening.html

How to use wooden cooking utensils to protect you and them https://www.diningandcooking.com/1892363/how-to-use-wooden-cooking-utensils-to-protect-you-and-them/ #antimicrobial #bacteria #BerlinConsumerAdviceCentre #BZfE #ChoppingBoards #cleaning #Cooking #GermanAssociationForPersonalCareAndDetergents #germany #HealthHazards #hygiene #JudithSchryro #KitchenUtensils #Meat #Raw #Salad #wood #Wooden

Antibiotic emergency ‘could claim 40 million lives in next 25 years’

We face a growing antibiotic emergency that could have devastating impacts on men, women and children across the globe, Dame Sally Davies says.

Davies, a former chief medical officer for England,
has become a leading advocate for global action to fight the scourge of superbugs.

She told the Observer that there is a real danger that routine procedures
– from surgery to childbirth
– could carry widespread life-threatening risks
because of the spread of bacteria that possess #antimicrobial #resistance (AMR).

“About a million people die every year because of the spread of microbial resistance, and that figure will rise over the next 25 years,” she said.
“It is really scary.”

Estimates suggest that by 2050, death rates from AMRs will have doubled,
with figures indicating almost 40 million people will lose their lives to superbugs over the next 25 years,
-- with elderly people especially at risk.

“Recent data shows AMR is going down in the under-fives, which is good news.
For the over-70s, mortality rates have gone up 80% since 1990; that is very concerning.”

As the population ages, more people are living with chronic disease and that makes them more vulnerable to AMR, researchers have argued.

In the face of these threats, doctors have tried to limit prescriptions of antibiotics as much as possible
while patients have been pressed to complete courses of treatments.

However, medical misuse of antibiotics is not the only route by which resistance spreads.
The landscape itself plays a critical role,
a problem that stems from the fact that about 70% of all antibiotics are given to #livestock,
creating a pool of animals in which resistance can evolve.

“We’re essentially throwing antibiotics at cows and chickens and sheep as cheap alternatives to giving them growth promoters or prophylactics to prevent the spread of disease,” said Davies.

Such actions help microbes to evolve, so they develop the ability to ward off antibiotics, resistance that then spreads across the globe.

“If you’ve got intensive farming where a lot of antibiotics are used or a busy hospital that has a poor sewage system,
resistant bacteria can get into waterways,” added Davies.

“Winds blow over these patches of contaminated land or water and pick up bacteria and genes with resistance in them,
then let them rain down in other places.
That is how pernicious this problem has become.”

The reason AMRs spread is a simple matter of the survival of the fittest, added Davies.
“Bacteria take about 20 minutes to multiply.
They also mutate a great deal,
and if they do so in the presence of antibiotics and that mutation protects them,
these strains will multiply.
Crucially they can pass that on to any bacteria with which they make contact.”

The ease with which AMR spreads means it is becoming more and more important that we do not misuse the antibiotics we possess.
It also generates a need for new antibiotics to be developed - and again this raise problems, said Davies.

https://www.theguardian.com/society/2025/jan/05/antibiotic-emergency-could-claim-40-million-lives-in-next-25-years?CMP=Share_iOSApp_Other

@david_chisnall @davep @pussreboots @CStamp @futurebird

RE
#lazyants are the ones that spend all of their time #debugging

Funny, actually some do that

2018 #newscientist (edited)
We don’t know yet if the #ants are just cleaning the wound and removing debris, to prevent infection, or applying #antimicrobial substances with their saliva

Although #primates are known to tend to their own wounds, this is the first time an animal gives medical care to others

https://www.newscientist.com/article/2161051-ants-care-for-wounded-comrades-by-licking-their-wounds-clean/

R to @ECDC_EU: Check the latest report on #antimicrobial consumption in the EU/EEA here:

https://www.ecdc.europa.eu/en/publications-data/antimicrobial-consumption-eueea-esac-net-annual-epidemiological-report-2023

[2024-11-18 14:07 UTC]

Permafrost Thaw

The thawing of #permafrost is associated with the release of several significant components, including:

• Ancient #microorganisms that may harbour #antimicrobial resistance (AMR) genes

• Accumulated pollutants and #HeavyMetals

• #Methane, which plays a role in accelerating #ClimateChange

• Newly created #ecological niches that may support #pathogens

#PermafrostMelt #EmergingThreats

https://doi.org/10.1038/s41558-021-01162-y

4/n

New Cationic Antimicrobial Octapeptides

Tryptophan-containing members of an alternative class of antibiotics show broad-spectrum activities

https://www.chemistryviews.org/new-cationic-antimicrobial-octapeptides/

#chemistry #chemistryviews #chemviews #chemiverse #research #medicinalchemisistry #antimicrobial

‘Rivers you think are pristine are not’: how drug pollution flooded England’s national parks – and put human health at risk - https://www.theguardian.com/environment/2024/sep/27/amr-drug-resistance-england-national-parks-hidden-hazards-rivers-pollution-aoe "High levels of antibiotics and other drugs have been found in water in the country’s most treasured and protected landscapes, raising concerns over #antimicrobial resistance" we are so stupid...

New 2030 #Target Adopted!

Political Declaration of the UN High-level Meeting on #AntimicrobialResistance

"We, Heads of State and Government ...

Note with concern that ... in 2019, 4.95 million #deaths were associated with drugresistant bacterial infections, including 1.27 million deaths directly attributable to bacterial #antimicrobial #resistance, 20 per cent of whom were #children under five ...

1/2
#GlobalHealth #GlobalGoals #SDGs #SDG3 #2030Agenda #UN #AntimicrobialResistance #AMR

#Global #burden of #bacterial #antimicrobial #resistance 1990–2021: a systematic analysis with #forecasts to 2050, Lancet: https://www.sciencedirect.com/science/article/pii/S0140673624018671?dgcid=rss_sd_all

Our forecasts show that an estimated 1·91 million (1·56–2·26) deaths attributable to AMR and 8·22 million (6·85–9·65) deaths associated with AMR could occur globally in 2050. Super-regions with the highest all-age AMR mortality rate in 2050 are forecasted to be south Asia and Latin America and the Caribbean.

Pipeline release! nf-core/funcscan v2.0.0 - v2.0.0 - Brazilian Escondidinho - 2024-09-05!

Please see the changelog: https://github.com/nf-core/funcscan/releases/tag/2.0.0

#amp #amr #antibiotic-resistance #antimicrobial-peptides #antimicrobial-resistance-genes #arg #assembly #bgc #biosynthetic-gene-clusters #contigs #function #metagenomics #natural-products #screening #secondary-metabolites #nfcore #openscience #nextflow #bioinformatics

The #animals we eat could be the gateway for a #pandemic in form of #antimicrobial resistance; drug-resistant #diseases could cause 10 million deaths each year by 2050 if the world runs out of #antibiotics to treat infections… https://www.rmit.edu.au/news/all-news/2024/august/food-animal-pandemic #superbugs #livestock (1/2)

#Formaldehyde And Formaldehyde-Releasing Preservatives

Formaldehyde and formaldehyde-releasing preservatives (#FRPs) are used in many #PersonalCare products, particularly in #shampoos and liquid #BabySoaps.

"These preservatives release small amounts of formaldehyde over time. Since low levels of formaldehyde can cause health concerns-at levels as low as 250 parts per million and even lower levels in sensitized individuals-the slow release of small amounts of formaldehyde are cause for concern. A 2015 study determined that longer storage time and higher temperature increase the amount of formaldehyde released from FRPs and could ultimately lead to more severe health concerns.

"#Quaternium15 is the most sensitizing of these FRPs and is found in #blush, #mascara, #lotion and #shampoo.

"#DMDMHydantoin is found in lotion, #sunscreen and make-up remover and is one of the least sensitizing of the FRPs.

"#ImidazolidinylUrea, #DiazolidinylUrea, and #polyoxymethylene urea, are found in shampoo, conditioner, blush, #EyeShadow, and lotion and are all known human #allergens. #Imidazolidinyl urea is one of the most common #antimicrobial agents used in personal care products and is often combined with #parabens to provide a broad spectrum preservative system. #Diazolidinyl urea releases the most formaldehyde of any FRP.

"Sodium #hydroxymethylglycinate is found in shampoo, moisturizer, conditioner, and lotion. Animal studies have shown that sodium hydroxymethylglycinate has the potential for sensitization and #dermatitis.

"#Bromopol is found in #Nail Polish, #makeup remover, #moisturizer and #BodyWash. Bromopol is considered safe in concentrations less than 0.1%, but cannot be found in formulations with the FRP amine. Mixing bromopol and amines produce #nitrosamines which have been found to penetrate the skin and cause #cancer.

"#Glyoxal is found in conditioner, lotion, nail polish and nail treatment. CIR Expert Panel has declared that glyoxal is a skin allergen.

Regulations

"Banned from use in #cosmetics and #toiletries in #Japan and #Sweden; in the #EU, restricted in personal care products, and labeling is required in products that do contain these chemicals; concentration restrictions in Canada. The EU allows the use of Quaternium-15 up to 0.2% as a preservative in cosmetic products.

How to Avoid?

Read labels and avoid products containing the following ingredients: Formaldehyde, quaternium-15, dimethyl-dimethyl (DMDM) hydantoin, imidazolidinyl urea, diazolidinyl urea, sodium hydroxymethylglycinate, 2-bromo-2-nitropropane-1,3-diol (bromopol). In addition, choose nail products that are labeled formaldehyde-free or “toxic-trio-free” (formaldehyde, toluene and DBP). Skip hair-smoothing products—especially those sold in salons, as salon-based products are exempt from labeling laws. Don’t use expired cosmetic products or store cosmetic products in the sun because this can cause more formaldehyde to be released."

https://www.safecosmetics.org/chemicals/formaldehyde/

#Chemicals #ReadTheLabels #Consumerism #ToxicChemicals #PersonalCareProducts #Pollution

#E_coli variant may cause #antimicrobial resistance in #dogs, #humans.

#genomics #antibiotics #membrane_pore

https://phys.org/news/2024-07-coli-variant-antimicrobial-resistance-dogs.html

Molecular de-extinction uses #AI to revive #antimicrobial peptides from extinct organisms. A study analyzed 10 million peptides, identifying 37,000 with potential antimicrobial activity. 69 were synthesized and tested, confirming efficacy against bacterial pathogens. This technique could accelerate discovery of new therapeutic molecules against antibiotic resistance.

https://www.nature.com/articles/s41551-024-01201-x

#DeExtinction #AntibioticResistance #Research

Study finds #antimicrobial resistance in #soils Scotland-wide

#microbiome #amr

https://phys.org/news/2024-05-antimicrobial-resistance-soils-scotland-wide.html

#Antimicrobial #peptide from #cows shows potential for treating hypervirulent #bacteria.

#Klebsiella #Polyproline_peptide

https://phys.org/news/2024-05-antimicrobial-peptide-cows-potential-hypervirulent.html

#Pomegranate power: Unlocking sustainable #antimicrobial solutions from peels.

#antibiofilm #phenolics

https://phys.org/news/2024-04-pomegranate-power-sustainable-antimicrobial-solutions.html