PLOS Biology

Slow amplitude fluctuations in sounds, critical for #SpeechRecognition, seem poorly represented in the #brainstem. This study shows that overlooked intricacies of #SpikeTiming represent these fluctuations, reconciling low-level neural processing with #perception @plosbiology.org 🧪 plos.io/3FJ4adI

Rhyothemis

Finding a Master Immune System Controller

'In a series of groundbreaking, elegant experiments ... a team led by Howard Hughes Medical Institute Investigator Charles Zuker has found that one controller of the immune system actually lies elsewhere—in the brain. The researchers showed that a group of nerve cells in the brainstem acts like a master controller or rheostat, sending and receiving signals from vagal neurons in the body to either boost inflammation or dial it down. '
...
'The first big question for Zuker’s group, therefore, was whether the brain really does respond to signals from the immune system. To find out, his team injected mice with a known immune stimulant, lipopolysaccharide, then searched the mouse brain to see if any specific areas were being activated by the signal. The quest was like “looking for a needle in a haystack,” says Medzhitov. But it worked. The researchers pinpointed an area of the brainstem called the caudal nucleus of the solitary tract. That was “extraordinarily exciting,” recalls Hao Jin, a postdoctoral fellow in Zuker’s lab who led these studies. Previous work by Zuker’s team had shown that this area of the brain received other body-brain signals up the vagus nerve highway. '

hhmi.org/news/finding-master-i

#immunology #neuroscience
#inflammation #VagusNerve #brainstem

Finding a Master Immune System Controller | HHMI

New research shows that a region of the brain can ramp…

www.hhmi.org
Scientific Frontline

Newly discovered group of #neurons in the #brainstem which receives information directly from the basal ganglia and controls the right-left circuit,” Eventually, this discovery may be able to help people suffering from #Parkinson’s disease.
#Neuroscience # Brain #sflorg
sflorg.com/2024/02/ns02222401.

katch wreck

"Together, these findings suggest that #seizure activity in a focal subregion of the #amygdala is sufficient to suppress breathing and air hunger for prolonged periods of time in the #postictal period, likely via #brainstem and insula sites involved in #chemosensation and #interoception."

insight.jci.org/articles/view/

JCI Insight - Failure to breathe persists without air hunger or alarm following amygdala seizures

insight.jci.org
PLOS Biology

New insights into how hippocampal #MemoryFormation & recall is controlled by a disinhibition-based mechanism, supported by #hippocampal #somatostatin interneurons & their pontine #brainstem inputs from the #NucleusIncertus #PLOSBiology plos.io/3NkleaD

Deepthi Mahishi

Hi Mastodon! Another migrating neurobiologist here - I’m a sensory neuroscience postdoc at Cornell University working on optimizing functional imaging of #brainstem circuits using #multiphoton #microscopy in awake, behaving mice.
Looking forward to the new chapter here!