#DeepMutationalScanning

Pacybara: Accurate long-read sequencing for barcoded mutagenized allelic libraries.
Our pre-print is now available: https://www.biorxiv.org/content/10.1101/2023.02.22.529427v1

@fritzroth
#pacbio #Bioinformatics #DeepMutationalScanning #BarSeq #VariantEffectMapping #longread #mave

I figure I should also make an introduction. I'm an RA in the Roth Lab at UofT and I work on Multiplexed Assays of Variant Effects and their use toward clinical variant interpretation. #variantclassification #deepmutationalscanning #bioinformatics #systemsbiology #computationalbiology #moleculargenetics

#introduction
Hi, I am Matthew and currently work on #ovarian #cancer with a focus on therapy predictive mutations, genomic scarring biomarkers, and mechanisms of resistance to #PARP inhibitors.
Currently this is involving lots of #FunctionalGenomics with #MAVE assays and #DMS (#DeepMutationalScanning) to dissect protein complex interactions with inhibitors.
I mainly do #ComputationalBiology and supervise a team that does the wet work.
Trying to create a focused work engagement in this account