#enzymes

10-Apr-2025
#Venom characteristics of a deadly #snake can be predicted from local #climate
In dryer regions of #India, the venom of Russell’s #vipers contains more #protein-degrading #enzymes

https://www.eurekalert.org/news-releases/1079835 #science #medicine #TropicalDisease

Scientists uncover how enzymes evolved to function at low temperatures

https://phys.org/news/2025-03-scientists-uncover-enzymes-evolved-function.html

#biology #science #enzymes #molbio #omics

Les enzymes du cycle de Krebs sont fondamentales :
Citrate synthase
Aconitase
Isocitratelyase
Chacune joue un rôle spécifique. Une déficience peut avoir des conséquences graves.
Pourquoi ces enzymes sont-elles si importantes ? Expliquez-nous dans les commentaires.
#biochimie #enzymes #science

#Enzymes are the engines of life − #machine_learning tools could help scientists design new ones to tackle #disease and #climate_change.

#AI #directed_evolution #bioengineering

https://theconversation.com/enzymes-are-the-engines-of-life-machine-learning-tools-could-help-scientists-design-new-ones-to-tackle-disease-and-climate-change-249565

From 14 Feb: AI used to design a multi-step enzyme that can digest some plastics - Enzyme mechanisms can be complex, and getting them to wor... https://arstechnica.com/science/2025/02/using-ai-to-design-proteins-is-now-easy-making-enzymes-remains-hard/ #ai #biochemistry #biology #catalysts #chemistry #computer-science #enzymes #science

SciTech Chronicles. . . . . . . . .Feb 14th, 2025

https://bit.ly/stc021425

#perovskite #water first-generation #end-of-life #Titan #dissipation #rotation #circular #influenza #vaccine #H1N1 #H3N2 #proteins #enzymes #structure #RFdiffusion #buried #extremophiles #subglacial #hydrothermal

In the hunt for new and better #enzymes, #AI steps to the fore

https://phys.org/news/2025-01-enzymes-ai-fore.html

Ulschan Bathe and her team are accelerating plant evolution to address #FoodSecurity challenges. By optimizing #enzymes through directed evolution, they aim to increase #CropYields efficiently and sustainably: http://go.tum.de/331754

#SustainableAgriculture
S. Kissel

Engineered enzymes may help plants adapt to higher temperatures

https://phys.org/news/2024-12-enzymes-higher-temperatures.html

#plants #biotech #molbio #proteins #enzymes #research

Join the FREE livestream of the first STRENDA/ESAB Symposium on “The Need for Reproducibility of Enzyme Reaction Data” at the Lodz University of Technology, Poland , on November 14, 2024.

The symposium will be chaired by Roland Wohlgemuth from the Lodz University of Technology and Carsten Kettner from the Beilstein-Institut.

https://attendee.gotowebinar.com/register/5877445346982512472?M=y

#STRENDA #enzymes #enzymology

12-JUL-2024
A better way to make #RNA drugs
New enzymatic synthesis method developed at Wyss Institute expands RNA therapeutic capabilities while eliminating toxic byproducts of standard chemical synthesis

https://www.eurekalert.org/news-releases/1050967 #science #nanoworld #enzymes

"We find that #purine synthesis constitutes a bottleneck for metabolic expansion, which can be alleviated by non-autocatalytic phosphoryl coupling agents. Early phases of the expansion are enriched with #enzymes that are metal dependent and structurally symmetric, supporting models of early #biochemical #evolution. This expansion trajectory suggests distinct hypotheses regarding the tempo, mode and timing of metabolic pathway evolution"

https://www.nature.com/articles/s41559-024-02361-4

A research team led by the University of California, Irvine has discovered the key role that the #APOBEC3A and #APOBEC3B #enzymes play in driving #cancer mutations by modifying the #DNA in #tumor #genomes, offering potential new targets for intervention strategies.
#Biology #Biochemistry #Genetics #sflorg
https://www.sflorg.com/2024/03/bio03182402.html

These findings provide the first direct evidence that RGL, previously known from gene expression and in-vitro studies, actively contributes to fruit softening by cleaving pectin in the cell walls of ripe fruits. (7/7)

https://botany.fyi/aS8CnE

#FruitRipening #Enzymes

#Geraniol Pharmacokinetics, #Bioavailability and Its Multiple Effects on the #Liver Antioxidant and Xenobiotic-Metabolizing #Enzymes

https://www.frontiersin.org/articles/10.3389/fphar.2018.00018/full

#openaccess

https://knowablemagazine.org/content/article/food-environment/2023/how-to-recycle-plastic-with-enzymes

#Recycle #Plastic #Enzymes #Food #Environment

“…with #plastic production doubling every 15 years. The relatively low cost of #petroleum based polymers encourages their single use and #overconsumption. Synthetic plastics are recalcitrant to #biodegradation, and #mismanagement of plastic waste leads to their accumulation in the #ecosystem, resulting in a disastrous #environmentalfootprint.

https://www.annualreviews.org/doi/10.1146/annurev-chembioeng-092120-091054

"We examined how these #flavonoids are #oxidized by human #P450 family 1 and 2A #enzymes. Naringenin was principally oxidized at the 3′-position to form eriodictyol by CYP1 enzymes more efficiently than by CYP2A enzymes, and the resulting eriodictyol was further oxidized to two penta-hydroxylated products. In contrast to plant P450 enzymes, these human P450s did not mediate the desaturation of naringenin and eriodictyol to give apigenin and luteolin, respectively."

https://pubs.acs.org/doi/10.1021/acs.chemrestox.3c00229

New algorithm finds lots of #gene_editing #enzymes in environmental #DNA

#eDNA #CRISPR #genomics #prokaryotes #FLSHclust #RNA

https://arstechnica.com/science/2023/12/new-algorithm-finds-lots-of-gene-editing-enzymes-in-environmental-dna/

Mysteries in DNA
Enzymes cut through the unknown
Secrets revealed anew

#dna #enzymes #mystery #geneediting #haiku #poetry

https://arstechnica.com/science/2023/12/new-algorithm-finds-lots-of-gene-editing-enzymes-in-environmental-dna/

Evaluating the success of #biocatalysis from pharmaceuticals to environmental technology.

#enzymes

https://phys.org/news/2023-11-success-biocatalysis-pharmaceuticals-environmental-technology.html