These are public posts tagged with #hippocampus. You can interact with them if you have an account anywhere in the fediverse.
@johnwidloski and I are co-organizing a symposium on #HippocampalReplay at the #EBBS25 in Bordeaux!
Our goal: From the state of the art in awake replay models & existing data, determine the next big questions and most informative future experiments to finally figure out what is awake replay for!
Our speakers:
John Widloski
Lisa Genzel
Jacob Bakermans
Elisa Massi
Meeting dates: 28 June to 1 July 2025 (our symposium is on the last day
Programme: https://ebbs2025.azuleon.org/programme
The abstract submission deadline for posters (and early bird registration) is on 31 March 2025 - I hope to see you there!
The website of the 51st EBBS Meeting :: EBBS 2025
ebbs2025.azuleon.orgHippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study 13.01.25
#LongCovid #MECFS #hippocampus
Link to plos.org:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316625
Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue…
journals.plos.orgSciTech Chronicles. . . . . . . . . . . . . . . . . . . . .Jan 22, 2025
#Neuromorphic #semiconductor #self-learning #memristor-based #Moon #LuGRE #GNSS #navigation #polycatenated #three-dimensional #chain-mail #PAM #neurons #mechanical #stretch #metabolism #vagus #neurons #memory #electrode #amygdala #hippocampus
@mick
Cool stuff, congrats!!
Were there no connections between Nucleus Reuniens and Dentate Gyrus or CA3?
I also wonder what you think of this commentary on Ito et al., 2015, by Blake Porter: https://www.blakeporterneuro.com/writing/science-writing/commentary/ito_et_al_2015_commentary/
#Hippocampus #PrefrontalCortex #NucleusReuniens #Neuroscience
Look what "Santa" brought me - lots to read for 2025!
#Neuroscience #TheHippocampusBook (2nd edition) #Hippocampus
re: Sad News for Neuroscience
A loss for the field! Her work was so critically important. (Her work on the effect of hippocampal lesions on imagination was a key factor in our thinking about the role of #hippocampus in planning.) I always found myself thinking about new perspectives after talking to her. She will be missed.
Sad News for Neuroscience
I just learned that the incredible neuroscientist Eleanor Maguire died a few days ago, on January 4th. Such a sad news...
Her friends have set up an online memorial page: https://www.online-tribute.com/EleanorMaguire
My former mentor Hugo Spiers was her first postdoc and posted about this on Linkedin: https://www.linkedin.com/posts/hugo-spiers-66b17124_devastating-news-that-eleanor-maguire-has-activity-7282334041637306368-3K8s?
Here is a nice interview of her, it is not recent but definitely gives you an idea of what a nice person and great scientist she was: https://www.cell.com/current-biology/fulltext/S0960-9822(12)01190-6
#neuroscience #hippocampus #historyOfScience
It looks like the hippocampal special issue on "Scientific Histories of Hippocampal Research" is fully out. These are fantastic. I recommend reading them all!
@nina_kali_nina yeah, the US visa process is very weird. Last time I'd applied to travel for a #neuroscience conference, they asked for all my social media handles from like last 5 years (even the deleted ones iirc) - this included Reddit where most people create accounts that allow them to stay at least pseudonymous. Talk about invasion of privacy!
On arrival, I had a funny interaction with the immigration officer who asked me about my work. I mentioned that I study this part of the brain called the #hippocampus and different brain rhythms. He seemed really fascinated and I remember his next question very distinctly (which he asked with a big smile):
"So, are you pro-hippocampus or anti?"
I chuckled and said, "oh, very pro-hippocampus"
[sorry, didn't mean to distract from the message in the OP, just that it reminded me of this interaction]
Andrew Wikenheiser looked at awake vs sleep replay when he was in my lab and found sleep was more forward than awake, though the effect was subtle (as neuroscience effects often are). #hippocampus
A. M. Wikenheiser, A. D. Redish (2013) “The balance of forward and backward hippocampal sequences shifts across behavioral states” Hippocampus 23:22-29.
Attention-Worthy Links for December 17th, 2024
#warming #global #accelerating #Copernicus #NOAA #1.6°C #ACES #bridges. #barracks #barriers #culverts #3D-Print #concrete #vaults #pre-eclampsia #mRNA #VEGF #Endocannabinoids #ABHD6 #hippocampus #waves #spindles #ripples #consolidation #dementia #Alzheimer's
A short commentary by the great Anna Gillespie on awake replay:
Ruminating on replay during the awake state
#GillespieLab (https://www.gillespie-lab.com/)
Interesting bits:
"replay during sleep is generally thought to occur in the forward direction"
I believe this is true too, but has anyone actually analyzed it? It could be done on several existing datasets...
"The idea that awake replay might serve a planning role was broadly adopted by the field, even though direct experimental evidence [...] has been slow to emerge"
YES because replay is not related to immediate planning, however nice it would be if it was
"We, as a field, also need to be more precise with our terminology. For instance, what exactly should we consider evidence of ‘planning’ or ‘deliberation’ in an animal model? "
YES
Related: history of the 'genesis' of #ThetaSequences narrated in this retrospective by @adredish: Mental Time Travel: A Retrospective
(original post:
https://neuromatch.social/@adredish/113662497894186335) #RedishLab
I'd actually argue that replay, and not theta sequences, might be closer to mental time-travel... but we probably don't know enough about either to be sure yet!
#Hippocampus is publishing a series of #science retrospectives about the history and journeys that led us to where we are scientifically.
Mine just dropped.
http://dx.doi.org/10.1002/hipo.23661
I'm deeply honored to have been asked to be a part of this. (They are releasing them as they get through production, so keep an eye on the journal for the rest of them. They had us read them to make connections and it's a fantastic set.)
Yes, the effect of reward on replay is more nuanced. There are changes in rate across the waiting period and one needs to take into account these changes to see effects.
My memory is that the Ambrose paper only looked at rewarded vs non-reward, which doesn't get at the real issue (which is value and changes in value).
Take a look at B. Schmidt, A. D. Redish (2021) “Disrupting the medial prefrontal cortex with DREADDs alters hippocampal sharp-wave ripples and their associated cognitive processes” Hippocampus. 31(10):1051-1067.https://onlinelibrary.wiley.com/doi/10.1002/hipo.23367 for a more nuanced story.
I keep seeing studies (especially computational ones) citing the Ambrose et al. 2016 paper as proof that #HippocampalReplay is modulated by reward.
I don't think this result can be trusted...
The time spent at low-speed at reward sites wasn't controlled. Rats left the less rewarded sites much faster, and would probably move a lot more when less reward was present (not analyzed I think).
The amount of ripples or replay is analysed in count per second. I believe this means seconds of any kind of behaviour, not just rest or low speed. But #Ripples and the related #Replay only happens when the rat is quasi-immobile. At low speed you might have 1 replay per second, while when moving it will be 0/s.
A recent preprint (Mallory et al., 2024) suggests that after a few seconds at a reward location, reverse replay dominates. Ambrose et al. specifically show an increase of reverse replay for the x4 reward vs x1 reward. If rats indeed spent more time at the most rewarded location, they would be in reverse replay mode, fully explaining the results without the need to invoke any kind of value processing. Note: the reduced replay result was not specific to reverse replay for 1 vs 0, probably because the rats didn't stay immobile long enough to get some of those forward replays during the earlier reward period.
I might have missed something (if so let me know) but I am now completely unconvinced by the 2016 paper. What do you all think?
#Hippocampus #ValueCoding
Edit: added some more info after re-reading the 2016 paper
Some #Hippocampus (the original) seen at SeaLife Loch Lomond
A few more animals below
1/3
My latest #Neuroesc #JournalClub was on this:
Rat anterior cingulate neurons responsive to rule or strategy changes are modulated by the hippocampal theta rhythm and sharp-wave ripples
I won't do a super-long summary like last time, but please share your thoughts if you've read it!
The author line-up is quite interesting, I think they were all students at the time of data collection which seems to have happened a long time ago, and now many are PIs (@BenoitGirard probably knows about the backstory...)! Probably a pandemic paper??
The scientific question (what supports rule recognition and strategy shift) is really interesting, and they record in the frontal cortex (#ACC) as well as #Hippocampus (ventral CA1!), but the rats just were not up to the task (1/5 rats actually did what they wanted). I am also not fully convinced by some of the analysis. @jessetm I'd be interested to know what you think of their strategy detection method!
Why is it that all papers looking at these themes always end up being.. quite complex??
Have you ever wondered how memories are processed downstream of the #hippocampus and how this is affected by #Alzheimer's? We believe we may find some answers by riding all the way down the fornix to the mammillary body. Apply here for a #PhD with us: https://ovgu.b-ite.careers/56yvk