#hippocampus

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Albert Cardona

From the lab of Helene Schmidt:

"Large-scale 3D EM connectomics dataset of mouse hippocampal area CA1", Corteze et al. 2025
biorxiv.org/content/10.1101/20

Spectacular.

#neuroscience #hippocampus #mouse

Apr 09, 2025, 14:48 · · 1 · 0
El Duvelle Neuro

I keep going back to this question about #TemporalCreditAssignment and #HippocampalReplay:
As an "agent" you want to learn the value of places and which places are likely to lead to reward;

-1) if a place leads to higher than expected reward, you'll want to propagate back the reward info from the reward throughout the places that led to the reward. If replay does that you should see an increase of replay at a new reward site and the replay sequences should start at the reward and reflect what you just did to reach it. Right?

-2) if a place leads to lower than expected reward, you'll also want to propagate that lowered value, pretty much in the same way, so if replay does that you should see a similar replay rate and content for increased OR decreased reward sites. Right?

-3) if a place has had unchanged reward for a while and you're just in exploitation mode (just going there again and again because you know that's the best place to go to in the environment) then you shouldn't need to update anything and replay rate should be quite low at that unchanged reward side. Right?

That's not at all what replay is doing IRL, so does that mean replay is not used for temporal credit assignment? Or did I (very likely) miss something?

#Neuroscience #ComputationalNeuroscience #DecisionMaking #Hippocampus

Apr 04, 2025, 14:03 · · 0 · 0
PLOS Biology

Are hippocampal representations of other people anchored to #SelfKnowledge? This study shows other people’s preferences are represented relative to personal preferences in the #hippocampus & dorsomedial prefrontal cortex when retrieving relational social knowledge @PLOSBiology plos.io/449XRcD

Egocentric anchoring-and-adjustment in the hippocampal formation. Top: Neural and behavioral representational dissimilarity matrices (RDMs) for the general linear model (GLM) searchlight analysis for one representative participant. The neural RDM was used as a dependent variable with six predictor behavioral variables. These six variables were the absolute distance between the stranger’s rating and the ratings of the groups that are being compared with the stranger (absolute distance, AD), the differences between self and others’ preferences (rating discrepancy, RD, with either groups or individuals), the cognitive demand of how far the stranger’s preference is away from the individual’s rating (rescaling), and the memory for self and others’ preferences (rating consistency, RC, for groups or individuals). Middle: Group activation maps for self vs. group rating discrepancy (RDgroup). Bottom right: Beta coefficients of RSA GLM in ROI of dmPFC. Bars showing beta coefficients resulting from the GLM for each behavioral variable in the dmPFC, where there is a significant dmPFC effect for RDgroup (t(19) = 2.92, p = 0.008). Each dot represents an individual participant.
Apr 04, 2025, 07:20 · · 0 · 0
El Duvelle Neuro

#PlaceCells often have elongated place fields next to an environment's boundaries.
Is there any paper where this phenomenon is directly predicted by the #SuccessorRepresentation model of place cells?

#SpatialCognition #Neuroscience #Hippocampus

Mar 27, 2025, 17:12 · · 2 · 0
El Duvelle Neuro

Thinking about #PlaceCells and the #Hippocampus, do you think results in rats (/rodents) generalise well to humans, and conversely?

#Neuroscience #NeuroRat #NeuroHuman

· 16 people · Closed
Mar 21, 2025, 10:50 · · 4 · 0
katch wreck

"In mice, here we reveal a non-pyramidal excitatory neuron type — the “ovoid” neuron — that is spatially adjacent to subiculum pyramidal cells but differs in gene expression, electrophysiology, morphology, and connectivity. Functionally, novel object encounters drive sustained ovoid neuron activity, whereas familiar objects fail to drive activity even months after single-trial learning."

nature.com/articles/s41467-025

#ovoid #neuron #memory #hippocampus

Atypical hippocampal excitatory neurons express and govern object memory - Nature Communications

Pyramidal cells are classically thought to comprise…

Nature
Feb 12, 2025, 14:25 · · 0 · 0
knizer

Today #Bandcamp Friday supports #LA fire recovery

90 song 'today only' compilation:
goodmusiccomp.bandcamp.com/alb

Featuring tracks by: #PerfumeGenius
#KFlay
#REM
#FayeWebster
#Dawes
#DeathCabforCutie #PostalService
#MacDeMarco
#NekoCase
#TVOnTheRadio
#Blondshell
#JeffTweedy
#TheWaronDrugs
#ToroyMoi
#TenaciousD
#ModestMouse
#LittleDragon
#LALOM
#MJLenderman
#CourtneyBarnett
#RealEstate
#MyMorningJacket
#HurrayForTheRiffRaff
#JasonIsbellandThe400Unit
#SoccerMommy
#AnimalCollective
#ColdWarKids
#RickyMontgomery
#Lucius
#TheMidnight
#SpiritualCramp
#KingGizzardAndTheLizardWizard
#MadiDiaz
#Interpol
#MilitarieGun
#ChelseaWolfe
#iRo
#DirtyProjectorsAndStargaze
#PUP
#Porches
#AnnieDiRusso
#HippoCampus
#NewPornographers
#TySegall
#NealFrancis
#MikiRatsula
#Dr.Dog
#TheDip
#LocalNatives
#TundeAdebimpe
#Gustaf
#WaterFromYourEyes
#Mudhoney
#Centro
#SilversunPickups
#RYX
#ManchesterOrchestra
#PoolKids
#FIDLAR
#TheArmed
#HEALTH
#Momma
#SYML
#MiyaFolick
#JoshRitter
#TheHeavyHeavy
#Pachyman
#NickThune
#SoulAsylum
#HotlineTNT
#BEL
#Sycco
#TheHoldSteady
#cumgirl8
#RichyMitchAndTheCoalMiners
#CunninghamBird
#LalaLala
#TheoKatzman
#CassandraJenkins
#brotherkenzie
#ImWithHer
#ChrisCohen
#FlockofDimes
#Friko
#GeorgeAlice
#ThisIsLorelei
#ShannonLay
#Eggy
#AlyciaLang
#JamesHenryJr
#WatkinsFamilyHour

#BandcampFriday

Feb 07, 2025, 15:15 · · · 2 · 0
This Is My Glasgow

One of the Clyde Street entrances to the Briggait in Glasgow. Designed by Clarke and Bell, it was oginally built in 1873 as a fish market. The hippocampi on either side of the central parapet are amongst the most distinctive architectural sculptures in the city.

#glasgow #architecture #hippocampus #briggait #architecturephotography #sculpture #glasgowbuildings

An ornate entrance to a former fish market topped by a pediment with the hippocapmus sculptures on it.
Feb 06, 2025, 10:39 · · · 5 · 0
El Duvelle Neuro

This paper ⬆️ from Caitlin Mallory is now out in Science! Great to see a #HippocampalReplay paper there, and very well deserved!

The time course and organization of hippocampal replay
From #FosterLab, maybe soon the #MalloryLab??

#Hippocampus #NeuroRat

Feb 03, 2025, 12:01 · · 2 · 0
El Duvelle Neuro

@johnwidloski and I are co-organizing a symposium on #HippocampalReplay at the #EBBS25 in Bordeaux!

Our goal: From the state of the art in awake replay models & existing data, determine the next big questions and most informative future experiments to finally figure out what is awake replay for!

Our speakers:

John Widloski
Lisa Genzel
Jacob Bakermans
Elisa Massi

Meeting dates: 28 June to 1 July 2025 (our symposium is on the last day

Programme: ebbs2025.azuleon.org/programme

The abstract submission deadline for posters (and early bird registration) is on 31 March 2025 - I hope to see you there!

#Neuroscience #NeuroSymp #NeuroConf #Hippocampus

EBBS 2025 :: Programme

The website of the 51st EBBS Meeting :: EBBS 2025

ebbs2025.azuleon.org
Jan 28, 2025, 18:12 · · 4 · 0
Coach Pāṇini ®

@soc_i_ety

You #PointAndLaugh.

#Laughter is indelible in the #hippocampus.

Christine Blasey Ford told us so.

Jan 26, 2025, 15:31 · · · 1 · 0

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