#inflammasome

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

Cambridge Scientists Uncover New Way in Which Fasting Helps Reduce Inflammation
https://scitechdaily.com/cambridge-scientists-uncover-new-way-in-which-fasting-helps-reduce-inflammation/ #health #diet #fasting #inflammation #ArachidonicAcid #inflammasome #CalorieRestriction

'Here, we show that Arachidonic Acid inhibits the NLRP3 inflammasome, through a PLC-JNK-dependent mechanism, to supress IL-1β production under physiological conditions. This provides a mechanistic basis for how dietary manipulation such as fasting influences the inflammatory state and is likely to be critical for reducing the metaflammation underpinning many diseases induced by the Western Diet.'
#Immunology #Inflammation #inflammasome #Metabolism

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00028-7

"Inflammasome-mediated caspase-1 activation facilitates innate immune control of Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria. However, caspase-1 processing occurs incompletely in both mouse and human hepatocytes and precludes the generation of mature IL-1β or IL-18, unlike in other cells. Why this is so or how it impacts Plasmodium control in the liver has remained unknown."
#Malaria #inflammasome

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300440/266573/Inherently-Reduced-Expression-of-ASC-Restricts?redirectedFrom=fulltext

`Through unbiased analyses of #RNA and protein profiles in #Inositol polyphosphate-5-phosphatase D (INPP5D) -disrupted iPSC-derived human #microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted #autophagy and #inflammasome activation.. findings provide insights into the molecular mechanisms underlying microglia-mediated processes in #AD and highlight the inflammasome as a potential #therapeutic target`

https://www.nature.com/articles/s41467-023-42819-w

#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481

'Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung #inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action of GF remain unknown. In this study, we identified mitochondrial Src family kinases (mSFKs) as key determinants of GF-induced #NLRP3 #inflammasome activation.'

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200611/238968/The-NLRP3-Inflammasome-Works-as-a-Sensor-for?redirectedFrom=fulltext

How the inflammasome is activated. Almost poetic seeing it in step-wise motion here...

Cryo-EM structures of the active NLRP3 inflammasome disc - https://www.nature.com/articles/s41586-022-05570-8?WT.ec_id=NATURE-20230119&utm_source=nature_etoc&utm_medium=email&utm_campaign=20230119&sap-outbound-id=1540E81EA8A2575BEBC0E3AB32A3412AEAC13A1D

#immunology #cells '#academia #Science #IL1 #inflammasome #infection #cellular #EM

RT @CancerDoc: #NLRP3 #inflammasome is a double-edged sword in #cancer. NLRP3 activation can be associated with hyper-progression on #PD1 #immunotherapy https://www.science.org/doi/abs/10.1126/scitranslmed.abq7019
#oncology

Congratulations my friend at the Australian National University Professor Si Ming Man just awarded recipient of the 2022 Frank Fenner Prize for Life Scientist of the Year at the PM prize in Australia for his work on #inflammasome and #bacteria infection. Very well deserved for his groundbreaking work and wonderful recipient. https://www.facebook.com/IndustryGovAu/

Hi Mastodon community, here’s my #introduction I’m a #gastroenterology researcher at #UCL growing #IBD #organoids to investigate #inflammasome regulation and #autophagy

Hi Mastodon community, here’s my #introduction I’m a #gastroenterology researcher at #UCL growing #IBD #organoids to investigate #inflammasome regulation and #autophagy