#ligand

SciTech Chronicles. . . . . . . . .Mar 5th, 2025

https://bit.ly/stc030525

#cornea #epithelial #transplantation #18-months #sunspot #earthquake #Prediction #tectonic #hydrosilylation #platinum #silicon #ligand #AI #entanglement #communication #photons #LiDAR #Autonomous #Farming #odometry

New, and promising, #SurfDock diffusion generative model for #protein-#ligand #docking
https://www.biorxiv.org/content/10.1101/2023.12.13.571408v2.full.pdf+html

Unfortunately, code will only be available after the paper has been published
https://github.com/CAODH/SurfDock

We used #STRINGdb to build a zebrafish-specific ligand-receptor interactome database. We also added human interactions from IID database from Jurisica group #ligand #receptor 12/n

A nice new #paper where I have played a small part. An extremely surprising finding where mutants in the 5S #ribosomal #RNA #transcription factor #GTF3A causes enhanced #susceptibility to #HSV #virus #infection, leading to #encephalitis. A #pseudogene #transcribed is a #ligand activating #RIG-I.

https://pubmed.ncbi.nlm.nih.gov/36399538/

#fediscience #immunology #science #PID #genetics #signaling #herpes #health

Just joined and testing this new platform, time for an #introduction!

We are a #biochemistry and #structuralbiology laboratory based in #Pavia, #Italy.

#wemakeproteins and are fascinated by the #extracellular space: we study how #collagen contributes to the assembly of the #ECM and we perform #drugdiscovery studies on #enzymes of collagen #biosynthesis, plus we investigate various #ligand - #receptor #interactions leading to #signaling in humans and in insects.

Always open to #collaboration.

Check our website and help us grow: http://fornerislab.unipv.it/armenise_lab/

Nice paper from the Schapira lab identifying potential #ligand binding pockets for future #PROTAC development.

https://www.sciencedirect.com/science/article/pii/S2001037022005049#b0040

I'd like to join in on some conversations so here are some #hashtags #TPD #targetedproteindegradation #PROTAC #PROTACs #degraders #chemicalbiology #biochem #cellbiology #biotech #biopharma #ligase #ubiquitin #proteasome #ligand #labhumor #chemistry #biology #proteome #proteins #drug #pharma #startup

RASPD+: Fast Protein-Ligand #Binding #Free #Energy #Prediction Using Simplified Physicochemical Features | #ligand #modeling #molecularmodeling #protein #RASPD https://chemrxiv.org/articles/preprint/RASPD_Fast_Protein-Ligand_Binding_Free_Energy_Prediction_Using_Simplified_Physicochemical_Features/12636704/2

A Simplified #Thermal #Proteome #Profiling Approach to Screen Protein #Targets of a #Ligand | #binding #fishing #screening #tpp #wetlab https://onlinelibrary.wiley.com/doi/10.1002/pmic.201900372

#Automated De Novo #Drug #Design: Are We Nearly There Yet? | #drugdesign #ligand https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201814681